UniProtKB - D2HER1 (D2HER1_AILME)
Protein
Peptidyl-prolyl cis-trans isomerase
Gene
PANDA_009301
Organism
Ailuropoda melanoleuca (Giant panda)
Status
Functioni
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation
Catalytic activityi
- [protein]-peptidylproline (ω=180) = [protein]-peptidylproline (ω=0)UniRule annotationARBA annotationEC:5.2.1.8UniRule annotationARBA annotation
GO - Molecular functioni
- peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-UniRule
- RNA binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | Isomerase, RNA-bindingPROSITE-ProRule annotation, RotamaseUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)Short name: PPIaseUniRule annotation |
Gene namesi | ORF Names:PANDA_009301Imported |
Organismi | Ailuropoda melanoleuca (Giant panda)Imported |
Taxonomic identifieri | 9646 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Ursidae › Ailuropoda |
Subcellular locationi
Keywords - Cellular componenti
NucleusUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 138 | PPIase cyclophilin-typeInterPro annotationAdd BLAST | 138 | |
Domaini | 217 – 295 | RRMInterPro annotationAdd BLAST | 79 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 144 – 165 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 347 – 384 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 400 – 469 | DisorderedSequence analysisAdd BLAST | 70 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_018791_3_2_1 |
Family and domain databases
CDDi | cd01921, cyclophilin_RRM, 1 hit |
Gene3Di | 2.40.100.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR035542, CRIP IPR029000, Cyclophilin-like_dom_sf IPR002130, Cyclophilin-type_PPIase_dom IPR035538, Cyclophilin_PPIL4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR45843, PTHR45843, 1 hit |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50072, CSA_PPIASE_2, 1 hit PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Fragment.
D2HER1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ACLNFLKLCK IKYYNYCLIH NVQRDFIIQT GDPTGTGRGG ESVFGQLYGD
60 70 80 90 100
QASFFEAEKV PRIKHKKKGT VSMVNNGSDQ HGSQFLITTG DNLDYLDGVH
110 120 130 140 150
TVFGEVTEGM DIIKKINETF VDKDFVPYQD IRINHTVILD DPFDDPPDLL
160 170 180 190 200
IPDRSPEPTR EQLDSGRIGA DEEIDDFKGR SAEEVEEIKA EKEAKTQAIL
210 220 230 240 250
LEMVGDLPDA DIKPPENVLF VCKLNPVTTD EDLEIIFSRF GPIRSCEVIR
260 270 280 290 300
DWKTGESLCY AFIEFEKEED CEKAFFKMDN VLIDDRRIHV DFSQSVAKVK
310 320 330 340 350
WKGKGGKYTK SDFKEYEKEQ DKPSNLVLKD KVKPKQDAKY DLVLDEQAED
360 370 380 390 400
AKSSHSHTSK KHKKKTRHCS EEKEDEDYMP IRNTNQDIYR EMGFGHYEEE
410 420 430 440 450
ESCWEKQKSE KRDRPQNRSR SRSRERDGHY SNSHKSKYQT DPYERERSKK
460
RDRSRSPKKS KDKEKSKYR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 469 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GL192764 Genomic DNA Translation: EFB29794.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GL192764 Genomic DNA Translation: EFB29794.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Phylogenomic databases
HOGENOMi | CLU_018791_3_2_1 |
Family and domain databases
CDDi | cd01921, cyclophilin_RRM, 1 hit |
Gene3Di | 2.40.100.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR035542, CRIP IPR029000, Cyclophilin-like_dom_sf IPR002130, Cyclophilin-type_PPIase_dom IPR035538, Cyclophilin_PPIL4 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR45843, PTHR45843, 1 hit |
Pfami | View protein in Pfam PF00160, Pro_isomerase, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00153, CSAPPISMRASE |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF50891, SSF50891, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50072, CSA_PPIASE_2, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | D2HER1_AILME | |
Accessioni | D2HER1Primary (citable) accession number: D2HER1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 9, 2010 |
Last sequence update: | February 9, 2010 | |
Last modified: | October 7, 2020 | |
This is version 57 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |