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Protein

Malate dehydrogenase

Gene

mdh

Organism
Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35NADUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei103SubstrateUniRule annotation1
Binding sitei110NADUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Binding sitei166SubstrateUniRule annotation1
Active sitei190Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi133 – 135NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHTHE608538:G1GOC-765-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
Ordered Locus Names:HTH_0756Imported
OrganismiHydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)Imported
Taxonomic identifieri608538 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeHydrogenobacter
Proteomesi
  • UP000002574 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi608538.HTH_0756

Structurei

3D structure databases

ProteinModelPortaliD3DHB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 157Ldh_1_NInterPro annotationAdd BLAST151
Domaini161 – 326Ldh_1_CInterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit

Sequencei

Sequence statusi: Complete.

D3DHB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMRKVVSVI GAGNVGEHVA SLLALRGLVD VRMFDIPRKD GEKVIEPVKG
60 70 80 90 100
KALDIRQMLA AIDIDAKVEG YTVSPEGNGY EALEGSDIIV ITAGFPRRPG
110 120 130 140 150
MSREDLLEKN LSILSVICEK IKQYAKEAII IVVTNPVDLM TYAVYKMLGF
160 170 180 190 200
SKRKVMGMAG VLDSARFKTF ISQEVKVSPK DIHAYVIGGH GDEMVPLISI
210 220 230 240 250
SNVGGIPLKD MLPKEKLSEL IKRTQFGGGE IVDLMGTSAY YAPAASIVEM
260 270 280 290 300
VEAIVTDNKR ILPCSVYLEG EEGKYYEAED VCVGVPVKLG NCGVEEIINI
310 320 330
PMLPEEREMW RRSVSSVRKN LKVVEEMLHA RSVL
Length:334
Mass (Da):36,700
Last modified:March 23, 2010 - v1
Checksum:iEEBE0AFB32D2F129
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP011112 Genomic DNA Translation: BAI69216.1
RefSeqiWP_012963397.1, NC_017161.1

Genome annotation databases

EnsemblBacteriaiBAI69216; BAI69216; HTH_0756
KEGGihte:Hydth_0756
hth:HTH_0756
PATRICifig|608538.5.peg.766

Similar proteinsi

Entry informationi

Entry nameiD3DHB4_HYDTT
AccessioniPrimary (citable) accession number: D3DHB4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 23, 2010
Last sequence update: March 23, 2010
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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