Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin beta

Gene

ITGB2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported, ReceptorImported
Biological processCell adhesionUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB2Imported
ORF Names:hCG_401305Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160255.16
HGNCiHGNC:6155 ITGB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei644 – 670HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501456973923 – 712Integrin betaSequence analysisAdd BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi134 ↔ 141UniRule annotation
Disulfide bondi189 ↔ 229UniRule annotation
Disulfide bondi363 ↔ 605UniRule annotation
Disulfide bondi388 ↔ 392UniRule annotation
Disulfide bondi410 ↔ 449UniRule annotation
Disulfide bondi415 ↔ 424UniRule annotation
Disulfide bondi426 ↔ 440UniRule annotation
Disulfide bondi455 ↔ 460UniRule annotation
Disulfide bondi457 ↔ 492UniRule annotation
Disulfide bondi462 ↔ 477UniRule annotation
Disulfide bondi479 ↔ 484UniRule annotation
Disulfide bondi500 ↔ 505UniRule annotation
Disulfide bondi502 ↔ 533UniRule annotation
Disulfide bondi507 ↔ 516UniRule annotation
Disulfide bondi539 ↔ 544UniRule annotation
Disulfide bondi541 ↔ 586UniRule annotation
Disulfide bondi546 ↔ 555UniRule annotation
Disulfide bondi558 ↔ 561UniRule annotation
Disulfide bondi565 ↔ 574UniRule annotation
Disulfide bondi571 ↔ 638UniRule annotation
Disulfide bondi590 ↔ 613UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000160255

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 74PSIInterPro annotationAdd BLAST51
Domaini32 – 390INBInterPro annotationAdd BLAST359
Domaini565 – 643Integrin_B_tailInterPro annotationAdd BLAST79
Domaini667 – 712Integrin_b_cytInterPro annotationAdd BLAST46

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119064
HOGENOMiHOG000252936
HOVERGENiHBG006190

Family and domain databases

Gene3Di1.20.5.630, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015439 Integrin_bsu-2
IPR014836 Integrin_bsu_cyt_dom
IPR037076 Integrin_bsu_cyt_dom_sf
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR032695 Integrin_dom_sf
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 2 hits
PTHR10082:SF15 PTHR10082:SF15, 2 hits
PfamiView protein in Pfam
PF08725 Integrin_b_cyt, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PIRSFiPIRSF002512 Integrin_B, 2 hits
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM01241 Integrin_b_cyt, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00243 INTEGRIN_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

D3DSM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN
60 70 80 90 100
FTGPGDPDSI RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP
110 120 130 140 150
QKVTLYLRPG FGSFVDKTVL PFVNTHPDKL RNPCPNKEKE CQPPFAFRHV
160 170 180 190 200
LKLTNNSNQF QTEVGKQLIS GNLDAPEGGL DAMMQVAACP EEIGWRNVTR
210 220 230 240 250
LLVFATDDGF HFAGDGKLGA ILTPNDGRCH LEDNLYKRSN EFDYPSVGQL
260 270 280 290 300
AHKLAENNIQ PIFAVTSRMV KTYEKLTEII PKSAVGELSE DSSNVVHLIK
310 320 330 340 350
NAYNKLSSRV FLDHNALPDT LKVTYDSFCS NGVTHRNQPR GDCDGVQINV
360 370 380 390 400
PITFQVKVTA TECIQEQSFV IRALGFTDIV TVQVLPQCEC RCRDQSRDRS
410 420 430 440 450
LCHGKGFLEC GICRCDTGYI GKNCECQTQG RSSQELEGSC RKDNNSIICS
460 470 480 490 500
GLGDCVCGQC LCHTSDVPGK LIYGQYCECD TINCERYNGQ VCGGPGRGLC
510 520 530 540 550
FCGKCRCHPG FEGSACQCER TTEGCLNPRR VECSGRGRCR CNVCECHSGY
560 570 580 590 600
QLPLCQECPG CPSPCGKYIS CAECLKFEKG PFGKNCSAAC PGLQLSNNPV
610 620 630 640 650
KGRTCKERDS EGCWVAYTLE QQDGMDRYLI YVDESRECVA GPNIAAIVGG
660 670 680 690 700
TVAGIVLIGI LLLVIWKALI HLSDLREYRR FEKEKLKSQW NNDNPLFKSA
710
TTTVMNPKFA ES
Length:712
Mass (Da):78,354
Last modified:March 23, 2010 - v1
Checksum:i9F9D372A27AE6C0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL773603 Genomic DNA No translation available.
AL844907 Genomic DNA No translation available.
AL844908 Genomic DNA No translation available.
KC877928 Genomic DNA No translation available.
CH471079 Genomic DNA Translation: EAX09383.1
CH471079 Genomic DNA Translation: EAX09384.1
UniGeneiHs.375957

Genome annotation databases

EnsembliENST00000397854; ENSP00000380952; ENSG00000160255
UCSCiuc010gpw.4 human

Similar proteinsi

Entry informationi

Entry nameiD3DSM0_HUMAN
AccessioniPrimary (citable) accession number: D3DSM0
Secondary accession number(s): A8MYE6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health