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Protein

Zinc finger BED domain-containing protein 6

Gene

Zbed6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing the binding site.2 Publications

Miscellaneous

Encoded by an exapted DNA transposon located in an intron of the Zc3h11a gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 187BED-type 1PROSITE-ProRule annotationAdd BLAST58
Zinc fingeri265 – 322BED-type 2PROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

GO - Biological processi

  • blastocyst hatching Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger BED domain-containing protein 61 Publication
Alternative name(s):
Muscle growth regulator
Short name:
MGR
Gene namesi
Name:Zbed61 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3828086 Zbed6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003925741 – 980Zinc finger BED domain-containing protein 6Add BLAST980

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei383PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiD2EAC2
PeptideAtlasiD2EAC2
PRIDEiD2EAC2

PTM databases

iPTMnetiD2EAC2
PhosphoSitePlusiD2EAC2

Expressioni

Tissue specificityi

Shows broad tissue distribution with expression detected in brain, stomach, intestine, heart, kidney, liver, lung, skeletal muscle, ovary, spleen, tail and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000094410 Expressed in 42 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiD2EAC2 baseline and differential
GenevisibleiD2EAC2 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136026

Structurei

3D structure databases

ProteinModelPortaliD2EAC2
SMRiD2EAC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni868 – 950HATC (Hobo-Ac-Tam3) domainAdd BLAST83

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri130 – 187BED-type 1PROSITE-ProRule annotationAdd BLAST58
Zinc fingeri265 – 322BED-type 2PROSITE-ProRule annotationAdd BLAST58

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IR9U Eukaryota
ENOG410YAJD LUCA
GeneTreeiENSGT00530000063354
HOVERGENiHBG085318
InParanoidiD2EAC2
OMAiKTSAVWN
OrthoDBiEOG091G0B61
PhylomeDBiD2EAC2
TreeFamiTF322818

Family and domain databases

InterProiView protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 2 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 2 hits
SUPFAMiSSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 11 Publication (identifier: D2EAC2-1) [UniParc]FASTAAdd to basket
Also known as: Zbed6a1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVCTLSVPV SSISPGRRCS TFGDAGILGC VSINSNTDED DVVEGKMVAE
60 70 80 90 100
GANKETKLPA KKKRKKGLRI KGKRRRKKLI LAKKFSKDLG SGRPVADAPA
110 120 130 140 150
SLASGAPEQD EESLFEGNIE KQIYLPSTRA KTSIVWHFFH VDPQYTWRAI
160 170 180 190 200
CNLCEKSVSR GKPGSHLGTS TLQRHLQARH SPHWTRANKF GVTNGEEDFT
210 220 230 240 250
LDLSLSPPSP GSNGSFEYIP TDSVDENRMG KKRDKSASDA LRAKRGRFLI
260 270 280 290 300
KSNIVKHALI PGTRAKTSAV WNFFYTDPQH ISRAVCNICK RSVSRGRPGS
310 320 330 340 350
HLGTSTLQRH LQATHPIHWA VANKDSGAIG NGLDETETES SDLLNDTMPG
360 370 380 390 400
EKSSGSQDLT AEDLSDSDTD EPPCLEVENR SESPIPVADQ DNPVHAQERE
410 420 430 440 450
TTTHCENAAA NQISQAVIQM IVEDLHPYNY FSTPAFQRFL QIVAPDYRLP
460 470 480 490 500
SETYFFTKAV PQLYDSVREK IFLTLENVQS QKIHLTADIW THDPSTDYFI
510 520 530 540 550
VTVHWVSLET ASSPSNGGTP NFRKWAVLCV TGLAKDCLIT NILQELNDQI
560 570 580 590 600
GLWLSPNFLT PSFIVSDNSS NVVHAIKGGG FTHVPCFLHC LNIVIQDFFC
610 620 630 640 650
EHKSIENMLV AARKTCHHFS HSVKARQILQ EFQNDHQLPW KNLKQDETGH
660 670 680 690 700
WISTFYMLKW LLEHCYSVHH SLGRASGVVL TSLQWTLMTY VCDILKPFEE
710 720 730 740 750
ATQRVSVKTT GLNQVLPLIH HLLFSLQRLR EDFQVRGITQ ALNLVDSLSL
760 770 780 790 800
KLESDALLSA MLKSKHCILA TLLDPCFKNS LEDFFPQGAD LETYKQILAE
810 820 830 840 850
EVCNYMESSP GACQISSSET SGPLVRLGTD SFTSIKEGTS SAGSLDSSAA
860 870 880 890 900
GSVAVGSKSS LLPAAVAVVD EYFKEKYSEL SGGDDPLVYW QRKVSIWPAL
910 920 930 940 950
TQVAIQYLSC PMCSWQSECM FTTNSHFHPK QIMNMDFDNI EQLIFLKMNL
960 970 980
ENVNYDYSTL ILSWDPENKA VQSNEKEILP
Length:980
Mass (Da):109,152
Last modified:February 9, 2010 - v1
Checksum:iB57559C15367A9DF
GO
Isoform 21 Publication (identifier: D2EAC2-2) [UniParc]FASTAAdd to basket
Also known as: Zbed6b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Show »
Length:934
Mass (Da):104,465
Checksum:iA9B426A9F0AC6C9F
GO

Sequence cautioni

The sequence BAC41160 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti574H → Q in BAE26165 (PubMed:16141072).Curated1
Sequence conflicti901T → I in BAC41160 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0532061 – 46Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM882123 mRNA Translation: CAT02778.1
FM882123 mRNA Translation: CAT02779.1
AK035705 mRNA Translation: BAC29161.1
AK090300 mRNA Translation: BAC41160.1 Different initiation.
AK144981 mRNA Translation: BAE26165.1
AC124338 Genomic DNA No translation available.
CCDSiCCDS56643.1 [D2EAC2-1]
RefSeqiNP_001160024.1, NM_001166552.1 [D2EAC2-1]
UniGeneiMm.245357
Mm.489075

Genome annotation databases

EnsembliENSMUST00000179598; ENSMUSP00000136026; ENSMUSG00000094410 [D2EAC2-1]
ENSMUST00000186476; ENSMUSP00000139417; ENSMUSG00000094410 [D2EAC2-1]
ENSMUST00000190574; ENSMUSP00000140892; ENSMUSG00000102049 [D2EAC2-1]
GeneIDi667118
KEGGimmu:667118
UCSCiuc007cqr.2 mouse [D2EAC2-1]

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM882123 mRNA Translation: CAT02778.1
FM882123 mRNA Translation: CAT02779.1
AK035705 mRNA Translation: BAC29161.1
AK090300 mRNA Translation: BAC41160.1 Different initiation.
AK144981 mRNA Translation: BAE26165.1
AC124338 Genomic DNA No translation available.
CCDSiCCDS56643.1 [D2EAC2-1]
RefSeqiNP_001160024.1, NM_001166552.1 [D2EAC2-1]
UniGeneiMm.245357
Mm.489075

3D structure databases

ProteinModelPortaliD2EAC2
SMRiD2EAC2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136026

PTM databases

iPTMnetiD2EAC2
PhosphoSitePlusiD2EAC2

Proteomic databases

PaxDbiD2EAC2
PeptideAtlasiD2EAC2
PRIDEiD2EAC2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000179598; ENSMUSP00000136026; ENSMUSG00000094410 [D2EAC2-1]
ENSMUST00000186476; ENSMUSP00000139417; ENSMUSG00000094410 [D2EAC2-1]
ENSMUST00000190574; ENSMUSP00000140892; ENSMUSG00000102049 [D2EAC2-1]
GeneIDi667118
KEGGimmu:667118
UCSCiuc007cqr.2 mouse [D2EAC2-1]

Organism-specific databases

CTDi100381270
MGIiMGI:3828086 Zbed6

Phylogenomic databases

eggNOGiENOG410IR9U Eukaryota
ENOG410YAJD LUCA
GeneTreeiENSGT00530000063354
HOVERGENiHBG085318
InParanoidiD2EAC2
OMAiKTSAVWN
OrthoDBiEOG091G0B61
PhylomeDBiD2EAC2
TreeFamiTF322818

Miscellaneous databases

PROiPR:D2EAC2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000094410 Expressed in 42 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiD2EAC2 baseline and differential
GenevisibleiD2EAC2 MM

Family and domain databases

InterProiView protein in InterPro
IPR037220 BED_dom
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR003656 Znf_BED
IPR036236 Znf_C2H2_sf
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF02892 zf-BED, 2 hits
SMARTiView protein in SMART
SM00614 ZnF_BED, 2 hits
SUPFAMiSSF140996 SSF140996, 1 hit
SSF53098 SSF53098, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50808 ZF_BED, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBED6_MOUSE
AccessioniPrimary (citable) accession number: D2EAC2
Secondary accession number(s): D2EAC3
, Q3UMD3, Q8C1U4, Q8CBM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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