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UniProtKB - D2K762 (SQS3_PANGI)
Protein
Squalene synthase 3
Gene
SS3
Organism
Panax ginseng (Korean ginseng)
Status
Functioni
Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:29378087).
Catalyzes the biosynthesis of squalene (By similarity).
1 PublicationBy similarityCatalytic activityi
- EC:2.5.1.21By similarityThis reaction proceeds in the forward1 Publication direction.
- EC:2.5.1.21By similarityThis reaction proceeds in the forward1 Publication direction.
Cofactori
: lanosterol biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.By similarity This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.
GO - Molecular functioni
- farnesyl-diphosphate farnesyltransferase activity Source: UniProtKB-EC
- squalene synthase activity Source: UniProtKB-EC
GO - Biological processi
- isoprenoid biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Isoprene biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00767;UER00751 |
Names & Taxonomyi
Protein namesi | Recommended name: Squalene synthase 32 Publications (EC:2.5.1.21By similarity)Short name: PgSS32 Publications Short name: SQS 3Curated Alternative name(s): FPP:FPP farnesyltransferase SS3Curated Farnesyl-diphosphate farnesyltransferase SS3Curated |
Gene namesi | Name:SS31 Publication |
Organismi | Panax ginseng (Korean ginseng) |
Taxonomic identifieri | 4054 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › campanulids › Apiales › Araliaceae › Panax |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 281 – 301 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 392 – 412 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000446954 | 1 – 415 | Squalene synthase 3Add BLAST | 415 |
Family & Domainsi
Sequence similaritiesi
Belongs to the phytoene/squalene synthase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd00683, Trans_IPPS_HH, 1 hit |
Gene3Di | 1.10.600.10, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR002060, Squ/phyt_synthse IPR006449, Squal_synth-like IPR019845, Squalene/phytoene_synthase_CS IPR044844, Trans_IPPS_euk-type IPR033904, Trans_IPPS_HH |
PANTHERi | PTHR11626, PTHR11626, 1 hit |
Pfami | View protein in Pfam PF00494, SQS_PSY, 1 hit |
SFLDi | SFLDG01018, Squalene/Phytoene_Synthase_Lik, 1 hit |
SUPFAMi | SSF48576, SSF48576, 1 hit |
TIGRFAMsi | TIGR01559, squal_synth, 1 hit |
PROSITEi | View protein in PROSITE PS01044, SQUALEN_PHYTOEN_SYN_1, 1 hit PS01045, SQUALEN_PHYTOEN_SYN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
D2K762-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSLGAILKH PDDFYPLLKL KIAARHAEKQ IPSEPHWAFC YSMLHKVSRS
60 70 80 90 100
FGLVIQQLGP QLRDAVCIFY LVLRALDTVE DDTSISTEVK VPIVMAFHCH
110 120 130 140 150
IYDNDWHFSC GTKEYKVLMD EFHHVSNAFL DLGSSYKEAI EDITMRMGAG
160 170 180 190 200
MAKFICKEVE TIDDYDEYCH YVAGLVGLGL SKLFHASGAE DLATDSLSNS
210 220 230 240 250
MGLFLQKTNI IRDYLEDINE IPKSRMFWPR QIWSKYVDKL EDLKYEENSG
260 270 280 290 300
KAVQCLNDMV TNALLHVEDC LKYMSDLRDP AIFRFCAIPQ IMAIGTLALC
310 320 330 340 350
YNNIQVFRGV VKMRRGLTAK VIDRTNTMSD VYGTFFDFSC MLKSKVDNND
360 370 380 390 400
PNATKTLSRL EAIQKICKNS GALTTKRKSY IIENESGYNS TLIIILFIIL
410
AILYAYLSSN LPNSL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU183406 mRNA Translation: ACZ71037.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GU183406 mRNA Translation: ACZ71037.1 |
3D structure databases
SMRi | D2K762 |
ModBasei | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00767;UER00751 |
Family and domain databases
CDDi | cd00683, Trans_IPPS_HH, 1 hit |
Gene3Di | 1.10.600.10, 1 hit |
InterProi | View protein in InterPro IPR008949, Isoprenoid_synthase_dom_sf IPR002060, Squ/phyt_synthse IPR006449, Squal_synth-like IPR019845, Squalene/phytoene_synthase_CS IPR044844, Trans_IPPS_euk-type IPR033904, Trans_IPPS_HH |
PANTHERi | PTHR11626, PTHR11626, 1 hit |
Pfami | View protein in Pfam PF00494, SQS_PSY, 1 hit |
SFLDi | SFLDG01018, Squalene/Phytoene_Synthase_Lik, 1 hit |
SUPFAMi | SSF48576, SSF48576, 1 hit |
TIGRFAMsi | TIGR01559, squal_synth, 1 hit |
PROSITEi | View protein in PROSITE PS01044, SQUALEN_PHYTOEN_SYN_1, 1 hit PS01045, SQUALEN_PHYTOEN_SYN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SQS3_PANGI | |
Accessioni | D2K762Primary (citable) accession number: D2K762 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 8, 2019 |
Last sequence update: | February 9, 2010 | |
Last modified: | September 29, 2021 | |
This is version 26 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families