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Entry version 57 (26 Feb 2020)
Sequence version 1 (09 Feb 2010)
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Protein
Submitted name:

Uncharacterized protein

Gene

PANDA_009359

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PANDA_009359Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1332 – 1353HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 141CSInterPro annotationAdd BLAST90
Domaini321 – 423CSInterPro annotationAdd BLAST103
Domaini538 – 1255USPInterPro annotationAdd BLAST718
Domaini832 – 874MYND-typeInterPro annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 52DisorderedSequence analysisAdd BLAST52
Regioni154 – 234DisorderedSequence analysisAdd BLAST81
Regioni274 – 299DisorderedSequence analysisAdd BLAST26
Regioni422 – 481DisorderedSequence analysisAdd BLAST60
Regioni970 – 992DisorderedSequence analysisAdd BLAST23
Regioni1259 – 1280DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 52PolyampholyteSequence analysisAdd BLAST36
Compositional biasi172 – 186PolyampholyteSequence analysisAdd BLAST15
Compositional biasi210 – 224PolyampholyteSequence analysisAdd BLAST15
Compositional biasi461 – 479PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1259 – 1274PolyampholyteSequence analysisAdd BLAST16

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1870 Eukaryota
COG5560 LUCA

Database of Orthologous Groups

More...
OrthoDBi
1283205at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04969 CS, 1 hit
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764 SSF49764, 2 hits
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51203 CS, 2 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

D2HEV9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGASATGP RRGPPGLEEA TSKKKQKDRA NQESKDGDPR RGSASSREEQ
60 70 80 90 100
AKEELLLDWR QSADEVIVKL RVGAGPLRLE EVDAAFTDTD CVVRLPGGRQ
110 120 130 140 150
WGGVFYAEIE SSCTKVQARK GGLLQLALPK KVPLLTWPSL LKPLGTQEAV
160 170 180 190 200
PGLRCQENGQ EPSPIALEPG PEPRRAKQEA RNQKRAQGRG EVGAGAGPGA
210 220 230 240 250
QAGPSAKRAV HLRRGPEGEG SRDGPGPRGD APPFLAETAT QAEAEEQLRV
260 270 280 290 300
PPLNPQTCLL GSEENLALLA GEKTVSARSD PVSPAMARSR DPEKGDRSKE
310 320 330 340 350
EMAVAADAIT LVAEPESMVN LAFVKNDSYE KGPDSVVVHV YVKEIRRDTS
360 370 380 390 400
RVLFREQDFT LIFQTRDGNF LRLHPGCGPH TIFRWQVKLR NLIEPEQCTF
410 420 430 440 450
CFTASRIDIC LRKRQSQRWG GLEAPAPRGA VGGAKVAVPT GPTPLDSTPP
460 470 480 490 500
GGTPHPLTGQ EEARAVEKEK PKARSEDTGL DGVAARTPME HVTPKPEPHL
510 520 530 540 550
ASPKPTCMVP PMPHSPVSGD SVEEEEEEEK KVCLPGFTGL VNLGNTCFMN
560 570 580 590 600
SVIQSLSNTR ELRDFFHDRS FEAEINYNNP LGTGGRLAIG FAVLLRALWK
610 620 630 640 650
GTHHAFQPSK LKAIVASKAS QFTGYAQHDA QEFMAFLLDG LHEDLNRIQN
660 670 680 690 700
KPYTETVDSD GRPDEVVAEE AWQRHKMRND SFIVDLFQGQ YKSKLVCPVC
710 720 730 740 750
AKVSITFDPF LYLPVPLPQK QKVLPVFYFA REPHSKPIKF LVSISKENSS
760 770 780 790 800
ASEVLESLSQ SVHVKSENLR LAEVIKNRFH RVFLPSHSLD TVSPSDTLLC
810 820 830 840 850
FELLPPELAK ERVVVLEVQQ RPQVPSVPIS KCAACQRKQQ SEDEKLKRCT
860 870 880 890 900
RCYRVGYCNQ LCQKTHWPDH KGLCRPENIG YPFLVSVPAS RLTYARLAQL
910 920 930 940 950
LEGYARYSVS VFQPPFQPGR MALESQGPGC TTLLSTSSLE AGDSERDLIQ
960 970 980 990 1000
PPELQLVTPV AEGDAGVPRA WAAPDRGPVP STSGVSSEVL AGGPVEVGSL
1010 1020 1030 1040 1050
PASERVSRPE AAVPGYQHPS EAMNAHTPQF FIYKIDASNR EQRLEDKGDT
1060 1070 1080 1090 1100
PLELGEDCSL ALVWRNNERL QEFVLVASKE LECAEDPGSA GEAARAGHFT
1110 1120 1130 1140 1150
LDQCLNLFTR PEVLAPEEAW YCPQCKQHRE ASKQLLLWRL PNVLIVQLKR
1160 1170 1180 1190 1200
FSFRSFIWRD KINDLVEFPV RNLDLSKFCI GQKEEQLPSY DLYAVINHYG
1210 1220 1230 1240 1250
GMIGGHYTAC ARLPNDRSSQ RSDVGWRLFD DSTVTTVDES QVVTRYAYVL
1260 1270 1280 1290 1300
FYRRRNSPVE RPPRAGHSEH HPDLGPAAEA AASQASRIWQ ELEAEEEPVP
1310 1320 1330 1340 1350
EGPVPLGPWG PQDWVGPPPR GPTTPDEGCL RYFVLGTVAA LVALVLNVFY

PLVSQSRWR
Length:1,359
Mass (Da):149,943
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D47492A113A79E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1359Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL192765 Genomic DNA Translation: EFB13940.1

NCBI Reference Sequences

More...
RefSeqi
XP_019656640.1, XM_019801081.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109488328

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL192765 Genomic DNA Translation: EFB13940.1
RefSeqiXP_019656640.1, XM_019801081.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi109488328

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10869

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
OrthoDBi1283205at2759

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR002893 Znf_MYND
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF00443 UCH, 1 hit
PF01753 zf-MYND, 1 hit
SUPFAMiSSF49764 SSF49764, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 2 hits
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS01360 ZF_MYND_1, 1 hit
PS50865 ZF_MYND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2HEV9_AILME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2HEV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: February 26, 2020
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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