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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43NADUniRule annotation1
Binding sitei70NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi168Iron; shared with adjacent protomerUniRule annotation1
Binding sitei168NAD; shared with adjacent protomerUniRule annotation1
Metal bindingi183IronUniRule annotation1
Binding sitei258NAD; via amide nitrogenUniRule annotation1
Binding sitei268GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 63NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

BioCyciHTUR543526:GH7B-1490-MONOMER
UniPathwayi
UPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
Ordered Locus Names:Htur_1462Imported
OrganismiHaloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (Halococcus turkmenicus)Imported
Taxonomic identifieri543526 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaNatrialbalesNatrialbaceaeHaloterrigena
Proteomesi
  • UP000001903 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi543526.Htur_1462

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OMAiMTEFTDI
OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

D2RQL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEFEQFSQV GEADVTRAIG QEWTEEFMDF SDSDVIIVGG GPSGLTAAKE
60 70 80 90 100
LSERGVKTMV VEKNNYLGGG FWLGGFLMNK VTVRDPAQQI LDELDVSHKQ
110 120 130 140 150
SEDSEGLYIA NGPEACSGLI KAACDAGAKM QNMTEFTDIV IREDHKVSGI
160 170 180 190 200
VMNWTPVHAL PREITCVDPI AVEADLVIDA TGHDAMAVKK LDERGVLDAP
210 220 230 240 250
GIADAKESAT GMDQTDDDTY GAPGHDSPGH DSMWVGKSED AVVEHTGLVH
260 270 280 290 300
DGLIATGMAT ATTYGLPRMG PTFGAMLVSG KRAAQVALDE LEVDAEPVDI
310
TSRAATPADD
Length:310
Mass (Da):32,914
Last modified:March 2, 2010 - v1
Checksum:i5225ADABA7F0EDBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA Translation: ADB60348.1
RefSeqiWP_012942653.1, NC_013743.1

Genome annotation databases

EnsemblBacteriaiADB60348; ADB60348; Htur_1462
GeneIDi8742053
KEGGihtu:Htur_1462

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001860 Genomic DNA Translation: ADB60348.1
RefSeqiWP_012942653.1, NC_013743.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi543526.Htur_1462

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADB60348; ADB60348; Htur_1462
GeneIDi8742053
KEGGihtu:Htur_1462

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OMAiMTEFTDI
OrthoDBiPOG093Z09PU

Enzyme and pathway databases

UniPathwayi
UPA00060

BioCyciHTUR543526:GH7B-1490-MONOMER

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD2RQL7_HALTV
AccessioniPrimary (citable) accession number: D2RQL7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 2, 2010
Last sequence update: March 2, 2010
Last modified: October 10, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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