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UniProtKB - D2A0V0 (D2A0V0_TRICA)

Entry version 67 (02 Dec 2020)
Sequence version 1 (09 Feb 2010)
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Protein
Submitted name:

Chromatin-remodeling complex ATPase chain Iswi-like Protein

Gene

TcasGA2_TC007199

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Chromatin-remodeling complex ATPase chain Iswi-like ProteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TcasGA2_TC007199Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTribolium castaneum (Red flour beetle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7070 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Coleoptera › Polyphaga › Cucujiformia › Tenebrionidae › Tenebrionidae incertae sedis › Tribolium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Linkage group 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7070.TC007199-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini136 – 301Helicase ATP-bindingInterPro annotationAdd BLAST166
Domaini431 – 582Helicase C-terminalInterPro annotationAdd BLAST152
Domaini787 – 839SANTInterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni57 – 102DisorderedSequence analysisAdd BLAST46
Regioni756 – 775DisorderedSequence analysisAdd BLAST20
Regioni962 – 1011DisorderedSequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 27PolarSequence analysisAdd BLAST17
Compositional biasi72 – 102PolyampholyteSequence analysisAdd BLAST31
Compositional biasi962 – 976PolyampholyteSequence analysisAdd BLAST15
Compositional biasi977 – 998PolarSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0385, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000315_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		D2A0V0

Identification of Orthologs from Complete Genome Data

More...OMAi		QEIYYFR

Database of Orthologous Groups

More...OrthoDBi		61251at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		D2A0V0

Family and domain databases

Conserved Domains Database

More...CDDi		cd00167, SANT, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1040.30, 1 hit
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR020838, DBINO
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR029915, ISWI_metazoa
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

The PANTHER Classification System

More...PANTHERi		PTHR10799:SF819, PTHR10799:SF819, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13892, DBINO, 1 hit
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D2A0V0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKVEEGGET ADTGENSNAS SSDTLSSRGK GEDFETKLET DRSRRFDYLL 
        60         70         80         90        100
KQTEIFSHFM NQNKTPSKPK SGRPKKIKED PVADHRHRKT EQEEDEELLA 
       110        120        130        140        150
ESNAKAKPTI RFEASPPFIK NGEMRDYQIR GLNWMVSLYE NGINGILADE 
       160        170        180        190        200
MGLGKTLQTI SLLGFMKHYK NTPSPHIVIV PKSTLANWMN EFKKWCPSIR 
       210        220        230        240        250
AVCLIGDQEA RNAFIRDVMM PGDWDVCVTS YEMVIKEKSV FKKFNWRYMV 
       260        270        280        290        300
IDEAHRIKNE KSKLSEILRE FKTTNRLLLT GTPLQNNLHE LWALLNFLLP 
       310        320        330        340        350
DVFNSADDFD AWFNTNQCLG DNQLVERLHA VLKPFLLRRL KSEVEKKLKP 
       360        370        380        390        400
KKELKVYVGL SKMQREWYTK VLMKDIDVVN GAGKVEKMRL QNILMQLRKC 
       410        420        430        440        450
SNHPYLFDGA EPGPPYTTDE HLVYNCGKMV LLDKLLPKLK EQDSRVLIFS 
       460        470        480        490        500
QMTRMLDILE DYCHWRQYNY CRLDGQTPHE DRQRQINEYN EPNSSKFIFM 
       510        520        530        540        550
LSTRAGGLGI NLATADVVII YDSDWNPQMD LQAMDRAHRI GQKKQVRVFR 
       560        570        580        590        600
LITENTVEEK IVERAEVKLR LDKLVIQQGR LIDNKSQSLN KDEMLNMIRH 
       610        620        630        640        650
GANHVFASKD SEITDEDIDT ILQKGEAKTA ELAQKLEALG ESSLRNFTVD 
       660        670        680        690        700
TPTESVYKFE GEDYREKQKN IGLNTWIEPP KRERKANYAV DAYFREALRV 
       710        720        730        740        750
SEPKAPKAPR PPKQPIVQDF QFFPPRLFEL LDQEIYYYRK TLGYKVPKNL 
       760        770        780        790        800
ELGPEAAKQQ REEQRKIDES EMLTEEEQQE KEALLTQGFT NWSKRDFNQF 
       810        820        830        840        850
IKANEKYGRD DIENIAKEVE GKTPEEVMEY SAVFWERCHE LQDIDRIMAQ 
       860        870        880        890        900
IERGETKIQR RASIKKALDA KMARYRAPFH QLRIAYGTNK GKNYMEDEDR 
       910        920        930        940        950
FLVCMLHRLG FDRENVYEEL RAAVRASPQF RFDWFLKSRT AMELQRRCNT 
       960        970        980        990       1000
LITLIERENA ELEEKERNER KKKVSKSNAI SGTPTQVSSK SGQKRKNDST 
      1010 
GGAVEKKKKK K
Length:1,011
Mass (Da):117,845
Last modified:February 9, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35F2BFF09C606E68
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KQ971338 Genomic DNA Translation: EFA01629.1

NCBI Reference Sequences

More...RefSeqi		XP_972116.1, XM_967023.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		TC007199_001; TC007199_001; TC007199

Database of genes from NCBI RefSeq genomes

More...GeneIDi		660820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		tca:660820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ971338 Genomic DNA Translation: EFA01629.1
RefSeqiXP_972116.1, XM_967023.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7070.TC007199-PA

Genome annotation databases

EnsemblMetazoaiTC007199_001; TC007199_001; TC007199
GeneIDi660820
KEGGitca:660820

Phylogenomic databases

eggNOGiKOG0385, Eukaryota
HOGENOMiCLU_000315_0_0_1
InParanoidiD2A0V0
OMAiQEIYYFR
OrthoDBi61251at2759
PhylomeDBiD2A0V0

Family and domain databases

CDDicd00167, SANT, 1 hit
Gene3Di1.10.1040.30, 1 hit
3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR020838, DBINO
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR009057, Homeobox-like_sf
IPR015194, ISWI_HAND-dom
IPR036306, ISWI_HAND-dom_sf
IPR029915, ISWI_metazoa
IPR027417, P-loop_NTPase
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR015195, SLIDE
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PANTHERiPTHR10799:SF819, PTHR10799:SF819, 1 hit
PfamiView protein in Pfam
PF13892, DBINO, 1 hit
PF09110, HAND, 1 hit
PF00271, Helicase_C, 1 hit
PF09111, SLIDE, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00717, SANT, 2 hits
SUPFAMiSSF101224, SSF101224, 1 hit
SSF46689, SSF46689, 2 hits
SSF52540, SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51293, SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD2A0V0_TRICA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D2A0V0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: February 9, 2010
Last sequence update: February 9, 2010
Last modified: December 2, 2020
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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