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UniProtKB - D2WKD9 (SDR1_AEDAE)
Protein
Farnesol dehydrogenase
Gene
SDR-1
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Functioni
Mediates oxidation of farnesol into farnesal, a precursor of juvenile hormone in the corpora allata (CA), the glands that synthesize juvenile hormone. Able to oxidize C(10) to C(15) isoprenoid and aliphatic alcohols.
1 PublicationCatalytic activityi
- EC:1.1.1.2161 Publication
Kineticsi
- KM=91 µM for (E,E) farnesol1 Publication
- KM=97 µM for (Z,Z) farnesol1 Publication
- KM=184 µM for 2-decanol1 Publication
- KM=208 µM for geraniol (E)1 Publication
- KM=109 µM for nerol (Z)1 Publication
- KM=133 µM for citronellol1 Publication
- KM=195 µM for octanol1 Publication
pH dependencei
Optimum pH is 10-11.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 64 | NADBy similarity | 1 | |
Binding sitei | 145 | SubstrateBy similarity | 1 | |
Active sitei | 160 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 | |
Binding sitei | 164 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 11 – 40 | NADBy similarityAdd BLAST | 30 |
GO - Molecular functioni
- farnesol dehydrogenase activity Source: UniProtKB
GO - Biological processi
- juvenile hormone biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD, NADP |
Enzyme and pathway databases
BRENDAi | 1.1.1.216, 149 |
Names & Taxonomyi
Protein namesi | Recommended name: Farnesol dehydrogenaseCurated (EC:1.1.1.2161 Publication)Alternative name(s): NADP(+)-dependent farnesol dehydrogenase 11 Publication Short name: AaSDR-11 Publication |
Gene namesi | Name:SDR-11 Publication Synonyms:FOHSDR-1Imported ORF Names:AaeL_AAEL017302Imported |
Organismi | Aedes aegypti (Yellowfever mosquito) (Culex aegypti)Imported |
Taxonomic identifieri | 7159 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | VectorBase:AAEL017302 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000432713 | 1 – 245 | Farnesol dehydrogenaseAdd BLAST | 245 |
Expressioni
Tissue specificityi
Highly expressed level in the midgut and brain in adult females, and at lower level in the abdominal and thoracic ganglia. High levels are detected in corpora allata (CA), Malpighian tubules and fat body.1 Publication
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 7159.AAEL017302-PA |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | KOG1205, Eukaryota |
HOGENOMi | CLU_010194_2_10_1 |
OrthoDBi | 1190834at2759 |
PhylomeDBi | D2WKD9 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
D2WKD9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRWAGKVAV VTGASSGIGA AITTDLAKAG MVVVGLARRV ERVEALKANL
60 70 80 90 100
PESAKPRLHA VKCDVSKEED ITQVFKWVEK KFGGVDVLVN NAGILRQTDL
110 120 130 140 150
LGTDNGQMLR EVLDTNVMGL VLCSQKAYQS MKKRSVDGHI VHINSVVGHK
160 170 180 190 200
VFDFPQSNIY PASKHAVTAI TETMRNELRN AGSRIKVTSI SPGVVRTEIL
210 220 230 240
PESIIEGGHA LLESEDISEA VLYVLGTPPR VQVHELTIKP VGEKF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | K → E in ADB03639 (PubMed:19940247).Curated | 1 | |
Sequence conflicti | 210 | A → S in ADB03639 (PubMed:19940247).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ344797 mRNA Translation: ADB03639.1 CH477512 Genomic DNA Translation: EJY57755.1 |
RefSeqi | XP_011492954.1, XM_011494652.1 |
Genome annotation databases
GeneIDi | 23687722 |
KEGGi | aag:23687722 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ344797 mRNA Translation: ADB03639.1 CH477512 Genomic DNA Translation: EJY57755.1 |
RefSeqi | XP_011492954.1, XM_011494652.1 |
3D structure databases
AlphaFoldDBi | D2WKD9 |
SMRi | D2WKD9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7159.AAEL017302-PA |
Genome annotation databases
GeneIDi | 23687722 |
KEGGi | aag:23687722 |
Organism-specific databases
VEuPathDBi | VectorBase:AAEL017302 |
Phylogenomic databases
eggNOGi | KOG1205, Eukaryota |
HOGENOMi | CLU_010194_2_10_1 |
OrthoDBi | 1190834at2759 |
PhylomeDBi | D2WKD9 |
Enzyme and pathway databases
BRENDAi | 1.1.1.216, 149 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SDR1_AEDAE | |
Accessioni | D2WKD9Primary (citable) accession number: D2WKD9 Secondary accession number(s): J9HZ43 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 2015 |
Last sequence update: | April 1, 2015 | |
Last modified: | May 25, 2022 | |
This is version 51 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families