UniProtKB - D3DPZ6 (D3DPZ6_HUMAN)
Protein
Adenine DNA glycosylase
Gene
MUTYH
Organism
Homo sapiens (Human)
Status
Functioni
Adenine glycosylase active on G-A mispairs.UniRule annotation
Catalytic activityi
- Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.UniRule annotationARBA annotation EC:3.2.2.31
Cofactori
[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-UniRule
- DNA binding Source: InterPro
- hydrolase activity, acting on glycosyl bonds Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-UniRule
GO - Biological processi
- base-excision repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | GlycosidaseUniRule annotationARBA annotation, Hydrolase |
Biological process | DNA damage, DNA repairARBA annotation |
Ligand | 4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Adenine DNA glycosylaseUniRule annotationARBA annotation (EC:3.2.2.31UniRule annotationARBA annotation) |
Gene namesi | Name:MUTYHImported ORF Names:hCG_1780049Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 247 – 378 | Nudix hydrolaseInterPro annotationAdd BLAST | 132 |
Sequence similaritiesi
Family and domain databases
CDDi | cd03431, DNA_Glycosylase_C, 1 hit cd00056, ENDO3c, 1 hit |
Gene3Di | 1.10.1670.10, 1 hit |
InterProi | View protein in InterPro IPR011257, DNA_glycosylase IPR004036, Endonuclease-III-like_CS2 IPR003651, Endonuclease3_FeS-loop_motif IPR004035, Endouclease-III_FeS-bd_BS IPR003265, HhH-GPD_domain IPR000445, HhH_motif IPR023170, HTH_base_excis_C IPR029119, MutY_C IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00633, HHH, 1 hit PF00730, HhH-GPD, 1 hit PF14815, NUDIX_4, 1 hit |
SMARTi | View protein in SMART SM00478, ENDO3c, 1 hit SM00525, FES, 1 hit |
SUPFAMi | SSF48150, SSF48150, 1 hit SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS00764, ENDONUCLEASE_III_1, 1 hit PS01155, ENDONUCLEASE_III_2, 1 hit PS51462, NUDIX, 1 hit |
i Sequence
Sequence statusi: Complete.
D3DPZ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLDRRAYAV WVSEVMLQQT QVATVINYYT GWMQKWPTLQ DLASASLEEV
60 70 80 90 100
NQLWAGLGYY SRGRRLQEGA RKVVEELGGH MPRTAETLQQ LLPGVGRYTA
110 120 130 140 150
GAIASIAFGQ ATGVVDGNVA RVLCRVRAIG ADPSSTLVSQ QLWGLAQQLV
160 170 180 190 200
DPARPGDFNQ AAMELGATVC TPQRPLCSQC PVESLCRARQ RVEQEQLLAS
210 220 230 240 250
GSLSGSPDVE ECAPNTGQCH LCLPPSEPWD QTLGVVNFPR KASRKPPREE
260 270 280 290 300
SSATCVLEQP GALGAQILLV QRPNSGLLAG LWEFPSVTWE PSEQLQRKAL
310 320 330 340 350
LQELQRWAGP LPATHLRHLG EVVHTFSHIK LTYQVYGLAL EGQTPVTTVP
360 370 380 390 400
PGARWLTQEE FHTAAVSTAM KKVFRVYQGQ QPGTCMGSKR SQVSSPCSRK
410 420
KPRMGQQVLD NFFRSHISTD AHSLNSAAQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471059 Genomic DNA Translation: EAX06998.1 CH471059 Genomic DNA Translation: EAX07000.1 |
RefSeqi | NP_001280121.1, NM_001293192.1 NP_001280125.1, NM_001293196.1 XP_016856824.1, XM_017001335.1 |
Genome annotation databases
GeneIDi | 4595 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471059 Genomic DNA Translation: EAX06998.1 CH471059 Genomic DNA Translation: EAX07000.1 |
RefSeqi | NP_001280121.1, NM_001293192.1 NP_001280125.1, NM_001293196.1 XP_016856824.1, XM_017001335.1 |
3D structure databases
SMRi | D3DPZ6 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | D3DPZ6 |
Genome annotation databases
GeneIDi | 4595 |
Organism-specific databases
CTDi | 4595 |
Miscellaneous databases
BioGRID-ORCSi | 4595, 10 hits in 847 CRISPR screens |
GenomeRNAii | 4595 |
Family and domain databases
CDDi | cd03431, DNA_Glycosylase_C, 1 hit cd00056, ENDO3c, 1 hit |
Gene3Di | 1.10.1670.10, 1 hit |
InterProi | View protein in InterPro IPR011257, DNA_glycosylase IPR004036, Endonuclease-III-like_CS2 IPR003651, Endonuclease3_FeS-loop_motif IPR004035, Endouclease-III_FeS-bd_BS IPR003265, HhH-GPD_domain IPR000445, HhH_motif IPR023170, HTH_base_excis_C IPR029119, MutY_C IPR015797, NUDIX_hydrolase-like_dom_sf IPR000086, NUDIX_hydrolase_dom |
Pfami | View protein in Pfam PF00633, HHH, 1 hit PF00730, HhH-GPD, 1 hit PF14815, NUDIX_4, 1 hit |
SMARTi | View protein in SMART SM00478, ENDO3c, 1 hit SM00525, FES, 1 hit |
SUPFAMi | SSF48150, SSF48150, 1 hit SSF55811, SSF55811, 1 hit |
PROSITEi | View protein in PROSITE PS00764, ENDONUCLEASE_III_1, 1 hit PS01155, ENDONUCLEASE_III_2, 1 hit PS51462, NUDIX, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D3DPZ6_HUMAN | |
Accessioni | D3DPZ6Primary (citable) accession number: D3DPZ6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 23, 2010 |
Last sequence update: | March 23, 2010 | |
Last modified: | December 2, 2020 | |
This is version 67 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |