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Entry version 38 (02 Dec 2020)
Sequence version 1 (09 Feb 2010)
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Protein

AAA domain-containing protein

Gene

PANDA_000149

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AAA domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PANDA_000149Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAiluropoda melanoleuca (Giant panda)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9646 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1102 – 1336AAAInterPro annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni23 – 69DisorderedSequence analysisAdd BLAST47
Regioni148 – 184DisorderedSequence analysisAdd BLAST37
Regioni392 – 482DisorderedSequence analysisAdd BLAST91
Regioni535 – 611DisorderedSequence analysisAdd BLAST77
Regioni640 – 681DisorderedSequence analysisAdd BLAST42
Regioni957 – 1019DisorderedSequence analysisAdd BLAST63
Regioni1179 – 1209DisorderedSequence analysisAdd BLAST31
Regioni1407 – 1427DisorderedSequence analysisAdd BLAST21
Regioni1525 – 1548DisorderedSequence analysisAdd BLAST24
Regioni1566 – 1614DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 46PolarSequence analysisAdd BLAST17
Compositional biasi148 – 166PolarSequence analysisAdd BLAST19
Compositional biasi401 – 429PolyampholyteSequence analysisAdd BLAST29
Compositional biasi430 – 452PolarSequence analysisAdd BLAST23
Compositional biasi453 – 469PolyampholyteSequence analysisAdd BLAST17
Compositional biasi547 – 562PolyampholyteSequence analysisAdd BLAST16
Compositional biasi564 – 611PolarSequence analysisAdd BLAST48
Compositional biasi665 – 681PolarSequence analysisAdd BLAST17
Compositional biasi957 – 1016PolyampholyteSequence analysisAdd BLAST60
Compositional biasi1412 – 1426PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1579 – 1598PolyampholyteSequence analysisAdd BLAST20

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

D2GU56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
CKKRRKDDDR SSCKTITKYL SPIGKTGDSV FSPPKSSNIL DYFRKTSPTN
60 70 80 90 100
EKTRSAKESK MKSSAPLPAD CGKNCNTPLE MFSNLDFKKR GKRVNLSHRL
110 120 130 140 150
NNVKTENESP IKISDDSKED SSLNNDFVES STSVLLYKKR VEVLAEGSQD
160 170 180 190 200
KKQSSTMTSI KSSKKVNPKQ RITKNDCKKM RKRKHRDIID LSESLRLAEE
210 220 230 240 250
LNLHQKDGKD RKQITPSLTN EIESTANDAD SRGDITRTAH LNDSTITVSY
260 270 280 290 300
EEFLKSHKEN KAGHIPDSTV SICIPSETVE DMVKSGCVSD AETCEISQHV
310 320 330 340 350
RYKTVTVLAQ VHPIPPRKTR KIPSIFLKQK QLEMENSLSD PENEQTVQKR
360 370 380 390 400
KSNVVIQEEE LELAVLEAGS AEAVKPKCTL EERQQFMKAF RQPASDALKN
410 420 430 440 450
GVRKSSDKQK ELSEKSLNEE GRDSNSKKIT EDPNIQVVSD YGNSPSRTEK
460 470 480 490 500
GSFPNETGKK LKKKDQKMSD TGTTPGGNRQ GNIQKKAATF SFRDKQNQNR
510 520 530 540 550
LRMSLRQKKT EVFKNSTLFS SESLTCKDLA NDPLKISSPC NKKSSRKTSM
560 570 580 590 600
PVKDKVIHSE AETEDSLVNV STPKPTRKSV RTSSTPTSVV ISCTDSEEGS
610 620 630 640 650
PGKLSTPKTA NLPEKHSLYT AELITVPSDS ESPIRMKFTR ISTPKKSKKK
660 670 680 690 700
PKKRCEKSEA TDGDFTSQTR KASSASKNVS KAKQLIEKAK ALHISRSKAT
710 720 730 740 750
EEIVTPLRRS SRHQTLSEKQ LSETEDSVII IDSDYTSLKH PEKNQKKLQC
760 770 780 790 800
LNDVLGKKLS KTPKNVPGKM KVAPLFLTRK AQKTADPILG FDESSQDTPE
810 820 830 840 850
KSQDCDVQFK AKRDFLMSGL PDLLKRQIAK KAAALDVYNI ASTSFQRVVH
860 870 880 890 900
VQQKDDGCHL WHLKPPTCSL LTKLKELNTK VIDLSRCVLA LGEFSTLNSN
910 920 930 940 950
SKITNSAVGF LERRKDLTEE VRNLLLEEIS WSNPEFSLRK YFSLLLKKRS
960 970 980 990 1000
EHQLLSECHR KQESPQREPD VSQKETKRKR VETEIHKSKR KKPNEYSQSP
1010 1020 1030 1040 1050
KKINGKPEEL DKRNSSTGIK LDSYSGIEDM LWTEKYQPQN SSELIGNELA
1060 1070 1080 1090 1100
IKKLHSWLKD WKKRAELEER QNLKGKKDEK LEDLSDSIDF KGSSDDEEES
1110 1120 1130 1140 1150
RLCNTVLITG PTGVGKTAAV YACAQELGFK IFEVNASSQR SGRQILSQLK
1160 1170 1180 1190 1200
EATQSHQVDK QGVNSQKPCF FNSYNLGKSP KKLSSPKKVV TSPRKLLPPS
1210 1220 1230 1240 1250
AQTSAPKRTL PPKTLANYFK VSPKPKNNDE VVLPENYKGI KNSCEQKPVI
1260 1270 1280 1290 1300
QTQATNTTRS NVKEFGAEEP NRKNATSLIL FEEVDVIFEE DAGFLNAIKT
1310 1320 1330 1340 1350
FMATTKRPVI LTTSDPTFSL MFDGCFEEIN FSTPSLLNVA SYLQVICLAE
1360 1370 1380 1390 1400
NFRTDVKDFV TLLTANTCDI RKSILYLQFW IRSGGGFLEE RPLSLCRGNS
1410 1420 1430 1440 1450
RNVQLVCSED GPDSKNKPKN TKRSPTDLPK CDTGCVETLF GLKNILSPSE
1460 1470 1480 1490 1500
DLFSFLKHKI TTKEEWHQFI QLLTEFRKQN VDFLYSNLEF ILPLPVNIIP
1510 1520 1530 1540 1550
ETENFYGSSV SVDPSAATKN IKCLARKHSE EEKPSKKPQK KKQKKKMVVL
1560 1570 1580 1590 1600
DDSDLFDTEL DFSNEFLSPS PASSSSNSEE SKTRDKESNP ETKKLNRCSE
1610 1620 1630 1640 1650
PNLESIPRPP KTPAEKKCSA LVSHCLNSLT EFMDNMSFLD ALLTDGGERK
1660 1670 1680 1690 1700
EFGQNDFSWT NVKSGLCDEF SLENSDGWTS QSSGELKAAV EALSFTKCSS
1710 1720 1730 1740 1750
TISKALESSL NSCKKSGRDP TKELTLYVSQ KRSNVYFSQS AANLDSAWKR
1760 1770 1780 1790 1800
IAVIKSVFSS RSLLNLGNRQ ARIIEYLPTL RNICRTEKLK EQGKSKRRFL
1810 1820
HYLESIHLNI SKDTVNTLAA GFP
Length:1,823
Mass (Da):205,000
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE2691041587E0F45
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1823Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GL192339 Genomic DNA Translation: EFB26157.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL192339 Genomic DNA Translation: EFB26157.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00004, AAA, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2GU56_AILME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2GU56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: December 2, 2020
This is version 38 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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