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Protein

Alanine racemase

Gene

Vpar_0249

Organism
Veillonella parvula (strain ATCC 10790 / DSM 2008 / JCM 12972 / Te3) (Veillonella alcalescens)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Vpar_0249)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Active sitei263Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei311Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Vpar_0249Imported
OrganismiVeillonella parvula (strain ATCC 10790 / DSM 2008 / JCM 12972 / Te3) (Veillonella alcalescens)Imported
Taxonomic identifieri479436 [NCBI]
Taxonomic lineageiBacteriaFirmicutesNegativicutesVeillonellalesVeillonellaceaeVeillonella
Proteomesi
  • UP000007968 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi479436.Vpar_0249

Structurei

3D structure databases

ProteinModelPortaliD1BQX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 370Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

D1BQX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPTYLTINT SLVRENLRKI KDSLPEWSTS TAVIKANGYG HGSVMMGRIA
60 70 80 90 100
VEEGYESLAV AIPEESVPLR NAGIMVPIYL LGLTRPQSFE LVADTNSIPA
110 120 130 140 150
VCESTDLESL NKVADNHDMI IRVAVAVDTG MHRIGIKPED AIEFIKRIES
160 170 180 190 200
YENLEIDGFF SHMSNADAAD QSHAHSQTQK FHRMVDEIRA FRPEADYRFS
210 220 230 240 250
LANSAGLLSV KDSLFTDARP GIIQYGIMPS LDVPNRLGLK PVLSFHSEVV
260 270 280 290 300
HVQHIPAGEG IGYGSTYITT EPMTIATIPV GYADGYPRSL SNRGTVLIHG
310 320 330 340 350
TRCPVVGRIC MDQFMVSVPD TITVKPGDKV VLLGSQGHES ISALEIAALA
360 370
STIPYEIFCG FSERVPRQYI
Length:370
Mass (Da):40,562
Last modified:January 19, 2010 - v1
Checksum:iAC39719561BCE3BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001820 Genomic DNA Translation: ACZ23935.1
RefSeqiWP_004697849.1, NC_013520.1

Genome annotation databases

EnsemblBacteriaiACZ23935; ACZ23935; Vpar_0249
GeneIDi8635693
KEGGivpr:Vpar_0249
PATRICifig|479436.6.peg.241

Similar proteinsi

Entry informationi

Entry nameiD1BQX2_VEIPT
AccessioniPrimary (citable) accession number: D1BQX2
Entry historyiIntegrated into UniProtKB/TrEMBL: January 19, 2010
Last sequence update: January 19, 2010
Last modified: June 20, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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