Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 72 (08 May 2019)
Sequence version 1 (09 Feb 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Protein tyrosine phosphatase, receptor type G

Gene

PTPRG

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei998Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein tyrosine phosphatase, receptor type GImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTPRGImported
ORF Names:PANDA_003486Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei675 – 700HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9646.ENSAMEP00000016231

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 259Alpha-carbonic anhydraseInterPro annotationAdd BLAST259
Domaini287 – 386Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini786 – 1057Tyrosine-protein phosphataseInterPro annotationAdd BLAST272
Domaini974 – 1048TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75
Domaini1088 – 1348Tyrosine-protein phosphataseInterPro annotationAdd BLAST261
Domaini1265 – 1339TYR_PHOSPHATASE_2InterPro annotationAdd BLAST75

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0382 Eukaryota
KOG0789 Eukaryota
COG3338 LUCA
COG5599 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155048

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060222

Identification of Orthologs from Complete Genome Data

More...
OMAi
PMTLDKN

TreeFam database of animal gene trees

More...
TreeFami
TF351978

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03122 alpha_CARP_receptor_like, 1 hit
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041887 alpha_CARP_receptor-type
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

D2H1R0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
TGAYGPEHWV TSSVSCGGRH QSPIDILDQH ARVGEEYQEL QLDGFDNESS
60 70 80 90 100
NKTWMKNTGK TVAILLKDDY FVSGAGLPGR FKAEKVEFHW GHSNGSAGSE
110 120 130 140 150
HSINGRRFPV EMQIFFYNPD DFDSFQTAIS ENRIIGAMAI FFQVSPRDNS
160 170 180 190 200
ALDPIIHGLK GVVHHEKETF LDPFVLRDLL PASLGSYYRY TGSLTTPPCS
210 220 230 240 250
EIVEWIVFRR PVPISYHQLE AFYSIFTTEQ QDHVKSVEYL RNNFRPQQGL
260 270 280 290 300
NGRVVSKSAV RDAWNHDMTD FLENPLGTEA SKVCSSPPIH MKVQPLNQTA
310 320 330 340 350
LQVSWSQPET IYHPPIMNYM ISYSWTKNED EKEKTFTKDS DKDLKATISH
360 370 380 390 400
VSPDSLYLFR VQAVCRNDMR SDFSQTMLFQ ANTTRIFQGT RIVKTGVPTA
410 420 430 440 450
SPASSADMAP ISSGSSTWTS SGIPFSFVSM ATGMGPSSSG SQATVASVVT
460 470 480 490 500
STLLAGLGFS GGGIPSFPST VWPTRLPTAA SASKQAVRPV LATTEALASP
510 520 530 540 550
GPDSDSAPTK DSEGAEEGEK DEKSESEDGE REHEDEGEKD SEKKKSGVTH
560 570 580 590 600
AAQEPRQDEP TPTPSSPNRT AEEGGHQTLP GPGQDHTAVP TDQPDDTRDA
610 620 630 640 650
RPGLDSGSVT STQVPPTVTE ERFEGSDPRR PQMPSKKPMS RGDRFSEDSK
660 670 680 690 700
FITVNPAEKN TSGMISRPSP GRMEWIIPLI VVSALTFVCL ILLIAVLVYW
710 720 730 740 750
RGCNKIKSKG FPRRFREVPS SGERGEKGSR KCFQTAHFYV EDSSSPRVVP
760 770 780 790 800
NESIPIIPIP DDMEAIPVKQ FVKHIGELYS NNQHGFSEDF EEVQRCTADM
810 820 830 840 850
NITAEHSNHP DNKHKNRYIN ILAYDHSRVK LRPLPGKDSK HSDYINANYV
860 870 880 890 900
DGYNKAKAYI ATQGPLKSTF EDFWRMIWEQ NTGIIIMITN LVEKGRRKCD
910 920 930 940 950
QYWPTENSEE YGNIIVTLKS TKVHACYTVR RFSVRNTKVK KGQKGNPKGR
960 970 980 990 1000
QNERVVIQYH YTQWPDMGVP EYALPVLTFV RRSSAARTPE MGPVLVHCSA
1010 1020 1030 1040 1050
GVGRTGTYIV IDSMLQQIKD KSTVNVLGFL KHIRTQRNYL VQTEEQYIFI
1060 1070 1080 1090 1100
HDALLEAILG KETEVSSNQL HSYVNSILIP GVGGKTRLEK QFKLVTQCNA
1110 1120 1130 1140 1150
KYVECFSAQK ECNKEKNRNS SVVPSERARV GLAPLPGMKG TDYINASYIM
1160 1170 1180 1190 1200
GYYRSNEFII TQHPLPHTTK DFWRMIWDHN AQIIVMLPDN QSLAEDEFVY
1210 1220 1230 1240 1250
WPSREESMNC EAFTVTLISK DRLCLSNEEQ IIIHDFILEA TQDDYVLEVR
1260 1270 1280 1290 1300
HFQCPKWPNP DAPISSTFEL INVIKEEALT RDGPTIVHDE YGAVSAGMLC
1310 1320 1330 1340 1350
ALTTLSQQLE NENAVDVFQV AKMINLMRPG VFTDIEQYQF VYKAMLSLVS
1360 1370 1380
TKENGNGPMT VDKNGAVLIA DESDPAESME SLV
Length:1,383
Mass (Da):154,645
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3FCA53A7BFC0BE44
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1MA60G1MA60_AILME
Protein tyrosine phosphatase, recep...
PTPRG
1,252Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G1MA62G1MA62_AILME
Protein tyrosine phosphatase, recep...
PTPRG
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G1MA65G1MA65_AILME
Protein tyrosine phosphatase, recep...
PTPRG
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1383Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ACTA01145369 Genomic DNA No translation available.
ACTA01153368 Genomic DNA No translation available.
ACTA01161367 Genomic DNA No translation available.
GL192432 Genomic DNA Translation: EFB25913.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMET00000016905; ENSAMEP00000016231; ENSAMEG00000015376

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01145369 Genomic DNA No translation available.
ACTA01153368 Genomic DNA No translation available.
ACTA01161367 Genomic DNA No translation available.
GL192432 Genomic DNA Translation: EFB25913.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000016231

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSAMET00000016905; ENSAMEP00000016231; ENSAMEG00000015376

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
KOG0789 Eukaryota
COG3338 LUCA
COG5599 LUCA
GeneTreeiENSGT00940000155048
HOGENOMiHOG000060222
OMAiPMTLDKN
TreeFamiTF351978

Family and domain databases

CDDicd03122 alpha_CARP_receptor_like, 1 hit
cd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR041887 alpha_CARP_receptor-type
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2H1R0_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2H1R0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 8, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again