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Entry version 39 (31 Jul 2019)
Sequence version 1 (09 Feb 2010)
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Protein

RabBD domain-containing protein

Gene

PANDA_005664

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RabBD domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PANDA_005664Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 63RabBDInterPro annotationAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni93 – 115DisorderedSequence analysisAdd BLAST23
Regioni348 – 379DisorderedSequence analysisAdd BLAST32
Regioni841 – 902DisorderedSequence analysisAdd BLAST62
Regioni914 – 942DisorderedSequence analysisAdd BLAST29
Regioni1000 – 1106DisorderedSequence analysisAdd BLAST107
Regioni1170 – 1189DisorderedSequence analysisAdd BLAST20
Regioni1207 – 1227DisorderedSequence analysisAdd BLAST21
Regioni1311 – 1449DisorderedSequence analysisAdd BLAST139
Regioni1531 – 1606DisorderedSequence analysisAdd BLAST76
Regioni1644 – 1777DisorderedSequence analysisAdd BLAST134
Regioni1790 – 1811DisorderedSequence analysisAdd BLAST22
Regioni1945 – 2002DisorderedSequence analysisAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili14 – 45Sequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi94 – 115PolarSequence analysisAdd BLAST22
Compositional biasi348 – 376PolarSequence analysisAdd BLAST29
Compositional biasi863 – 877PolarSequence analysisAdd BLAST15
Compositional biasi1023 – 1051PolarSequence analysisAdd BLAST29
Compositional biasi1070 – 1097PolarSequence analysisAdd BLAST28
Compositional biasi1171 – 1186PolarSequence analysisAdd BLAST16
Compositional biasi1333 – 1347PolarSequence analysisAdd BLAST15
Compositional biasi1389 – 1404PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1405 – 1449PolarSequence analysisAdd BLAST45
Compositional biasi1544 – 1573PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1589 – 1603PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1663 – 1682PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1687 – 1720PolarSequence analysisAdd BLAST34
Compositional biasi1721 – 1737PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1945 – 1973PolarSequence analysisAdd BLAST29
Compositional biasi1977 – 2002AcidicSequence analysisAdd BLAST26

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEGS Eukaryota
ENOG4111DX8 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112418

KEGG Orthology (KO)

More...
KOi
K22236

Database of Orthologous Groups

More...
OrthoDBi
59101at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039916 EXPH5
IPR010911 Rab_BD
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR21469 PTHR21469, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50916 RABBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

D2H6P4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKVPQGFDF SFLNDEEARK ILQVLERNEE LQRAEKDRIS KLQKTKRDIR
60 70 80 90 100
WLQGVTGEWF EEIQRKKFCN ETDVSQMLKQ PLTYRLRKGM AENDSMELQT
110 120 130 140 150
SRSKNTPNQK SLTSISSRLS FRSSFASLFS FRKSRKETSK LQSLGQKGYD
160 170 180 190 200
SHAGPPVSVR QTITQAKIHS SPLENPPVES AFVPRPTGMR EGSGMSPWDA
210 220 230 240 250
SLLENEYFQV LDDLDNKLAQ EQCPSSVKTT TLLNYGSRTQ FSHFYSRGNT
260 270 280 290 300
HGNTGRHKNH YNETSNMSIY DILRPGAPRE GFKTFSPRTK TIYDMYRTRE
310 320 330 340 350
PRLLKDYMQK NTFGSTSLCF DSRQRSASPA TSYFTTRSLH FPTITQNKSG
360 370 380 390 400
FLSPRHQQSP KRTPLSSIIW NRSDASGDRQ SQEEFLRAPS PMDIDANDQY
410 420 430 440 450
AYPRCFQENR RYGFYRSQSV YQGAHFNAPM DNAMSPDPFE NSENMPFYPQ
460 470 480 490 500
ENPFARSFSS NTFGRNREQR FRQSPFWDQQ EEGSFWSDFH QSRHPFPPSD
510 520 530 540 550
RDFETISMEA NSALAARGHG VPSQHWGLFS SSYRTDMFRD QEEPHPWQFD
560 570 580 590 600
SQTSTLESME VPQGNGSQSA HFNIPNVCPM MGPSYHIKSH RSVCQEGSPP
610 620 630 640 650
AEVHMNQDAY PFGIAHTLAA SFQTSFPQIP DDGGNPQSSI FQNPTVTVQK
660 670 680 690 700
IKPASLPIKT YTEVTVTKRN SVDSPPLTES PPIVLASEVS HEKDLNESIL
710 720 730 740 750
EEDKQLNKMD QTNMPSEEPQ PDAQTVISNP FPDLRNPLSH DLAKSKGFAL
760 770 780 790 800
NASTTVSSKR TPGVIARKDI SKIHLSHRDK SNELKKDRNY TENRNVGSAT
810 820 830 840 850
ALPFIQESRI SFPSPSPGCH QEVRISHDDS LSIIRNHHWS SEQAGNQNAQ
860 870 880 890 900
SPEKPAVLDA EEEQCSTTHS TNYSESAAGP KIPCDSSDLS SGIPPDSSPL
910 920 930 940 950
DKSSLEALVF PSKTVFSRKS PSGKDPPLGE GEQKDNNSKC QNDQFALSPS
960 970 980 990 1000
EIRKSNDNCV VVHNEGVDAV KCHSRPPFRD GKGKGKIRRC ISCFEKLSKT
1010 1020 1030 1040 1050
ESGSAPTSHD SNLRERNRSN SKRPEIPTTY CNSPRKSASF LISNRKPESK
1060 1070 1080 1090 1100
IAPSSFRNEP LPFQIRNNVE DPMGTYTSNK LSSSSSEAES RCSKAASDSV
1110 1120 1130 1140 1150
SEVPEATKRM TNMKNIGSAS VRKGPLPFLI KRAVSCPLGA PDASAGTDER
1160 1170 1180 1190 1200
EKCLLSSTDA SALTRKPWGT VMSPLENNSP VSDGSLNRKP PQKEYFQECT
1210 1220 1230 1240 1250
EKDGKIASPR TGLFSNEDPL PFSSDVSRKE SGKTLHKFKT TSMFSVSGDE
1260 1270 1280 1290 1300
DNVKCLEVVS IYYTLPRKYS KKFCDILEKY TQQIDSLTES TKVETEMFPN
1310 1320 1330 1340 1350
AFEKGRLNYS MQEQSGTPAS EGQKMLVSSA PEDSCGLSHT TEDTTAFPDC
1360 1370 1380 1390 1400
RPSEPTVQEM ASSEAGVSFH KGELETREIS PDNFTKTPLG DSRSRKERGK
1410 1420 1430 1440 1450
KWQSEILHTS SQLSGKKVTG EKSRNCQQPI KSGNSGPPNL PSPLEENVGN
1460 1470 1480 1490 1500
SQTVRSSEEC AGNLVMTATG TAECLQKDTT GKAMVASASG LQPRQVRGEI
1510 1520 1530 1540 1550
GTDVQEETSK ALSDSESQVF ALTPALHNLQ LDGGTCSGEP DLDSSQSEPR
1560 1570 1580 1590 1600
ELPQRSQEAS RTENGKAEDK MQKLAWDQAS LPEGSNKYKT SVDDPEKGKN
1610 1620 1630 1640 1650
RSSVKHRLAA MSKVSRKFSA KDLSPRRHVA TIFPQSGNRC GFGSLSLGTP
1660 1670 1680 1690 1700
ECDPVSPEPT PKSIESRNEH RLSSDVMDVE KYENSPRVSV IPNSEVSTHL
1710 1720 1730 1740 1750
SNQKPNSISQ LHQSESKSIA ESSPKYERSK DVAAAQTLER DSEALAQPTF
1760 1770 1780 1790 1800
PSLGEADFSE HQRRPNPPFP LEPAEKSRVS IPLATYRQQQ SASSLEWEPE
1810 1820 1830 1840 1850
PHPYRSNSLK SISVHGDLVR KSHPPKVRER HFSESTSIVN ALSQPTLGNE
1860 1870 1880 1890 1900
FSSNSRYGRR FRSFSELSSC DANENWALCR SRTKMGPRSA TSISRPIDYG
1910 1920 1930 1940 1950
IFGKEQQLAF LETVKRSLTQ GRLWKPSFLK NPGFLKDDVI YTPNPTELSS
1960 1970 1980 1990 2000
SNSPSSQKPE DDLSPSTPLN IYEENPLDSD CDTDTTTDDE YYLDENDKES

EL
Length:2,002
Mass (Da):223,241
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44FDB199FD511B56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei2002Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL192532 Genomic DNA Translation: EFB21444.1

NCBI Reference Sequences

More...
RefSeqi
XP_019653241.1, XM_019797682.1
XP_019653242.1, XM_019797683.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100472667

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aml:100472667

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL192532 Genomic DNA Translation: EFB21444.1
RefSeqiXP_019653241.1, XM_019797682.1
XP_019653242.1, XM_019797683.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi100472667
KEGGiaml:100472667

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23086

Phylogenomic databases

eggNOGiENOG410IEGS Eukaryota
ENOG4111DX8 LUCA
HOGENOMiHOG000112418
KOiK22236
OrthoDBi59101at2759

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039916 EXPH5
IPR010911 Rab_BD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR21469 PTHR21469, 1 hit
PROSITEiView protein in PROSITE
PS50916 RABBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2H6P4_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2H6P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: July 31, 2019
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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