Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 46 (08 May 2019)
Sequence version 1 (09 Feb 2010)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Uncharacterized protein

Gene

PANDA_000355

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PANDA_000355Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei985 – 1008HelicalSequence analysisAdd BLAST24
Transmembranei1683 – 1706HelicalSequence analysisAdd BLAST24
Transmembranei2461 – 2484HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500303180527 – 2559Sequence analysisAdd BLAST2533

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
D2GUM7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 240CAInterPro annotationAdd BLAST86
Domaini264 – 325CAInterPro annotationAdd BLAST62
Domaini450 – 535CAInterPro annotationAdd BLAST86
Domaini559 – 640CAInterPro annotationAdd BLAST82
Domaini664 – 745CAInterPro annotationAdd BLAST82
Domaini769 – 856CAInterPro annotationAdd BLAST88
Domaini886 – 967CAInterPro annotationAdd BLAST82
Domaini1096 – 1181CAInterPro annotationAdd BLAST86
Domaini1205 – 1275CAInterPro annotationAdd BLAST71
Domaini1276 – 1339CAInterPro annotationAdd BLAST64
Domaini1362 – 1443CAInterPro annotationAdd BLAST82
Domaini1467 – 1554CAInterPro annotationAdd BLAST88
Domaini1584 – 1665CAInterPro annotationAdd BLAST82
Domaini1927 – 2012CAInterPro annotationAdd BLAST86
Domaini2036 – 2117CAInterPro annotationAdd BLAST82
Domaini2140 – 2221CAInterPro annotationAdd BLAST82
Domaini2245 – 2332CAInterPro annotationAdd BLAST88
Domaini2362 – 2443CAInterPro annotationAdd BLAST82

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3594 Eukaryota
ENOG410XQHI LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220892

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030733 PCDHB15

The PANTHER Classification System

More...
PANTHERi
PTHR24028:SF97 PTHR24028:SF97, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028 Cadherin, 18 hits
PF08266 Cadherin_2, 3 hits
PF16492 Cadherin_C_2, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 18 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313 SSF49313, 20 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D2GUM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIKGELALR KRQVLILFVL LGLSQAGPES VLYSVAEETE VGSFVGNLAR
60 70 80 90 100
DLGLGVEELS SREARVVSDD NEKHLQLDLL TGDLLLNEKL DREELCGSTE
110 120 130 140 150
PCVLHFQMVL ENPLQFFRAE LHVKDINDHS PMFLDKQILI KISESTSIGT
160 170 180 190 200
TFLLESAQDL DVGTNSLQNY TISPNSHFYI KIRDSSDGKL YPELVLDRAL
210 220 230 240 250
DHEEEPELTL TLTALDGGSP PRSGTTLVLI KVLDINDNAP QFAQKLYEVH
260 270 280 290 300
VLEDTPIGSW IITIFANDLD AGNYGKISYT FLHASEDIRK TFEINPISGE
310 320 330 340 350
VHLRSCLDFE VIQFYTISIQ ATDEPWRYSV AEEMQIGSYI GNVVKDIGLG
360 370 380 390 400
VEDLVVRGAR VIFDDYKPYL QLDQQTGNLL LNEQLDREAL CHLREPCILH
410 420 430 440 450
FQVLFENPLQ FFRAELWVKD INDHTPDFLD KHILLKISEG TAPGTSFQMD
460 470 480 490 500
SAQDLDVGKN GVQNYTLSPN PYFHLKLQDS DDGRKYPELL LDQSLDREKE
510 520 530 540 550
PEFRLTLTAL DGGSPPRSGT TLVHILVLDI NDNAPEFERP VYEVQVPENS
560 570 580 590 600
PVDSLVVRVS ATDLDAGIYG ELSYSFSHVS TDIRKTFEIH SVSGEIHLKA
610 620 630 640 650
LLDFELIQSY TINIQAIDGG SLSGKSAILV QVVDVNDNAP EIVMTSLTSP
660 670 680 690 700
IPENSSPEMV VAIFSVRDQD AGDNGRMVCS IQDDLPFLLK PTFKNFYTLV
710 720 730 740 750
TEVPLDRERQ AEYNITITVT DLGTPRLKTQ HNLSVTVSDV NDNAPAFSQS
760 770 780 790 800
SYTLRVRENN SPALHIGSVS ATDRDAGANA QVTYSLLLPP HDPHLPLASL
810 820 830 840 850
VSINADNGQL FALRALDYEA LQAFEFGVRA ADRGSPALSS QALVRVLVVD
860 870 880 890 900
DNDNAPFVLY PLQNGSAPCT ELVPRAAEAG YLVTKVVAVD GDSGQNAWLS
910 920 930 940 950
YQLLKATEPG LFGVWAHNGE VRTARLLSER DAVKHRLLVL VKDNGEPPLS
960 970 980 990 1000
ASVTLHVLLV DGFSQPYLPL PDVAAAEARA DPLTVYLVIA LASVSSLFLV
1010 1020 1030 1040 1050
SVLVFVAVRL CRRSRAASEG GCAVPEGPFA GHLVDVSGTG TLSHSYQYEV
1060 1070 1080 1090 1100
CLRGGSGTEE FKFLKPAIPN LPPPEEAEMI LKIMENTLPG AVFPLKNAQD
1110 1120 1130 1140 1150
LDVGINNIQN YIIYPNSHLH VFTRNSGGGR KYPELVLDKA LDREEQPELR
1160 1170 1180 1190 1200
LTLLAVDGGV PPKTGTALVL IDILDINDNA PEFVQPLYCV QILENSPLGS
1210 1220 1230 1240 1250
LIVTVSAGDL DTGTNGEVFY SFFYGDEEIS RTFALNELTG EINLIRKLDF
1260 1270 1280 1290 1300
EKIMSYELDI KASDGAGLSG KCTVIIEASD EIKQTFSINE VTGEIRLTKK
1310 1320 1330 1340 1350
LDFEQIKSYH VEIEAIDGGG LSGKCTVVID VVDVNDNAPE LTISSLTSSV
1360 1370 1380 1390 1400
PENAPETVVS IFRIRDRDSG DNGKMICSIP DNLPFLLKPT FKNFYTLVTE
1410 1420 1430 1440 1450
SPLDRESQAE YNITITVTDL GTPRLKTQHN LSVTVSDVND NAPAFSQSSY
1460 1470 1480 1490 1500
TLRVRENNSP ALHIGSVSAT DRDAGANAQV TYSLLLPPHD PHLPLASLVS
1510 1520 1530 1540 1550
INADNGQLFA LRALDYEALQ AFEFGVRAAD RGSPALSSQA LVRVLVVDDN
1560 1570 1580 1590 1600
DNAPFVLYPL QNGSAPCTEL VPRAAEAGYL VTKVVAVDGD SGQNAWLSYQ
1610 1620 1630 1640 1650
LLKATEPGLF GVWAHNGEVR TARLLSERDA VKHRLLVLVK DNGEPPLSAS
1660 1670 1680 1690 1700
VTLHVLLVDG FSQPYLPLPD VAAAEARADP LTVYLVIALA SVSSLFLVSV
1710 1720 1730 1740 1750
LVFVAVRLCR RSRAASGGGC AVPEGPFAGH LVDVSGTGTL SHSYQYEVTE
1760 1770 1780 1790 1800
RSITVPKVEL GPVSEKAFVE VKMEAGGECF PKQRQVLILF LVLGMALAGW
1810 1820 1830 1840 1850
ESRRYSVMEE TESGSSVANL AKDLGLGVGE LAARGARVVS EDNEPRLQLD
1860 1870 1880 1890 1900
LRTGELILNE KLDREEMCGP TEPCVMHFQV LLKKPLGVFR AELLVRDIND
1910 1920 1930 1940 1950
HSPEFPEGEM TLKISENSPP GTVFPLKKAQ DLDVGKNNIQ NYSISPNSHF
1960 1970 1980 1990 2000
HVSTRTRGDG RKYPELVLDK ELDREKQAEL RLTLTALDGG SPPRSGTAQV
2010 2020 2030 2040 2050
RILVLDVNDN APEFAKTLYQ VQVPENSPVG MLVVKVSARD LDTGTNGEIS
2060 2070 2080 2090 2100
YSYFYSSQET STTFELNNLS GEVRLIKKLD FETRSSYELE IDASDGGGLS
2110 2120 2130 2140 2150
GRCSVSIEVV DVNDNYPEIT ISSLTSPIPE NSPETEVALF RIRDRDSGDN
2160 2170 2180 2190 2200
GRMTCSIQDD LPFLLKPSEE NFYTLVTNGA LDRESKALYN ITITVTDLGT
2210 2220 2230 2240 2250
PRLKTQHNLS VTVSDVNDNA PAFSQSSYTL RVRENNSPAL HIGSVSATDR
2260 2270 2280 2290 2300
DAGANAQVTY SLLLPPHDPH LPLASLVSIN ADNGQLFALR ALDYEALQAF
2310 2320 2330 2340 2350
EFGVRAADRG SPALSSQALV RVLVVDDNDN APFVLYPLQN GSAPCTELVP
2360 2370 2380 2390 2400
RAAEAGYLVT KVVAVDGDSG QNAWLSYQLL KATEPGLFGV WAHNGEVRTA
2410 2420 2430 2440 2450
RLLSERDAVK HRLLVLVKDN GEPPLSASVT LHVLLVDGFS QPYLPLPDVA
2460 2470 2480 2490 2500
AAEARADPLT VYLVIALASV SSLFLVSVLV FVAVRLCRRS RAASEGGCAV
2510 2520 2530 2540 2550
PEGPFAGHLV DVSGTGTLSH SYQYEVCLRE GSGTKEFKFL KPIFPNILSQ

DLGSHENSY
Length:2,559
Mass (Da):279,353
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE600EBE098A0D4F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL192344 Genomic DNA Translation: EFB20998.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL192344 Genomic DNA Translation: EFB20998.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiD2GUM7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3594 Eukaryota
ENOG410XQHI LUCA
HOGENOMiHOG000220892

Family and domain databases

InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR032455 Cadherin_C
IPR020894 Cadherin_CS
IPR013164 Cadherin_N
IPR030733 PCDHB15
PANTHERiPTHR24028:SF97 PTHR24028:SF97, 5 hits
PfamiView protein in Pfam
PF00028 Cadherin, 18 hits
PF08266 Cadherin_2, 3 hits
PF16492 Cadherin_C_2, 3 hits
PRINTSiPR00205 CADHERIN
SMARTiView protein in SMART
SM00112 CA, 18 hits
SUPFAMiSSF49313 SSF49313, 20 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2GUM7_AILME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2GUM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: May 8, 2019
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again