Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 84 (18 Sep 2019)
Sequence version 1 (23 Mar 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Collagen, type XVIII, alpha 1, isoform CRA_d

Gene

COL18A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type XVIII, alpha 1, isoform CRA_dImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL18A1Imported
ORF Names:hCG_1647196Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501430248834 – 1336Sequence analysisAdd BLAST1303

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D3DSM4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 229LAM_G_DOMAINInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni230 – 1025DisorderedSequence analysisAdd BLAST796
Regioni1093 – 1138DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi301 – 325PolarSequence analysisAdd BLAST25
Compositional biasi349 – 376Pro-richSequence analysisAdd BLAST28
Compositional biasi384 – 398Pro-richSequence analysisAdd BLAST15
Compositional biasi446 – 460Pro-richSequence analysisAdd BLAST15
Compositional biasi488 – 502Pro-richSequence analysisAdd BLAST15
Compositional biasi523 – 547Pro-richSequence analysisAdd BLAST25
Compositional biasi589 – 607Pro-richSequence analysisAdd BLAST19
Compositional biasi838 – 854Pro-richSequence analysisAdd BLAST17
Compositional biasi905 – 922PolyampholyteSequence analysisAdd BLAST18
Compositional biasi937 – 951Pro-richSequence analysisAdd BLAST15
Compositional biasi960 – 1019Pro-richSequence analysisAdd BLAST60
Compositional biasi1098 – 1112PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

CollagenSAAS annotationImported, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546 Eukaryota
ENOG410XQ04 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231591

Database of Orthologous Groups

More...
OrthoDBi
1362001at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247 Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 5 hits
PF06482 Endostatin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3DSM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPRCPWPWP RRRRLLDVLA PLVLLLGVRA ASAEPERISE EVGLLQLLGD
60 70 80 90 100
PPPQQVTQTD DPDVGLAYVF GPDANSGQVA RYHFPSLFFR DFSLLFHIRP
110 120 130 140 150
ATEGPGVLFA ITDSAQAMVL LGVKLSGVQD GHQDISLLYT EPGAGQTHTA
160 170 180 190 200
ASFRLPAFVG QWTHLALSVA GGFVALYVDC EEFQRMPLAR SSRGLELEPG
210 220 230 240 250
AGLFVAQAGG ADPDKFQGVI AELKVRRDPQ VSPMHCLDEE GDDSDGASGD
260 270 280 290 300
SGSGLGDARE LLREETGAAL KPRLPAPPPV TTPPLAGGSS TEDSRSEEVE
310 320 330 340 350
EQTTVASLGA QTLPGSDSVS TWDGSVRTPG GRVKEGGLKG QKGEPGVPGP
360 370 380 390 400
PGRAGPPGSP CLPGPPGLPC PVSPLGPAGP ALQTVPGPQG PPGPPGRDGT
410 420 430 440 450
PGRDGEPGDP GEDGKPGDTG PQGFPGTPGD VGPKGDKGDP GVGERGPPGP
460 470 480 490 500
QGPPGPPGPS FRHDKLTFID MEGSGFGGDL EALRGPRGFP GPPGPPGVPG
510 520 530 540 550
LPGEPGRFGV NSSDVPGPAG LPGVPGREGP PGFPGLPGPP GPPGREGPPG
560 570 580 590 600
RTGQKGSLGE AGAPGHKGSK GAPGPAGARG ESGLAGAPGP AGPPGPPGPP
610 620 630 640 650
GPPGPGLPAG FDDMEGSGGP FWSTARSADG PQGPPGLPGL KGDPGVPGLP
660 670 680 690 700
GAKGEVGADG VPGFPGLPGR EGIAGPQGPK GDRGSRGEKG DPGKDGVGQP
710 720 730 740 750
GLPGPPGPPG PVVYVSEQDG SVLSVPGPEG RPGFAGFPGP AGPKGNLGSK
760 770 780 790 800
GERGSPGPKG EKGEPGSIFS PDGGALGPAQ KGAKGEPGFR GPPGPYGRPG
810 820 830 840 850
YKGEIGFPGR PGRPGMNGLK GEKGEPGDAS LGFGMRGMPG PPGPPGPPGP
860 870 880 890 900
PGTPVYDSNV FAESSRPGPP GLPGNQGPPG PKGAKGEVGP PGPPGQFPFD
910 920 930 940 950
FLQLEAEMKG EKGDRGDAGQ KGERGEPGGG GFFGSSLPGP PGPPGPRGYP
960 970 980 990 1000
GIPGPKGESI RGQPGPPGPQ GPPGIGYEGR QGPPGPPGPP GPPSFPGPHR
1010 1020 1030 1040 1050
QTISVPGPPG PPGPPGPPGT MGASSGVRLW ATRQAMLGQV HEVPEGWLIF
1060 1070 1080 1090 1100
VAEQEELYVR VQNGFRKVQL EARTPLPRGT DNEVAALQPP VVQLHDSNPY
1110 1120 1130 1140 1150
PRREHPHPTA RPWRADDILA SPPRLPEPQP YPGAPHHSSY VHLRPARPTS
1160 1170 1180 1190 1200
PPAHSHRDFQ PVLHLVALNS PLSGGMRGIR GADFQCFQQA RAVGLAGTFR
1210 1220 1230 1240 1250
AFLSSRLQDL YSIVRRADRA AVPIVNLKDE LLFPSWEALF SGSEGPLKPG
1260 1270 1280 1290 1300
ARIFSFDGKD VLRHPTWPQK SVWHGSDPNG RRLTESYCET WRTEAPSATG
1310 1320 1330
QASSLLGGRL LGQSAASCHH AYIVLCIENS FMTASK
Length:1,336
Mass (Da):135,510
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16B7FB340F2B3CB6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471079 Genomic DNA Translation: EAX09341.1
CH471079 Genomic DNA Translation: EAX09343.1

NCBI Reference Sequences

More...
RefSeqi
NP_569712.2, NM_130445.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80781

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471079 Genomic DNA Translation: EAX09341.1
CH471079 Genomic DNA Translation: EAX09343.1
RefSeqiNP_569712.2, NM_130445.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiD3DSM4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80781

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80781

Phylogenomic databases

eggNOGiKOG3546 Eukaryota
ENOG410XQ04 LUCA
HOGENOMiHOG000231591
OrthoDBi1362001at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL18A1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80781

Family and domain databases

CDDicd00247 Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01391 Collagen, 5 hits
PF06482 Endostatin, 1 hit
SMARTiView protein in SMART
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3DSM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3DSM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: September 18, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again