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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Streptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSROS479432:G1GGL-7801-MONOMER
UniPathwayi
UPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Sros_8012
OrganismiStreptosporangium roseum (strain ATCC 12428 / DSM 43021 / JCM 3005 / NI 9100)
Taxonomic identifieri479432 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptosporangialesStreptosporangiaceaeStreptosporangium
Proteomesi
  • UP000002029 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987181 – 2222-phospho-L-lactate guanylyltransferaseAdd BLAST222

Proteomic databases

PRIDEiD2AVM1

Interactioni

Protein-protein interaction databases

STRINGi479432.Sros_8012

Structurei

3D structure databases

SMRiD2AVM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0 Bacteria
COG1920 LUCA
HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

D2AVM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKAMPASES SGWTLVVPVK TLVAAKTRLS EAAGPHRAAL AVAIACDTVE
60 70 80 90 100
AALSCVIVAR IVVVTGDPLA AEALGGVGAH VVGDPEAGLN AALRRGAQEA
110 120 130 140 150
VRLAPGDAVG ALQADLPALR PAELALVLTA AAEFEQAFLP DAADVGTTFY
160 170 180 190 200
GVRPGVPFTP GFGGESRDRH LRRGAKEICL DGIDSVRRDV DTPDDLRAAL
210 220
ALGLGPRTLA MVERIRGGFP SP
Length:222
Mass (Da):22,725
Last modified:February 9, 2010 - v1
Checksum:i41F31D25A42C6B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001814 Genomic DNA Translation: ACZ90667.1
RefSeqiWP_012894397.1, NC_013595.1

Genome annotation databases

EnsemblBacteriaiACZ90667; ACZ90667; Sros_8012
KEGGisro:Sros_8012

Similar proteinsi

Entry informationi

Entry nameiCOFC_STRRD
AccessioniPrimary (citable) accession number: D2AVM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: February 9, 2010
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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