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UniProtKB - D2VJG4 (D2VJG4_NAEGR)

Entry version 44 (12 Aug 2020)
Sequence version 1 (02 Mar 2010)
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Protein
Submitted name:

Predicted protein

Gene

NAEGRDRAFT_50049

Organism
Naegleria gruberi (Amoeba)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:NAEGRDRAFT_50049Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNaegleria gruberi (Amoeba)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5762 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Discoba › Heterolobosea › Tetramitia › Eutetramitia › Vahlkampfiidae › Naegleria
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006671 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		5762.XP_002675779.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		D2VJG4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini623 – 788CKKInterPro annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 36DisorderedSequence analysisAdd BLAST36
Regioni49 – 92DisorderedSequence analysisAdd BLAST44
Regioni129 – 364DisorderedSequence analysisAdd BLAST236
Regioni507 – 545DisorderedSequence analysisAdd BLAST39
Regioni700 – 723DisorderedSequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 92PolarSequence analysisAdd BLAST30
Compositional biasi140 – 222AcidicSequence analysisAdd BLAST83
Compositional biasi228 – 273PolarSequence analysisAdd BLAST46
Compositional biasi274 – 291AcidicSequence analysisAdd BLAST18
Compositional biasi300 – 330PolarSequence analysisAdd BLAST31
Compositional biasi334 – 357AcidicSequence analysisAdd BLAST24
Compositional biasi518 – 545PolyampholyteSequence analysisAdd BLAST28
Compositional biasi700 – 717PolarSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3654, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D2VJG4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032940, CAMSAP
IPR014797, CKK_domain
IPR011033, PRC_barrel-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR21595, PTHR21595, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08683, CAMSAP_CKK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01051, CAMSAP_CKK, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50346, SSF50346, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51508, CKK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D2VJG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRIEKQNYI IEEEDDEDSY KDLSSEGEDE HAPEDLLASV TTVVKVDTIS 
        60         70         80         90        100
KSPAKGGGSY AQMYKNSKKS NENLQQQTKN NSSSKGQSVN PRICLVNDSL 
       110        120        130        140        150
VSLSAIKNTN MNSFPQRYQA DLTCSYSISE STLPEHQTQQ EVDEEEEEEE 
       160        170        180        190        200
MECSDYENEQ QDEKQEDEEE NKEEYNEETE EDHQEYNEES QDEDQEEETD 
       210        220        230        240        250
EFKESEEVQD EEEEEENQEE ETDFQVREVT RSTNNLNARN SSSSSIARSS 
       260        270        280        290        300
IRTSIAEDMR YSTQHQNSIA YGSEDDSETD ELAEEKEHID EEIDEAVLPP 
       310        320        330        340        350
SNSMTKSMLK QSFSEKVISE ESSLANTIKT EIEGTDDEEG DGYKDLEELE 
       360        370        380        390        400
TEVQDDAEDE LQTNHVHRSV EKHQDNLPTV VTTRNEEMKH QSSDMKENIL 
       410        420        430        440        450
QSISLFKQYK ANQVSQSVVG LDHSSKKLKT PTDQPLRVSK VLEIPKPNIN 
       460        470        480        490        500
LNESISENDM DKIKKQNHLL RMQLLEQQRM IEEGKIVLQE RIEQEIERAK 
       510        520        530        540        550
SEALKDFISS KKQQTPTPTE QKPEKKTVRD MKKSESPEKS VETIRVKESP 
       560        570        580        590        600
RATIATTKPK KKEVIEILPD EFENTADMKK QMEMRNKKFL EVRKQKIEKI 
       610        620        630        640        650
EETKKKEKPQ PISTEAKTAE NGMILKNMKQ PNKTNKLLIK NALIHLTLAG 
       660        670        680        690        700
EVNKKEREDV FEAMKEYEDT NQMIILVREV NVPAFRALYV VVTDGLNANV 
       710        720        730        740        750
GSSTSTTDSN RTDNSSRSES PNIEKRSDQI LVKKIIGKGP KFLTEDVVDV 
       760        770        780 
FCRYDSGGKK LSKLSSRTFG VTTDVVVLKS AAIKKIKR
Length:788
Mass (Da):90,193
Last modified:March 2, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2032FDF32A61A425
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
GG738876 Genomic DNA Translation: EFC43035.1

Genome annotation databases

Ensembl protists genome annotation project

More...EnsemblProtistsi		EFC43035; EFC43035; NAEGRDRAFT_50049

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG738876 Genomic DNA Translation: EFC43035.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6QUYelectron microscopy3.80W621-788[»]
6QVEelectron microscopy3.70W621-788[»]
SMRiD2VJG4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi5762.XP_002675779.1

Genome annotation databases

EnsemblProtistsiEFC43035; EFC43035; NAEGRDRAFT_50049

Phylogenomic databases

eggNOGiKOG3654, Eukaryota
InParanoidiD2VJG4

Family and domain databases

InterProiView protein in InterPro
IPR032940, CAMSAP
IPR014797, CKK_domain
IPR011033, PRC_barrel-like_sf
PANTHERiPTHR21595, PTHR21595, 1 hit
PfamiView protein in Pfam
PF08683, CAMSAP_CKK, 1 hit
SMARTiView protein in SMART
SM01051, CAMSAP_CKK, 1 hit
SUPFAMiSSF50346, SSF50346, 1 hit
PROSITEiView protein in PROSITE
PS51508, CKK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2VJG4_NAEGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2VJG4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: August 12, 2020
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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