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Protein

Argininosuccinate synthase

Gene

argG

Organism
Sphaerobacter thermophilus (strain DSM 20745 / S 6022)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG), Argininosuccinate synthase (Sthe_0206)
  3. Argininosuccinate lyase (argH), Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei90CitrullineUniRule annotation1
Binding sitei95CitrullineUniRule annotation1
Binding sitei120ATP; via amide nitrogenUniRule annotation1
Binding sitei122AspartateUniRule annotation1
Binding sitei126AspartateUniRule annotation1
Binding sitei126CitrullineUniRule annotation1
Binding sitei127AspartateUniRule annotation1
Binding sitei130CitrullineUniRule annotation1
Binding sitei179CitrullineUniRule annotation1
Binding sitei188CitrullineUniRule annotation1
Binding sitei264CitrullineUniRule annotation1
Binding sitei276CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSTHE479434:G1GGR-3266-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Sthe_3259Imported
OrganismiSphaerobacter thermophilus (strain DSM 20745 / S 6022)Imported
Taxonomic identifieri479434 [NCBI]
Taxonomic lineageiBacteriaChloroflexiSphaerobacteridaeSphaerobacteralesSphaerobacterineaeSphaerobacteraceaeSphaerobacter
Proteomesi
  • UP000002027 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi479434.Sthe_3259

Structurei

3D structure databases

ProteinModelPortaliD1CA16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CDH Bacteria
COG0137 LUCA
HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

D1CA16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPEVNKVV LAYSGGLDTS VILAWIKEHY GCEVIAFTAD VGQGDSFEGL
60 70 80 90 100
EAKALASGAS KLYVRDLKEE FLTKYAFPTL RAGAVYERKY LLGTSFARPL
110 120 130 140 150
IASHQVEIAR LEGADAVAHG CTGKGNDQVR FELTFQALAP DLKVIAPWRQ
160 170 180 190 200
WDLGGREELL EYAVARGIPV SQSKTNIYSR DQNLWHLSHE GGELEDPWQE
210 220 230 240 250
PNEAMYQITV SPEEAPDKPV EIVIGFEQGY PVSLDGTPMG PVELVTTLNK
260 270 280 290 300
IGGEHGVGRI DLVENRLVGM KSHGVYEQPG AAILSTAHKE LESITLDRET
310 320 330 340 350
LHYKDLVAQK YAELVYDGRW FTPLREALDA FVEVTQQPVT GEVRLKLYKG
360 370 380 390 400
NIIPTGRKSP YSLYHEGFAT FGADDVYNQA DAKGFINLFG LPMKVAALAK

QKREGADGK
Length:409
Mass (Da):45,076
Last modified:January 19, 2010 - v1
Checksum:iCD597A544F713A7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001824 Genomic DNA Translation: ACZ40659.1
RefSeqiWP_012873694.1, NC_013524.1

Genome annotation databases

EnsemblBacteriaiACZ40659; ACZ40659; Sthe_3259
KEGGisti:Sthe_3259

Similar proteinsi

Entry informationi

Entry nameiD1CA16_SPHTD
AccessioniPrimary (citable) accession number: D1CA16
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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