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Protein

Piezo-type mechanosensitive ion channel component

Gene

pezo-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel componentUniRule annotation
Gene namesi
Name:pezo-1Imported
ORF Names:C10C5.1Imported, CELE_C10C5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC10C5.1c ; CE49745 ; WBGene00007505 ; pezo-1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 45HelicalUniRule annotationAdd BLAST26
Transmembranei57 – 81HelicalUniRule annotationAdd BLAST25
Transmembranei122 – 143HelicalUniRule annotationAdd BLAST22
Transmembranei175 – 199HelicalUniRule annotationAdd BLAST25
Transmembranei211 – 229HelicalUniRule annotationAdd BLAST19
Transmembranei241 – 264HelicalUniRule annotationAdd BLAST24
Transmembranei307 – 325HelicalUniRule annotationAdd BLAST19
Transmembranei454 – 473HelicalUniRule annotationAdd BLAST20
Transmembranei479 – 499HelicalUniRule annotationAdd BLAST21
Transmembranei506 – 527HelicalUniRule annotationAdd BLAST22
Transmembranei551 – 573HelicalUniRule annotationAdd BLAST23
Transmembranei627 – 648HelicalUniRule annotationAdd BLAST22
Transmembranei654 – 671HelicalUniRule annotationAdd BLAST18
Transmembranei683 – 703HelicalUniRule annotationAdd BLAST21
Transmembranei740 – 758HelicalUniRule annotationAdd BLAST19
Transmembranei819 – 840HelicalUniRule annotationAdd BLAST22
Transmembranei846 – 861HelicalUniRule annotationAdd BLAST16
Transmembranei868 – 887HelicalUniRule annotationAdd BLAST20
Transmembranei930 – 951HelicalUniRule annotationAdd BLAST22
Transmembranei1041 – 1062HelicalUniRule annotationAdd BLAST22
Transmembranei1103 – 1122HelicalUniRule annotationAdd BLAST20
Transmembranei1163 – 1182HelicalUniRule annotationAdd BLAST20
Transmembranei1188 – 1207HelicalUniRule annotationAdd BLAST20
Transmembranei1228 – 1250HelicalUniRule annotationAdd BLAST23
Transmembranei1617 – 1641HelicalUniRule annotationAdd BLAST25
Transmembranei1653 – 1676HelicalUniRule annotationAdd BLAST24
Transmembranei1707 – 1725HelicalUniRule annotationAdd BLAST19
Transmembranei1829 – 1848HelicalUniRule annotationAdd BLAST20
Transmembranei1868 – 1890HelicalUniRule annotationAdd BLAST23
Transmembranei1899 – 1917HelicalUniRule annotationAdd BLAST19
Transmembranei2041 – 2065HelicalUniRule annotationAdd BLAST25
Transmembranei2349 – 2370HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

EPDiD0VWN8
PeptideAtlasiD0VWN8

Expressioni

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Structurei

3D structure databases

ProteinModelPortaliD0VWN8
SMRiD0VWN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1242 – 1457PIEZOInterPro annotationAdd BLAST216
Domaini1980 – 2433Piezo_RRas_bdgInterPro annotationAdd BLAST454

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1346 – 1366Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PIEZO (TC 1.A.75) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00390000013029
HOGENOMiHOG000022123

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

D0VWN8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVPPLLKSC VVKLLLPAAL LAAAIIRPSF LSIGYVLLAL VSAVLPPIRK
60 70 80 90 100
SLALPKLVGT FVIITFLFCL AVALGVGSYQ ISEQVVHKND RTYICNRSDT
110 120 130 140 150
TLFRSIGLVR FHPTGTFEST RAFLPEIIAT SAALLTIIIV MFLSHRDEQL
160 170 180 190 200
DVVGDVVTVR SESGREQRRQ RKLAAIMWSA IGNSLRRLTN FVLFLFTAYV
210 220 230 240 250
GIVKPSLSNS IYFLAFLFIS TWWSTYTPLR HGVYNQIKKF LIFYSALHFL
260 270 280 290 300
VLYTYQIPIV HHSWLPTGSF LPRLFGLTVL MDSSCPEWWK FPFVAPDFND
310 320 330 340 350
DDLIMKWPLY ANPIVVLVFF YLTVAQYKFT RNGSREYIDD NEYGSSVHEE
360 370 380 390 400
RFVSAGTVET NVDDVGQLIS ISESTASAPS GRGRGNTLLL SNASSSANDD
410 420 430 440 450
EQGRARSRSP LRNGEEQGSI PLRKVTSQVV DRNKLSNIFN TTAPGDKESA
460 470 480 490 500
ASKGMIAVMT FVIFHSYSIA LTAMMTWALL YHSIFGLILL ILTCILWIFR
510 520 530 540 550
DTRKSSFAMA PIILMYIEFL LILQYFLSMD IHAEIGDPAW MNFVGIEWTT
560 570 580 590 600
LPVHAVIILC VQTLLTLPVF LLLRLARREK FYESLSDYER QRRINSYGTF
610 620 630 640 650
GASKTGAGGV AVAKDPKSRK FAAFVEYLSN KVSVYFIFVV SVVLLVVSTC
660 670 680 690 700
FAPNFYNILF FALWALNLIY LKFSFRLYRG LAYAFWLTLT FYTSIVIIAL
710 720 730 740 750
YIYQFPGVSQ WIIRNTSLSQ EWLNAIGLVD FRAIGESGAL FLQLLAPIAL
760 770 780 790 800
FVVTMLQLKF FHGPWSRATS PRRAENDPPT STTEAAAVAS TSGTQGRAHA
810 820 830 840 850
AGDTLVKKLH KLANQTIELL WRFFEVHISK IVFVIIAIFI ANNINALYIP
860 870 880 890 900
LVILLSLAIC LPSAADGIFS LFMCAYLFLV ALSKMIYQLD IVPELSQIDR
910 920 930 940 950
GVGADNCSHG NISMPEWFGL KKEVEGTEPI YMLFGVIVSI IALAFQSIVI
960 970 980 990 1000
YRQRHYRASL GLPESMRAKV FPDFHHSHFD RSLKNAIQFL IDYGFYKFGL
1010 1020 1030 1040 1050
EITMIAIGID IFNRMDALAA IQCFWLVLFA LNKRVFVRRI WVFYVIYMAI
1060 1070 1080 1090 1100
LYPLQFFSYV GLPPDSCIEY PWSYWIPSYS DDARFNLSYL LNLSIYGVNW
1110 1120 1130 1140 1150
PSAYLIGDFF VLLLASCQLA VFRREGEDND SIYNDGNFVI KPENPQYDFI
1160 1170 1180 1190 1200
DTKKSYVDYF KSFVFHYGHW ITLMSTLAAG IAGTSLFALG YIIFTLTMLW
1210 1220 1230 1240 1250
SGNNLYVMNS TLRSFEHTLK RWNALLGYTL FTITMKVCLQ IFGCVFLSWF
1260 1270 1280 1290 1300
DQSGGWGKTL CIVRQLFSIT CVNNECHVLK ELEDFSKACA VETKEGNIGF
1310 1320 1330 1340 1350
DVIALSFLVF QIRIFHSWYF QHCMVEYRSE VILANRGAVL KNQLIEKEMK
1360 1370 1380 1390 1400
EQNEQQKAKF NDIRRRTEAI RERYQKQIER GAAERDFEPV TYGHAKRAGD
1410 1420 1430 1440 1450
YYMFKYDPEN DDLVEPVDSF VPEVDPKATA YDRLDPGQIM YAATAHDLDL
1460 1470 1480 1490 1500
AKTVQQVKKG DTIKDPDSRA LIAVSEPEAR KPGGTEETDG DEDEDNKDSK
1510 1520 1530 1540 1550
VESTAKFIQK MIASALDLCS VTLNKLCREH RYVGFVLSKE KQKLKSGHSE
1560 1570 1580 1590 1600
SLSNTSRKLT DIRSAVDLPS LQLVQSANDV EKMETAVSVD WQQKSSATRL
1610 1620 1630 1640 1650
LNAVVNCIGA HTDILCYFFA IMTQVMTGGL ITLPLPLMSL FWGNLSNPRP
1660 1670 1680 1690 1700
SKFFWVTMIT YTECVIVIKF VCQFAFMPYN SITWRTEHQM DPMSLDKLFG
1710 1720 1730 1740 1750
VSQRDSFALW DIVLLFSLFF HRYMLRKLGL WKDANLTDTF TLKEEPRSAS
1760 1770 1780 1790 1800
GSDTGSPKKI AQEPKVVVTQ SDTLEGTSGG EIVIPSDPNA VSNMEELDCE
1810 1820 1830 1840 1850
PPIPEKQSGP IGRFIHQLFH PKFRYIRDLY PIMFGIDVIC FLIMTFGYSA
1860 1870 1880 1890 1900
FGEGGSGNVL DDVKASRIPV TLVVMLVGMT LAIIIDRALY LRKSVVGKLI
1910 1920 1930 1940 1950
YQVLMIAFLH IWVFLVLPNM TRRSAISNHV AQALYVIKSC YFLVSAWQIR
1960 1970 1980 1990 2000
NGYPELCIGN LLTHSYGMTN MIAFKVFMNI PFLFELRTAI DWTWTDTSMP
2010 2020 2030 2040 2050
LFDFFNMENF YAHIFNIKCA RQFEAAYPAP RGIPKGKLVK YMMGFPIIIG
2060 2070 2080 2090 2100
VVIFIFSPLL LWSLLNQIGT ISMPEKVTLR ISIEGYPPLY EMEAQGSNHD
2110 2120 2130 2140 2150
NAELGMIKPD QLASLNQALT DSYTTRDTNS ILRSRMSVSY LKGYTYEDIL
2160 2170 2180 2190 2200
IVRFRPESEI YWPISQDSRN AMIDKLSRNT SVNFEVSLEF TRPYDPNENA
2210 2220 2230 2240 2250
ALKHSKSWLV PISLDMTIRA KIQSALRGDP GHPILIPQSI PAFIQVPNQG
2260 2270 2280 2290 2300
ELTLPTSIGN TIINDGNPRI NTTGMEKSDE ARAWFDSLTL NLEQGKSQNE
2310 2320 2330 2340 2350
KMWIATSEHP GDQNAKLWIK TANTTYSGRP YLQVVGFIDR AFPSFLAKVF
2360 2370 2380 2390 2400
KGGVIAVYLS VILVVGRGLV RGIFTTSPST VMFTELPNAD HLLKICLDIY
2410 2420 2430 2440
LVREAKDFML EQDLFAKLIF LFRSPATLIE WTRMSKKKQE
Length:2,440
Mass (Da):276,517
Last modified:September 3, 2014 - v2
Checksum:i37E89B727B3EB010
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A061ACU2A0A061ACU2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,442Annotation score:
C6KRJ3C6KRJ3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,400Annotation score:
Q17897Q17897_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,438Annotation score:
H9G2S2H9G2S2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:
H9G2S3H9G2S3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:
A0A061AJB7A0A061AJB7_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,404Annotation score:
A0A061AE33A0A061AE33_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:
O01260O01260_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,704Annotation score:
B9WRT3B9WRT3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,730Annotation score:
A0A061AL01A0A061AL01_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,686Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CBH29652.2
RefSeqiNP_001255387.2, NM_001268458.2

Genome annotation databases

EnsemblMetazoaiC10C5.1c; C10C5.1c; WBGene00007505
GeneIDi182492

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CBH29652.2
RefSeqiNP_001255387.2, NM_001268458.2

3D structure databases

ProteinModelPortaliD0VWN8
SMRiD0VWN8
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiD0VWN8
PeptideAtlasiD0VWN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC10C5.1c; C10C5.1c; WBGene00007505
GeneIDi182492

Organism-specific databases

CTDi182492
WormBaseiC10C5.1c ; CE49745 ; WBGene00007505 ; pezo-1

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00390000013029
HOGENOMiHOG000022123

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD0VWN8_CAEEL
AccessioniPrimary (citable) accession number: D0VWN8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: September 3, 2014
Last modified: October 10, 2018
This is version 58 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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