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Entry version 55 (11 Dec 2019)
Sequence version 1 (09 Feb 2010)
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Protein
Submitted name:

G protein-coupled receptor 156

Gene

GPR156

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
G protein-coupled receptor 156Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR156Imported
ORF Names:PANDA_003269Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei47 – 73HelicalSequence analysisAdd BLAST27
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei125 – 144HelicalSequence analysisAdd BLAST20
Transmembranei164 – 186HelicalSequence analysisAdd BLAST23
Transmembranei224 – 247HelicalSequence analysisAdd BLAST24
Transmembranei259 – 282HelicalSequence analysisAdd BLAST24
Transmembranei288 – 310HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9646.ENSAMEP00000007336

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 332G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni426 – 540DisorderedSequence analysisAdd BLAST115
Regioni565 – 588DisorderedSequence analysisAdd BLAST24
Regioni620 – 719DisorderedSequence analysisAdd BLAST100
Regioni770 – 789DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili356 – 390Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi426 – 474PolarSequence analysisAdd BLAST49
Compositional biasi566 – 587PolarSequence analysisAdd BLAST22
Compositional biasi642 – 665PolarSequence analysisAdd BLAST24
Compositional biasi674 – 707PolarSequence analysisAdd BLAST34

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1055 Eukaryota
ENOG410XNN1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159755

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168413

KEGG Orthology (KO)

More...
KOi
K04617

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSAECTY

Database of Orthologous Groups

More...
OrthoDBi
336447at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313965

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15292 7tmC_GPR156, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR041946 GPR156_7TM

The PANTHER Classification System

More...
PANTHERi
PTHR10519 PTHR10519, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

D2H189-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPEINCSEL CDGIPGQELD RSPLHDLCRT ITSSHYSSKT ISSLSPVLLG
60 70 80 90 100
VVWTFLSCGL LLIVFFLGFT IRCRNNRIVK MSSPNLNIVT LLGSCLTYSS
110 120 130 140 150
VYLFGIQDRD ALVEGSMETL IQIRLSMLCI GTSLVFGPIL GKSWRLYKVF
160 170 180 190 200
TQRVPDKRVI IKDLQLLGLV AALVIADVIL LVTWVLTDPI QCLQILGVSM
210 220 230 240 250
TVSGRDVSCS LTSSHFCASR YSDVWIALVL VCKGLLLLYG AYLAGLTDHV
260 270 280 290 300
SSPPVNQSLT IMVGVNLVVV AAGLLFVVTR YLHSWPNLVF GLTSGGIFVC
310 320 330 340 350
TTTINCFIFI PQLKQWKAFE EENQTTRRMA KYFSTPSKSF HTPYGEEQNC
360 370 380 390 400
HTGGERNSMD RLLTEKNAMI ESLQEQVNNA KEKLVRLMSA ECTFAPSEWA
410 420 430 440 450
VPPSSSHSKN ILVAASAHNL VAQGPSECLS DSQNGTSVAA PVGSQSTSVP
460 470 480 490 500
SSSIQSLERA VKDTSSSPGQ KEKISSLKDV SEHLNLGCSQ KPWPNQSRGA
510 520 530 540 550
ERRDQVPMNP HQSLIPGGEG PVPQRQGQLE NSEEPQKRLS RVNSVIREKL
560 570 580 590 600
QEVLQDLGLG TEAPFPSSLS YPQQPWKSNS THSPQMIPLS KELGFSPYMV
610 620 630 640 650
RRRRAALRAR SHFPGSIPSY VGHRANKTGA HSGRLNVHNR DSACLDPQTA
660 670 680 690 700
DSRVPKPSSR KTSLLPDPQG KLGTMEGSKQ SQTEPQGATG SHAAFPHQPS
710 720 730 740 750
GSDWASCPTA PHLSRASPDV PEQQLLLPLG FPHCPSVSSP CNYLDTESSS
760 770 780 790 800
SDEFFCRCHR PYCEICFQSS SDSSDSGSSD SDPDPAGGLA SWEKLWARSK
810
PIVNFKDDLK PTLV
Length:814
Mass (Da):88,911
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF29245AB6D976564
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei814Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ACTA01168678 Genomic DNA No translation available.
ACTA01176676 Genomic DNA No translation available.
ACTA01184674 Genomic DNA No translation available.
GL192422 Genomic DNA Translation: EFB21178.1

NCBI Reference Sequences

More...
RefSeqi
XP_019650864.1, XM_019795305.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSAMET00000007643; ENSAMEP00000007336; ENSAMEG00000006958

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100478969

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
aml:100478969

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACTA01168678 Genomic DNA No translation available.
ACTA01176676 Genomic DNA No translation available.
ACTA01184674 Genomic DNA No translation available.
GL192422 Genomic DNA Translation: EFB21178.1
RefSeqiXP_019650864.1, XM_019795305.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000007336

Genome annotation databases

EnsembliENSAMET00000007643; ENSAMEP00000007336; ENSAMEG00000006958
GeneIDi100478969
KEGGiaml:100478969

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
165829

Phylogenomic databases

eggNOGiKOG1055 Eukaryota
ENOG410XNN1 LUCA
GeneTreeiENSGT00940000159755
HOGENOMiHOG000168413
KOiK04617
OMAiMSAECTY
OrthoDBi336447at2759
TreeFamiTF313965

Family and domain databases

CDDicd15292 7tmC_GPR156, 1 hit
InterProiView protein in InterPro
IPR002455 GPCR3_GABA-B
IPR017978 GPCR_3_C
IPR041946 GPR156_7TM
PANTHERiPTHR10519 PTHR10519, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2H189_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2H189
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: December 11, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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