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Entry version 62 (03 Jul 2019)
Sequence version 1 (19 Jan 2010)
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Protein
Submitted name:

CRISPR-associated helicase Cas3

Gene

Tter_1895

Organism
Thermobaculum terrenum (strain ATCC BAA-798 / YNP1)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
TTER525904:G1GGS-1950-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CRISPR-associated helicase Cas3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:Tter_1895Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiThermobaculum terrenum (strain ATCC BAA-798 / YNP1)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri525904 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaThermobaculum
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000323 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

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STRINGi
525904.Tter_1895

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
D1CGD0

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 239HD Cas3-typeInterPro annotationAdd BLAST198

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4105DTT Bacteria
COG1203 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015796

KEGG Orthology (KO)

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KOi
K07012

Identification of Orthologs from Complete Genome Data

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OMAi
CWIRNTV

Database of Orthologous Groups

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OrthoDBi
1149839at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.3210.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR035011 Cas3
IPR041372 Cas3_C
IPR006483 CRISPR-assoc_Cas3_HD
IPR038257 CRISPR-assoc_Cas3_HD_sf
IPR014001 Helicase_ATP-bd
IPR006474 Helicase_Cas3_CRISPR-ass_core
IPR027417 P-loop_NTPase

The PANTHER Classification System

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PANTHERi
PTHR24031:SF596 PTHR24031:SF596, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF18395 Cas3_C, 1 hit
PF18019 HD_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01587 cas3_core, 1 hit
TIGR01596 cas3_HD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51643 HD_CAS3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D1CGD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGGPGMDGT SEVDLSGAGS PVGAAGWRVD PWIFWAKWGS GPDLGWHPLL
60 70 80 90 100
CHMLDVAAVT LQMWRRVLPA AWKARISGVL GVGQEDAERW LAFFAGGHDI
110 120 130 140 150
GKASPAFQLQ LRPEQGRELV ARRLRDAGLP LFNARAPHGT ISANVLETVL
160 170 180 190 200
ADVFGLSGRS ARWVAFAVGG HHGFVPSYDE VRRDLDQQAV GWGMWDAARE
210 220 230 240 250
VLLCRLADAL GLPGSSRPTV ESTPDAFMLA GLVSVADWIG SNEEYFPYAA
260 270 280 290 300
QSALQVPQLD AEAYLERAMR QAERAMASLG WVGWRPASGS MRLTELFPYI
310 320 330 340 350
RQPTTVQAAA EELAGEVKSP SITIIEAPMG EGKTEAAMLL ADTFSTAHGM
360 370 380 390 400
SGCYFALPTM ATSNQMFGRV TDYLRHRYPE DVVVVNLVHG HSDLSALLQE
410 420 430 440 450
LRQKGEEIFQ LQGVYDEALG DEQLGAVVAG QWFTRGKRAL LPPYGVGTVD
460 470 480 490 500
QALLAVLQVK HVFVRLFALS TKTVIVDEVH AYDVYMTTLL HRLLEWLGAL
510 520 530 540 550
SVPVVVLSAT LPSARRRELV KAYARGAGWQ AERDLPPAGY PRITYAAAED
560 570 580 590 600
VRGIHFAPSE ASRRKVALRW VSAPEHEALG QLLAEALSQG GCAAIICNTV
610 620 630 640 650
PRAQALYSAL REVFPGLAED GMPELDLLHA RYPYEEREVR EARTLGRFSR
660 670 680 690 700
NGRRPHRAIL VATQVIEQSL DLDFDLMVTD LAPVDLVLQR MGRLHRHPVH
710 720 730 740 750
DPLRPERLRS PELWVVSPQV MGDVPIFDRG SASVYDEHTL LRSWLALRDR
760 770 780 790 800
DTLQLPEDIE ELVEQVYSDG RVPQGASEEL RSLWERTFKA QQKVLREDSL
810 820 830 840 850
QAKYRYIKGP GYNSIWGIVT ASVEEDAPEL HPALQALTRL AEPSVSAVCL
860 870 880 890 900
VAGSGGPCLP DGTPVDLDTP PDAAMAERLL RRSVAITDAR VLDPLLDVPV
910 920 930 940
PKGWERSSLL RGYRPLVFDA SGRAMVGRWI VRIDPELGIV VESP
Length:944
Mass (Da):103,764
Last modified:January 19, 2010 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E8C55F810FE1BB5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP001826 Genomic DNA Translation: ACZ42801.1

NCBI Reference Sequences

More...
RefSeqi
WP_012875832.1, NC_013526.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACZ42801; ACZ42801; Tter_1895

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ttr:Tter_1895

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001826 Genomic DNA Translation: ACZ42801.1
RefSeqiWP_012875832.1, NC_013526.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q2CX-ray2.50A1-944[»]
4Q2DX-ray2.77A1-944[»]
SMRiD1CGD0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi525904.Tter_1895

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACZ42801; ACZ42801; Tter_1895
KEGGittr:Tter_1895

Phylogenomic databases

eggNOGiENOG4105DTT Bacteria
COG1203 LUCA
HOGENOMiHOG000015796
KOiK07012
OMAiCWIRNTV
OrthoDBi1149839at2

Enzyme and pathway databases

BioCyciTTER525904:G1GGS-1950-MONOMER

Family and domain databases

Gene3Di1.10.3210.30, 1 hit
InterProiView protein in InterPro
IPR035011 Cas3
IPR041372 Cas3_C
IPR006483 CRISPR-assoc_Cas3_HD
IPR038257 CRISPR-assoc_Cas3_HD_sf
IPR014001 Helicase_ATP-bd
IPR006474 Helicase_Cas3_CRISPR-ass_core
IPR027417 P-loop_NTPase
PANTHERiPTHR24031:SF596 PTHR24031:SF596, 1 hit
PfamiView protein in Pfam
PF18395 Cas3_C, 1 hit
PF18019 HD_6, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01587 cas3_core, 1 hit
TIGR01596 cas3_HD, 1 hit
PROSITEiView protein in PROSITE
PS51643 HD_CAS3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD1CGD0_THET1
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D1CGD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: July 3, 2019
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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