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Entry version 45 (11 Dec 2019)
Sequence version 1 (09 Feb 2010)
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Protein

ANK_REP_REGION domain-containing protein

Gene

PANDA_011068

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ANK_REP_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PANDA_011068Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini524 – 631ANK_REP_REGIONInterPro annotationAdd BLAST108
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati524 – 556ANKPROSITE-ProRule annotationAdd BLAST33
Repeati557 – 589ANKPROSITE-ProRule annotationAdd BLAST33
Repeati593 – 625ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni455 – 507DisorderedSequence analysisAdd BLAST53
Regioni684 – 772DisorderedSequence analysisAdd BLAST89
Regioni826 – 926DisorderedSequence analysisAdd BLAST101

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi462 – 488AcidicSequence analysisAdd BLAST27
Compositional biasi489 – 503PolyampholyteSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0504 Eukaryota
KOG4308 Eukaryota
COG0666 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113022

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits
1.25.40.20, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF13516 LRR_6, 2 hits
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits
SM00367 LRR_CC, 2 hits
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF48452 SSF48452, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

D2HIM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NMERELRQLS KAKAKAQRSG QLRDEAALCH QLGELLASHG RYAEALREHQ
60 70 80 90 100
HELQLLESVD DPLGCAVAHR KIGERLAELE DYSAALKHQH RYLELAHSLS
110 120 130 140 150
NHTEVQRAWA TIGRTYLDIY DHCQSQDTLL QAQTAFEKSL AIVDEKLQGT
160 170 180 190 200
LAKRELSEMR TRLYLNLGLT FESLRQMAPC NDYFRKSIFL AEQNHLYEDL
210 220 230 240 250
FRARYNLGAI HWRRGQHSQA MRCLEGAREC ARVLRKELME SECCMLISQI
260 270 280 290 300
LQDLGDFLAA KRALKKAYRL GIQKPLQKAA VCRALKYVLA VVRLQQQLQE
310 320 330 340 350
SEGSDPQGAM GICEQLGDLF SKAGDFPKAA EAYQKQLHFA ELLGRPGPEL
360 370 380 390 400
AIIHVSLATT LGDMKDYRRA VSHYEQELRL RGGDALEEAK TWLNIALSRE
410 420 430 440 450
EAGDAYELLA PCFQKALSCA QQAQRPQLQR QVLQHLHTVQ LRLQPQEAPV
460 470 480 490 500
TAATLQELSV PRDQEDDDEE EKEGDGDTPE ASDVELSESE GDAEGRSQQL
510 520 530 540 550
EEDEELQGCL GQQRVNKWNR RNDVGETLLH RACIEGRLGR VQDLVRQGHP
560 570 580 590 600
LNPRDYCGWT PLHEACNYGH LDIVRFLLDH GAVVDDPGGP GCEGITPLHD
610 620 630 640 650
ALHCGHFEVA ELLIERGASV TLRTMKGHSP LETLQQWVKL YGKDLDSETR
660 670 680 690 700
EKAGSMESLL RAASSGQGKW TPHSSLAPHI LPRNHLFDPE ISPPSSPCPG
710 720 730 740 750
PPETSQARAG VSPGQAVPAA ARPRRTRHNL ASSSSSEGED NPGPPRPVQK
760 770 780 790 800
RPRHYVPAQQ ARTGVPGSTS SREAVAVSAT RAAVRGVGGA QICCPGPGLR
810 820 830 840 850
WGPGEPTPPR AALIPEEACL AGDWLEDDSP LTHSHQGGYL PHPQGSGDGT
860 870 880 890 900
RPGGLGSGGS KSPGRLRARA RQSRLPRLRS WNALSRAGGD SSAAELPRSP
910 920 930 940 950
DMSRASGPSG DSPAAGQPLG PSLPPPIRVR VRVQDSLFLI PVPHSRETHS
960 970 980 990 1000
VAWLAEQAAQ RYCQACGLLP RLVLRKEGAL LAPQDPIPDV LQSNEEVLAE
1010 1020 1030 1040 1050
VTSWDLPPLT DRYRRACQSL EQEEDQEVLQ AVDRQGSGPS FSACSLALHQ
1060 1070 1080 1090 1100
TQLTPLLRAL KLHTALRELH LAGNRLGDGC AAELLAALGT MPSLVLLDLS
1110 1120 1130 1140 1150
SNHLGPEGLR QLATGLQGQT ALQNLQELDL SMNPLGDGCG RALAFILQAC
1160 1170 1180 1190 1200
PSLSTLHLQA CGFGPSFFLS HQAALGSAFQ DAKHLQTLSL SYNILGTAAL
1210 1220 1230 1240 1250
AHALQNLPAH NLQRLELSSV AASKSDSGLV EPVVRYLTKE GCVLAHLSLS
1260 1270 1280 1290 1300
ANHLGDKAVG DLSRCLPCCP SLISLDLSAN PEISCVGLEE LLSALQMRPQ
1310 1320 1330 1340 1350
DLSFLGLSGC AVQGPLGLGL WREITTRVHE LQLCSRRLSP EDRAALRQLL
1360 1370
PGQPGPGACS LDRGPKLFFR RL
Length:1,372
Mass (Da):149,744
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBD3C997F24D1287E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1372Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL192891 Genomic DNA Translation: EFB17008.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL192891 Genomic DNA Translation: EFB17008.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
KOG4308 Eukaryota
COG0666 LUCA
HOGENOMiHOG000113022

Family and domain databases

Gene3Di1.25.40.10, 2 hits
1.25.40.20, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF13516 LRR_6, 2 hits
PF13176 TPR_7, 1 hit
PF13181 TPR_8, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SM00367 LRR_CC, 2 hits
SM00028 TPR, 7 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2HIM4_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2HIM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: December 11, 2019
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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