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Protein

Conotoxin Lt6.4

Gene
N/A
Organism
Conus litteratus (Lettered cone)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionToxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin Lt6.4
OrganismiConus litteratus (Lettered cone)
Taxonomic identifieri89445 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusElisaconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000039216220 – 42Sequence analysisAdd BLAST23
PeptideiPRO_000039216343 – 81Conotoxin Lt6.4Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 60By similarity
Disulfide bondi53 ↔ 65By similarity
Disulfide bondi59 ↔ 80By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiD2DGD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similaritiesi

Belongs to the conotoxin I3 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D2DGD9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLVLAIVLI LMFLSLSAGA ETSDNGVSRG GHRPQYWPVT PPSIVCLRSG
60 70 80
EDCENNTPCC PGLSCRVSAD LATLKLSLAC D
Length:81
Mass (Da):8,564
Last modified:February 9, 2010 - v1
Checksum:i55D8AF3B2F2A0D4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ531700 mRNA Translation: ACU30046.1

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ531700 mRNA Translation: ACU30046.1

3D structure databases

SMRiD2DGD9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiI364_CONLT
AccessioniPrimary (citable) accession number: D2DGD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: February 9, 2010
Last modified: October 10, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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