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Protein

Pyruvate kinase

Gene

Tnap_0838

Organism
Thermotoga naphthophila (strain ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (Tnap_0838)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Ordered Locus Names:Tnap_0838Imported
OrganismiThermotoga naphthophila (strain ATCC BAA-489 / DSM 13996 / JCM 10882 / RKU-10)Imported
Taxonomic identifieri590168 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000000940 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliD2C7J4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 338PKInterPro annotationAdd BLAST338
Domaini351 – 463PK_CInterPro annotationAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili415 – 435Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000021558
KOiK00873
OMAiICVEAEK

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit

Sequencei

Sequence statusi: Complete.

D2C7J4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNTKIVCTV GPRTDSYEMI EKMIDLGVNV FRINTSHGDW NEQEQKILKI
60 70 80 90 100
KELREKKKKP VAVLIDLAGP KIRTGYLEKE FVELKEGQIF TLTTKEILGN
110 120 130 140 150
EHMVSVNLSS LPQDVKKGDT ILLSDGEIVL EVIETTDTEV KTVVKVGGKI
160 170 180 190 200
THRRGVNVPT ADLSVESITD RDREFIKLGT LHNVEFFALS FVRKPEDVLK
210 220 230 240 250
AKEEIRKHGS EIPVISKIET KKALERLEEI IKVSDGIMVA RGDLGVEIPI
260 270 280 290 300
EEVPIVQKEI IKLSKYYSKP VIVATQILES MIENPFPTRA EVTDIANAIF
310 320 330 340 350
DGADALLLTA ETAVGKHPLE AIKVLSKVAE EAEKKLEFFR TIEYDTSDIS
360 370 380 390 400
EAISHACWQL SESLNAKLII TPTISGSTAI RVSKYNVSQP IVALTPEEKT
410 420 430 440 450
YYRLSLVRKV IPVLAEKCSQ ELEFIEKGLK KVEEMGLAEK GDLVVLTSGV
460
PGKVGTTNTI RVLRVD
Length:466
Mass (Da):51,938
Last modified:February 9, 2010 - v1
Checksum:iB347E016E3AA046E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001839 Genomic DNA Translation: ADA66930.1
RefSeqiWP_011943319.1, NC_013642.1

Genome annotation databases

EnsemblBacteriaiADA66930; ADA66930; Tnap_0838
GeneIDi29652890
KEGGitnp:Tnap_0838

Similar proteinsi

Entry informationi

Entry nameiD2C7J4_THENR
AccessioniPrimary (citable) accession number: D2C7J4
Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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