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Entry version 43 (10 Apr 2019)
Sequence version 1 (02 Mar 2010)
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Protein
Submitted name:

Predicted protein

Gene

NAEGRDRAFT_69406

Organism
Naegleria gruberi (Amoeba)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:NAEGRDRAFT_69406Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNaegleria gruberi (Amoeba)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5762 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaHeteroloboseaSchizopyrenidaVahlkampfiidaeNaegleria
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006671 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2 – 36PPRPROSITE-ProRule annotationAdd BLAST35
Repeati105 – 139PPRPROSITE-ProRule annotationAdd BLAST35
Repeati140 – 170PPRPROSITE-ProRule annotationAdd BLAST31
Repeati176 – 206PPRPROSITE-ProRule annotationAdd BLAST31
Repeati210 – 244PPRPROSITE-ProRule annotationAdd BLAST35
Repeati245 – 275PPRPROSITE-ProRule annotationAdd BLAST31
Repeati298 – 332PPRPROSITE-ProRule annotationAdd BLAST35
Repeati333 – 363PPRPROSITE-ProRule annotationAdd BLAST31
Repeati368 – 398PPRPROSITE-ProRule annotationAdd BLAST31
Repeati402 – 436PPRPROSITE-ProRule annotationAdd BLAST35
Repeati437 – 471PPRPROSITE-ProRule annotationAdd BLAST35
Repeati493 – 527PPRPROSITE-ProRule annotationAdd BLAST35
Repeati528 – 558PPRPROSITE-ProRule annotationAdd BLAST31
Repeati563 – 597PPRPROSITE-ProRule annotationAdd BLAST35
Repeati598 – 632PPRPROSITE-ProRule annotationAdd BLAST35
Repeati633 – 663PPRPROSITE-ProRule annotationAdd BLAST31
Repeati668 – 702PPRPROSITE-ProRule annotationAdd BLAST35
Repeati703 – 737PPRPROSITE-ProRule annotationAdd BLAST35
Repeati738 – 768PPRPROSITE-ProRule annotationAdd BLAST31
Repeati773 – 807PPRPROSITE-ProRule annotationAdd BLAST35
Repeati853 – 887PPRPROSITE-ProRule annotationAdd BLAST35
Repeati888 – 922PPRPROSITE-ProRule annotationAdd BLAST35
Repeati925 – 959PPRPROSITE-ProRule annotationAdd BLAST35
Repeati960 – 990PPRPROSITE-ProRule annotationAdd BLAST31
Repeati996 – 1027PPRPROSITE-ProRule annotationAdd BLAST32
Repeati1059 – 1093PPRPROSITE-ProRule annotationAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1099 – 1221DYW_deaminaseInterPro annotationAdd BLAST123
Repeati1105 – 1140PPRPROSITE-ProRule annotationAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4197 Eukaryota
ENOG410Z7Z7 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D2VKI6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032867 DYW_dom
IPR002885 Pentatricopeptide_repeat
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14432 DYW_deaminase, 1 hit
PF01535 PPR, 1 hit
PF13041 PPR_2, 8 hits
PF13812 PPR_3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00756 PPR, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51375 PPR, 27 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D2VKI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNVFLYTHFI NNCIWNDDLE RALAIVLNMK GKDIEPNYAI YIPLLKAATV
60 70 80 90 100
KKNIQVGMTL YQLVKKSNLA SPQLSTTIIS FALKLRKPEL VIEEIELVKQ
110 120 130 140 150
QKWMTIITWN SLIQAYIQEN NIKKAIDVIH EMKDNGICPD SATFNILITA
160 170 180 190 200
CANTKLFAEG KLIHKITTNT LKDNCSVELL TSIINFYTKC GHPEIAINEC
210 220 230 240 250
EKMKSKGLMN VVSFTCLVEA YIQINEIQKA IDTVTEMKQF KVTPNATTFS
260 270 280 290 300
ILLTACAKLK LYKEGILIHK IANNTLRDNS SLKLLTSIIN FYTKYIKKYY
310 320 330 340 350
GWNCLIQAYI QNKEVRQAIE IITEMQDYGV EPNSTTFNIL LTACADSKLF
360 370 380 390 400
EEGKAIHKLA TGTLKDYSSE LLASIVNFYT KCGHPETAIK ECEQLKSKGL
410 420 430 440 450
MNNIVWNCLI QAYIQNKEVR QAIEVITEMQ DYGIEPNSTT FNILLKACAD
460 470 480 490 500
SKLFEEGKLL HQASGQVLNN PTIELNNTID QFEKMKTKGF EANVITWTCL
510 520 530 540 550
IQAHVQNKEV RQAIEVITEM QDYGIEPNST TFNILLTACA DSKLFEEGKL
560 570 580 590 600
IHEQAIENVK DCSTELLTSI INFYTKCGHP ETAIKECEKL KLKGLMNNVA
610 620 630 640 650
VWNCLIQAHI QNNEVQKAIE IITEMQQFGL NPDSTTYTII LKACTDSNLF
660 670 680 690 700
EEGKFIHEQA IENVKDCSTE LLTSIISFYT KCGHPEVSIG ECEKLQSKGL
710 720 730 740 750
MNNIAVWNCL IQAHIQNNEV QKSIKIITEM QDYGIEPNST TFNILLTACA
760 770 780 790 800
DSKLFEEGKA IHKLATGTLK DYSAELLASI VNFYTKCGHP EVSIEECEQL
810 820 830 840 850
KSKGLMNNVA IWNCLIQAHI QNTTNTQNPS TIEYGLNKAM VVFNEMKEHI
860 870 880 890 900
EPDKITYLIL LAGCGEYVAR KMGLDIIDEL KLKGMDVHEE IVSVMIYFYS
910 920 930 940 950
RIAYQSTAQQ LFEKLVEESA QKRLSIITYN NMLSCYAQHG KGTQAMNLFN
960 970 980 990 1000
EMVDKNVEMN EQTFTIMLNT FSHCGMIDEA NQLYGEMKTK YNHNPSVIVD
1010 1020 1030 1040 1050
CVMVDVFARS GRFHEAEKII NERMNYSLWS ALLAGCRKFN NVELGEKVFK
1060 1070 1080 1090 1100
ILLSIDEKKA PPYILLSNIY TYYGLNEKAD NIRQLMIENG IKKIPGIVYQ
1110 1120 1130 1140 1150
EEDGKSYQFV SGSKKYERFK EIEKMREEIY RKIIQAGFEP DTRWVTNSKL
1160 1170 1180 1190 1200
LTEEEKLDSL CRHAEKTATA HAFVLNPKRK SIILAANLRV CNDCHTATEF
1210 1220 1230
ISKVMDVEII IRDANRYHHF KDGKCSCDGY W
Length:1,231
Mass (Da):140,134
Last modified:March 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i717DEE28E9DC9096
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GG738878 Genomic DNA Translation: EFC42601.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EFC42601; EFC42601; NAEGRDRAFT_69406

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG738878 Genomic DNA Translation: EFC42601.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEFC42601; EFC42601; NAEGRDRAFT_69406

Phylogenomic databases

eggNOGiKOG4197 Eukaryota
ENOG410Z7Z7 LUCA
InParanoidiD2VKI6

Family and domain databases

Gene3Di1.25.40.10, 9 hits
InterProiView protein in InterPro
IPR032867 DYW_dom
IPR002885 Pentatricopeptide_repeat
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF14432 DYW_deaminase, 1 hit
PF01535 PPR, 1 hit
PF13041 PPR_2, 8 hits
PF13812 PPR_3, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
TIGRFAMsiTIGR00756 PPR, 9 hits
PROSITEiView protein in PROSITE
PS51375 PPR, 27 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2VKI6_NAEGR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2VKI6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: April 10, 2019
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
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