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Entry version 32 (26 Feb 2020)
Sequence version 1 (09 Feb 2010)
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Protein

ENT domain-containing protein

Gene

PANDA_003315

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ENT domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PANDA_003315Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 78ENTInterPro annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 157DisorderedSequence analysisAdd BLAST31
Regioni170 – 194DisorderedSequence analysisAdd BLAST25
Regioni380 – 424DisorderedSequence analysisAdd BLAST45
Regioni677 – 715DisorderedSequence analysisAdd BLAST39
Regioni1186 – 1211DisorderedSequence analysisAdd BLAST26
Regioni1267 – 1301DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi380 – 417PolarSequence analysisAdd BLAST38
Compositional biasi1286 – 1301PolarSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4675 Eukaryota
ENOG410YF3T LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1240.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033482 EMSY
IPR005491 ENT_dom
IPR036142 ENT_dom-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR16500 PTHR16500, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03735 ENT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01191 ENT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158639 SSF158639, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51138 ENT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

D2H1C4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LELEAYAGVI SALRAQGDLT KEKKDLLGEL SKVLSISTER HRAEVRRAVN
60 70 80 90 100
DERLTTIAHN MSGPNSSSEW SIEGRRLVPL MPRLVPQTAF TVTANAVANA
110 120 130 140 150
AIQHNASLPV PAETGSKEVV VCYSYTSTTS TPTSTPVPSG SIATVKSPRP
160 170 180 190 200
ASPASNVVVL PSGSTVYVKS VSCSDEDEKP RKRRRTNSSS SSPVVLKEVP
210 220 230 240 250
KAVVPVSKTI TVPVSGSPKM SNIMQSIANS LPPHMSPVKI TFTKPSTQTT
260 270 280 290 300
NTTTQKVIIV TTSPSSTFVP NILSKSHNYA AVTKLVPTSV IASTTQKPPV
310 320 330 340 350
VITASQSSLV SSSSSGSSSS TPSPIPNTVA VTAVVSSTPS VVMSTVAQGV
360 370 380 390 400
STSAIKMAST RLPSPKSLVG APTQILAQFP KQHQQSPKQQ LHPVQQQTQQ
410 420 430 440 450
QVAQPAPVSH QQQPQQSPLP PGIKPTIQIK QESGVKIITQ QVQPSKILPK
460 470 480 490 500
PVTATLPTSS NSPIMVVSSN GAIMTTKLVT TPTGTQATYT RPTVSPSIGR
510 520 530 540 550
MAATPGAATY VKTTSGSIIT VVPKSLATLG GKIISSNIVS GTTTKITTIP
560 570 580 590 600
MTSKPNVIVV QKTTGKGTTI QGLPGKNVVT TLLNAGGEKT IQTVPTGAKP
610 620 630 640 650
AIITATRPIT KMIVTQPKGI GSTVQPAAKI IPTKIVYGQQ GKTQVLIKPK
660 670 680 690 700
PVTFQATVVS EQTRQLVTET LQQASRVAEA GNSSIQEGKE DPQSYTDSSS
710 720 730 740 750
SSTESSQSSQ DSQPVVHVIA SRRQDWSEHE IAMETSPTII YQDVSSESQS
760 770 780 790 800
ATSTIKALLE LQQTTVKEKM ESKPRQPTID LSQMAVPIQM TQEKRHSPES
810 820 830 840 850
PSIAVVESEL VAEYITTERT DEGTEVAFPL LVSHRSQPQQ PSQPQRTLLQ
860 870 880 890 900
HVAQSQTATQ TSVVVKSIPA SSPGAITHIM QQALSSHTAF TKHSEELGTE
910 920 930 940 950
EGEVEEMDTL DPQTGLFYRS ALTQSQSAKQ QKLSQPQLEQ TQLQVKTLQC
960 970 980 990 1000
FQTKQKQTIH LQADQLQHKL PQMPQLSIRH QKLTPLQQEQ AQPKPDVQHT
1010 1020 1030 1040 1050
QHPMVAKDRQ LPTLMAQSPQ TVVQVLAVKT TQQLPKLQQA PNQPKIYVQP
1060 1070 1080 1090 1100
QTPQSQMPLP AASEKQPASQ VEQPIITQGS SVTKITFEGR QPPTVTKITG
1110 1120 1130 1140 1150
GSSVPKLTSP VTSISPIQAS EKTAVSDILK MSLMEAQIDT NVEHMVVDPP
1160 1170 1180 1190 1200
KKALATSVLT GEAGSLPSTH VVVAGLANST PQQQKCRESC SSPSAAGPPL
1210 1220 1230 1240 1250
TTRKIDAPGV PTTGQFMRIQ NVGQKKAEES PAEIIIQAIP QYAIPCHSSS
1260 1270 1280 1290 1300
NVVVEPSGLL ELNNFTSQQL DDDETAMEQD IDSSTEDGTE PSPSQSSAER

S
Length:1,301
Mass (Da):138,615
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A8E3B4116A94660
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1301Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL192425 Genomic DNA Translation: EFB28715.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL192425 Genomic DNA Translation: EFB28715.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG4675 Eukaryota
ENOG410YF3T LUCA

Family and domain databases

Gene3Di1.10.1240.40, 1 hit
InterProiView protein in InterPro
IPR033482 EMSY
IPR005491 ENT_dom
IPR036142 ENT_dom-like_sf
PANTHERiPTHR16500 PTHR16500, 1 hit
PfamiView protein in Pfam
PF03735 ENT, 1 hit
SMARTiView protein in SMART
SM01191 ENT, 1 hit
SUPFAMiSSF158639 SSF158639, 1 hit
PROSITEiView protein in PROSITE
PS51138 ENT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2H1C4_AILME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2H1C4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: February 26, 2020
This is version 32 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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