UniProtKB - D2X2I0 (D2X2I0_ANOCA)
Protein
Submitted name:
Neuroligin 4
Gene
nlgn4
Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Functioni
GO - Molecular functioni
- neurexin family protein binding Source: GO_Central
- signaling receptor activity Source: GO_Central
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- modulation of chemical synaptic transmission Source: GO_Central
- neuron cell-cell adhesion Source: GO_Central
- postsynaptic membrane assembly Source: GO_Central
- presynaptic membrane assembly Source: GO_Central
- synaptic vesicle endocytosis Source: GO_Central
Keywordsi
Biological process | Cell adhesionARBA annotation |
Protein family/group databases
ESTHERi | anoca-nlgn4, Neuroligin |
MEROPSi | S09.989 |
Names & Taxonomyi
Protein namesi | Submitted name: Neuroligin 4Imported |
Gene namesi | Name:nlgn4Imported Synonyms:nlgn4xImported |
Organismi | Anolis carolinensis (Green anole) (American chameleon)Imported |
Taxonomic identifieri | 28377 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Iguania › Dactyloidae › Anolis |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cell surface Source: GO_Central
- presynapse Source: GOC
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 693 – 716 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, SynapseARBA annotationExpressioni
Gene expression databases
Bgeei | ENSACAG00000004520, Expressed in testis and 6 other tissues |
Interactioni
GO - Molecular functioni
- neurexin family protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004479 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 45 – 610 | COesteraseInterPro annotationAdd BLAST | 566 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 160 – 180 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 638 – 680 | DisorderedSequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 655 – 669 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the type-B carboxylesterase/lipase family.ARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000156607 |
HOGENOMi | CLU_006586_5_1_1 |
OrthoDBi | 754103at2759 |
TreeFami | TF326187 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR000460, Nlgn IPR030025, NLGN4 |
PANTHERi | PTHR43903:SF5, PTHR43903:SF5, 2 hits |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
PRINTSi | PR01090, NEUROLIGIN |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit |
i Sequence
Sequence statusi: Complete.
D2X2I0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRPMGLLWL PLIFTPVCVM LNSNFLFWIT ALAIRFTLID GQAQYPVVTT
60 70 80 90 100
NYGKIRGVRT PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGI
110 120 130 140 150
RNATQFAAVC PQYLDERSLL NDMLPVWFTA NLDTVMTYVQ DQNEDCLYLN
160 170 180 190 200
VYVPTEDGAN TKKSADDITS NDRGEDEDIH DQNSKKPVMV YIHGGSYMEG
210 220 230 240 250
TGNIVDGSIL ASYGNVIVVT INYRLGVLGF LSTGDQAAKG NYGLLDQIQA
260 270 280 290 300
LRWIEENIGS FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS
310 320 330 340 350
GTALSSWAVN YQPAKYTAIL AEKVGCNTLD TTDLVECFRN KNYKELIQQT
360 370 380 390 400
ITPATYHIAF GPVIDGDVIP DDPQILMEQG EFLNYDIMLG VNQGEGLKFV
410 420 430 440 450
DGIVDNEEGV SPNDFDFSVS NFVDNLYGYP EGKDTLRETI KFMYTDWADK
460 470 480 490 500
ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM
510 520 530 540 550
KPSWADSAHG DEVPYVFGIP MIGPTELFNC NFSKNDVMLS AVVMTYWTNF
560 570 580 590 600
AKTGDPNQPV PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD
610 620 630 640 650
HYRATKVAFW LELVPHLHNL NEIFQYVSTT TKVPPPDLTS FPYVTRRSPG
660 670 680 690 700
KFTTKRPLMT PSNNPKHSKD TQKTSPEDTS VLIENKRDYS TELSVTIAVG
710 720 730 740 750
ASLLFLNILA FAALYYKKDK RRHETHRRPS PQRNTTNDIA HIQNEEIMSL
760 770 780 790 800
QMKQLEHDHE CESLQAHDTL RLTCPPDYTL TLRRSPDDIP LMTPNTITMI
810 820 830
PNTLTGMQPL HTFNTFSGGQ NSTNLPHGHS TTRV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ489211 mRNA Translation: ADB12638.1 |
RefSeqi | NP_001278319.1, NM_001291390.1 XP_008105338.1, XM_008107131.2 XP_008105339.1, XM_008107132.2 XP_016847409.1, XM_016991920.1 |
Genome annotation databases
Ensembli | ENSACAT00000004582; ENSACAP00000004479; ENSACAG00000004520 |
GeneIDi | 100337529 |
KEGGi | acs:100337529 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ489211 mRNA Translation: ADB12638.1 |
RefSeqi | NP_001278319.1, NM_001291390.1 XP_008105338.1, XM_008107131.2 XP_008105339.1, XM_008107132.2 XP_016847409.1, XM_016991920.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 28377.ENSACAP00000004479 |
Protein family/group databases
ESTHERi | anoca-nlgn4, Neuroligin |
MEROPSi | S09.989 |
Genome annotation databases
Ensembli | ENSACAT00000004582; ENSACAP00000004479; ENSACAG00000004520 |
GeneIDi | 100337529 |
KEGGi | acs:100337529 |
Organism-specific databases
CTDi | 57502 |
Phylogenomic databases
eggNOGi | KOG1516, Eukaryota |
GeneTreei | ENSGT00940000156607 |
HOGENOMi | CLU_006586_5_1_1 |
OrthoDBi | 754103at2759 |
TreeFami | TF326187 |
Gene expression databases
Bgeei | ENSACAG00000004520, Expressed in testis and 6 other tissues |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019819, Carboxylesterase_B_CS IPR000460, Nlgn IPR030025, NLGN4 |
PANTHERi | PTHR43903:SF5, PTHR43903:SF5, 2 hits |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
PRINTSi | PR01090, NEUROLIGIN |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00941, CARBOXYLESTERASE_B_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D2X2I0_ANOCA | |
Accessioni | D2X2I0Primary (citable) accession number: D2X2I0 Secondary accession number(s): G1KCY5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 2, 2010 |
Last sequence update: | March 2, 2010 | |
Last modified: | December 2, 2020 | |
This is version 70 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |