Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 55 (16 Oct 2019)
Sequence version 1 (23 Mar 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Polymerase (DNA directed), theta, isoform CRA_d

Gene

POLQ

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polymerase (DNA directed), theta, isoform CRA_dImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLQImported
ORF Names:hCG_2022564Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
D3DN91

PRoteomics IDEntifications database

More...
PRIDEi
D3DN91

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 234Helicase C-terminalInterPro annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni714 – 740DisorderedSequence analysisAdd BLAST27
Regioni1274 – 1302DisorderedSequence analysisAdd BLAST29
Regioni1457 – 1477DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1338 – 1368Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1274 – 1301PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1462 – 1477PolarSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0950 Eukaryota
COG0749 LUCA
COG1204 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR002298 DNA_polymerase_A
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10133 PTHR10133, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00476 DNA_pol_A, 1 hit
PF00271 Helicase_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00868 DNAPOLI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00490 HELICc, 1 hit
SM00482 POLAc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D3DN91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTMLLVYVM RRFVITIQYY FFVHQRNGVR SWQISLLESF IIYIIKLRVR
60 70 80 90 100
LVKPSECPPV ILEQKELLEV MDQLRRLPSG LDSVLQKTVP WGVAFHHAGL
110 120 130 140 150
TFEERDIIEG AFRQGLIRVL AATSTLSSGV NLPARRVIIR TPIFGGRPLD
160 170 180 190 200
ILTYKQMVGR AGRKGVDTVG ESILICKNSE KSKGIALLQG SLKPVRSCLQ
210 220 230 240 250
RREGEEVTGS MIRAILEIIV GGVASTSQDM HTYAACTFLA ASMKEGKQGI
260 270 280 290 300
QRNQESVQLG AIEACVMWLL ENEFIQSTEA SDGTEGKVYH PTHLGSATLS
310 320 330 340 350
SSLSPADTLD IFADLQRAMK GFVLENDLHI LYLVTPMFED WTTIDWYRFF
360 370 380 390 400
CLWEKLPTSM KRVAELVGVE EGFLARCVKG KVVARTERQH RQMAIHKRFF
410 420 430 440 450
TSLVLLDLIS EVPLREINQK YGCNRGQIQS LQQSAAVYAG MITVFSNRLG
460 470 480 490 500
WHNMELLLSQ FQKRLTFGIQ RELCDLVRVS LLNAQRARVL YASGFHTVAD
510 520 530 540 550
LARANIVEVE VILKNAVPFK SARKAVDEEE EAVEERRNMR TIWVTGRKGL
560 570 580 590 600
TEREAAALIV EEARMILQQD LVEMGVQWNP CALLHSSTCS LTHSESEVKE
610 620 630 640 650
HTFISQTKSS YKKLTSKNKS NTIFSDSYIK HSPNIVQDLN KSREHTSSFN
660 670 680 690 700
CNFQNGNQEH QTCSIFRARK RASLDINKEK PGASQNEGKT SDKKVVQTFS
710 720 730 740 750
QKTKKAPLNF NSEKMSRSFR SWKRRKHLKR SRDSSPLKDS GACRIHLQGQ
760 770 780 790 800
TLSNPSLCED PFTLDEKKTE FRNSGPFAKN VSLSGKEKDN KTSFPLQIKQ
810 820 830 840 850
NCSWNITLTN DNFVEHIVTG SQSKNVTCQA TSVVSEKGRG VAVEAEKINE
860 870 880 890 900
VLIQNGSKNQ NVYMKHHDIH PINQYLRKQS HEQTSTITKQ KNIIERQMPC
910 920 930 940 950
EAVSSYINRD SNVTINCERI KLNTEENKPS HFQALGDDIS RTVIPSEVLP
960 970 980 990 1000
SAGAFSKSEG QHENFLNISR LQEKTGTYTT NKTKNNHVSD LGLVLCDFED
1010 1020 1030 1040 1050
SFYLDTQSEK IIQQMATENA KLGAKDTNLA AGIMQKSLVQ QNSMNSFQKE
1060 1070 1080 1090 1100
CHIPFPAEQH PLGATKIDHL DLKTVGTMKQ SSDSHGVDIL TPESPIFHSP
1110 1120 1130 1140 1150
ILLEENGLFL KKNEVSVTDS QLNSFLQGYQ TQETVKPVIL LIPQKRTPTG
1160 1170 1180 1190 1200
VEGECLPVPE TSLNMSDSLL FDSFSDDYLV KEQLPDMQMK EPLPSEVTSN
1210 1220 1230 1240 1250
HFSDSLCLQE DLIKKSNVNE NQDTHQQLTC SNDESIIFSE MDSVQMVEAL
1260 1270 1280 1290 1300
DNVDIFPVQE KNHTVVSPRA LELSDPVLDE HHQGDQDGGD QDERAEKSKL
1310 1320 1330 1340 1350
TGTRQNHSFI WSGASFDLSP GLQRILDKVS SPLENEKLKS MTINFSSLNR
1360 1370 1380 1390 1400
KNTELNEEQE VISNLETKQV QGISFSSNNE VKSKIEMLEN NANHDETSSL
1410 1420 1430 1440 1450
LPRKESNIVD DNGLIPPTPI PTSASKLTFP GILETPVNPW KTNNVLQPGE
1460 1470 1480 1490 1500
SYLFGSPSDI KNHDLSPGSR NGFKDNSPIS DTSFSLQLSQ DGLQLTPASS
1510 1520 1530 1540 1550
SSESLSIIDV ASDQNLFQTF IKEWRCKKRF SISLACEKIR SLTSSKTATI
1560 1570 1580 1590 1600
GSRFKQASSP QEIPIRDDGF PIKGCDDTLV VGLAVCWGGR DAYYFSLQKE
1610 1620 1630 1640 1650
QKHSEISASL VPPSLDPSLT LKDRMWYLQS CLRKESDKEC SVVIYDFIQS
1660 1670 1680 1690 1700
YKILLLSCGI SLEQSYEDPK VACWLLDPDS QEPTLHSIVT SFLPHELPLL
1710 1720 1730 1740 1750
EGMETSQGIQ SLGLNAGSEH SGRYRASVES ILIFNSMNQL NSLLQKENLQ
1760 1770 1780 1790 1800
DVFRKVEMPS QYCLALLELN GIGFSTAECE SQKHIMQAKL DAIETQAYQL
1810 1820 1830 1840 1850
AGHSFSFTSS DDIAEVLFLE LKLPPNREMK NQGSKKTLGS TRRGIDNGRK
1860 1870 1880 1890 1900
LRLGRQFSTS KDVLNKLKAL HPLPGLILEW RRITNAITKV VFPLQREKCL
1910 1920 1930 1940 1950
NPFLGMERIY PVSQSHTATG RITFTEPNIQ NVPRDFEIKM PTLVGESPPS
1960 1970 1980 1990 2000
QAVGKGLLPM GRGKYKKGFS VNPRCQAQME ERAADRGMPF SISMRHAFVP
2010 2020 2030 2040 2050
FPGGSILAAD YSQLELRILA HLSHDRRLIQ VLNTGADVFR SIAAEWKMIE
2060 2070 2080 2090 2100
PESVGDDLRQ QAKQICYGII YGMGAKSLGE QMGIKENDAA CYIDSFKSRY
2110 2120 2130 2140 2150
TGINQFMTET VKNCKRDGFV QTILGRRRYL PGIKDNNPYR KAHAERQAIN
2160 2170 2180 2190 2200
TIVQGSAADI VKIATVNIQK QLETFHSTFK SHGHREGMLQ SDRTGLSRKR
2210 2220 2230 2240 2250
KLQGMFCPIR GGFFILQLHD ELLYEVAEED VVQVAQIVKN EMESAVKLSV
2260 2270
KLKVKVKIGA SWGELKDFDV
Length:2,270
Mass (Da):254,934
Last modified:March 23, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01E2DFECFE99BE4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471052 Genomic DNA Translation: EAW79513.1
CH471052 Genomic DNA Translation: EAW79514.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471052 Genomic DNA Translation: EAW79513.1
CH471052 Genomic DNA Translation: EAW79514.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiD3DN91
PRIDEiD3DN91

Phylogenomic databases

eggNOGiKOG0950 Eukaryota
COG0749 LUCA
COG1204 LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
POLQ human

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR002298 DNA_polymerase_A
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF00476 DNA_pol_A, 1 hit
PF00271 Helicase_C, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00490 HELICc, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD3DN91_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D3DN91
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: October 16, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again