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Protein

Laccase

Gene
N/A
Organism
Trametes maxima (White-rot fungus) (Cerrena maxima)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.Curated2 Publications

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.2 Publications

Cofactori

Cu cation2 PublicationsNote: Binds 4 Cu cations per monomer.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Copper 1; type 21
Metal bindingi66Copper 2; type 31
Metal bindingi109Copper 2; type 31
Metal bindingi111Copper 3; type 31
Metal bindingi395Copper 4; type 11
Metal bindingi398Copper 1; type 21
Metal bindingi400Copper 3; type 31
Metal bindingi452Copper 3; type 31
Metal bindingi453Copper 4; type 11
Metal bindingi454Copper 2; type 31
Metal bindingi458Copper 4; type 11

GO - Molecular functioni

GO - Biological processi

  • lignin catabolic process Source: UniProtKB

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase2 PublicationsImported (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductaseBy similarity
Diphenol oxidaseBy similarity
Urishiol oxidaseBy similarity
OrganismiTrametes maxima (White-rot fungus) (Cerrena maxima)
Taxonomic identifieri259368 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesPolyporaceaeTrametes

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004011491 – 499LaccaseAdd BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi54N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi85 ↔ 4882 Publications
Disulfide bondi117 ↔ 2052 Publications
Modified residuei1963'-nitrotyrosine3 Publications1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi217N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei3723'-nitrotyrosine3 Publications1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration

PTM databases

iPTMnetiD0VWU3

Structurei

Secondary structure

1499
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiD0VWU3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWU3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 127Plastocyanin-like 1Add BLAST126
Domaini139 – 281Plastocyanin-like 2Add BLAST143
Domaini348 – 470Plastocyanin-like 3Add BLAST123

Sequence similaritiesi

Belongs to the multicopper oxidase family.Sequence analysis

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit

Sequencei

Sequence statusi: Complete.

D0VWU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AVGPVADNTI TDAATSPDGF SRQAVVVNGV TPGPLVAGNI GDRFQLNVID
60 70 80 90 100
NLTNHTMLKT TSVHWHGFFQ QGTNWADGPA FINQCPISPG HSFLYDFQVP
110 120 130 140 150
NQAGTFWYHS HLSTQYCDGL RGPFVVYDPN DPHASRYDVD NDDTVITLAD
160 170 180 190 200
WYHTAAKLGP RFPAGADATL INGKGRAPSD TSAELSVIKV TKGKRYRFRL
210 220 230 240 250
VSLSCDPNFT FSIDGHNLTI IEVDSSNSQP LSVDSIQIFA AQRYSFVLNA
260 270 280 290 300
NQAVDNYWIR ANPNFGNVGF NGGINSAILR YDGAPAVEPT TNQTTSVKPL
310 320 330 340 350
NEVNLHPLVS TPVPGSPSSG GVDKAINMAF NFNGSNFFIN GASFVPPSVP
360 370 380 390 400
VLLQILSGAQ TAQDLLPSGS VYVLPSNASI EISFPATAAA PGAPHPFHLH
410 420 430 440 450
GHTFAVVRSA GSTVYNYSNP IFRDVVSTGT PAAGDNVTIR FLTNNPGPWF
460 470 480 490
LHCHIDFHLE GGFAVVQAED VPDVKATNPV PQAWSDLCPT YDANAPSDQ
Length:499
Mass (Da):53,451
Last modified:December 15, 2009 - v1
Checksum:iF018B0357333CF33
GO

Similar proteinsi

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H5UX-ray1.90A2-499[»]
3DIVX-ray1.76A1-499[»]
SMRiD0VWU3
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiD0VWU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiD0VWU3

Family and domain databases

Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR008972 Cupredoxin
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAC1_TRAMX
AccessioniPrimary (citable) accession number: D0VWU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: December 15, 2009
Last modified: October 25, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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