UniProtKB - D0UFC7 (PB2_QRFVE)
Polymerase basic protein 2
PB2
Functioni
subunit of the RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.
By similarityGO - Molecular functioni
- RNA binding Source: InterPro
GO - Biological processi
- 7-methylguanosine mRNA capping Source: UniProtKB-KW
- cap snatching Source: UniProtKB-KW
- viral RNA genome replication Source: InterPro
Keywordsi
Biological process | Cap snatching, mRNA capping, mRNA processing |
Names & Taxonomyi
Protein namesi | Recommended name: Polymerase basic protein 2Short name: PB2 |
Gene namesi | Name:PB2 Ordered Locus Names:Segment 2 |
Organismi | Quaranfil virus (isolate QrfV/Tick/Afghanistan/EG_T_377/1968) (QRFV) |
Taxonomic identifieri | 1559362 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Insthoviricetes › Articulavirales › Orthomyxoviridae › Quaranjavirus › |
Virus hosti | Ixodidae (hardbacked ticks) [TaxID: 6939] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000443069 | 1 – 733 | Polymerase basic protein 2Add BLAST | 733 |
Interactioni
Subunit structurei
RNA polymerase is composed of three subunits: PA, PB1 and PB2.
By similarityStructurei
Family & Domainsi
Family and domain databases
InterProi | View protein in InterPro IPR001591, INV_PB2 |
Pfami | View protein in Pfam PF00604, Flu_PB2, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAATPESLQA RKTRLLSVVR KIKSVALDPL ADQVFGLLRS NPVCNKRVLT
60 70 80 90 100
KYARVVKDPD PIATTQLLMG QKYPILAKEK YLHHFTPEER AANFAEEEDC
110 120 130 140 150
RRPGWKRCTR KALNLWLDKE IEPNEETKQV IKVLYENSFD LVRDYLSHSW
160 170 180 190 200
DRAIIRYGIV PKERQVVATR KVLVDVPKEY RQKAVVEIIQ PGFNLNQPEV
210 220 230 240 250
KIYVEKIMEK IGHKMVLGMS IVDQARVLLN SLDPKMRMLP VAVTLHDNLA
260 270 280 290 300
QHSISYYGNN WMVHHLPGRV YDTPGDTNDL REACSLIMRE VLKVKPEKRR
310 320 330 340 350
DHLLHLRKGP QGLLEVLQET KENYPVKVIK SLLGLPCSKS HDYFGTQMII
360 370 380 390 400
EAAVEESRLV TSGGGVSWRE YTGIERIHFR HDDVRGWYTH DGPLIKEIVF
410 420 430 440 450
SRTERKTFTK LLVNIANYIH YDWAARPAKT AKEMRRLTME EVMLSPWSFL
460 470 480 490 500
GATRGIWQEF WARLDSSYFP TSEEIRNYLQ MGDGEIKIRC VLETEVPGDT
510 520 530 540 550
SVYYRVTDEG ALVEVGGSSR IPKIESLPKR SSKTLDGTWN SNDMTFIPIL
560 570 580 590 600
HPTVCLPRTI EFHYSRPDLL SDIQCFNFSN YNQHCPYLLP ANERASFCNT
610 620 630 640 650
ARMMLYGAST QVRRWPKVYL AYLYCFAGFH ETPTVSKLHR TRFLTYDEID
660 670 680 690 700
LYAQRGVFKH NPENDTWLIF NKEWVGLNDP FQFPGLLVSS ALLGYRLENV
710 720 730
THAGKRKRED DLMDLKDGMK ELESKMDGSS VYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ499302 Genomic RNA Translation: ACY56278.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | GQ499302 Genomic RNA Translation: ACY56278.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
InterProi | View protein in InterPro IPR001591, INV_PB2 |
Pfami | View protein in Pfam PF00604, Flu_PB2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PB2_QRFVE | |
Accessioni | D0UFC7Primary (citable) accession number: D0UFC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 31, 2018 |
Last sequence update: | December 15, 2009 | |
Last modified: | February 23, 2022 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |