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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Bacteroides sp. 2_1_33B
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.UniRule annotation

Catalytic activityi

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei167UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2UniRule annotation (EC:2.3.1.179UniRule annotation)
Gene namesi
Name:fabFImported
ORF Names:HMPREF0103_3707Imported
OrganismiBacteroides sp. 2_1_33BImported
Taxonomic identifieri469589 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000004708 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliD0TJJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 421PKS_KSInterPro annotationAdd BLAST416

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili79 – 99Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

OrthoDBiPOG091H018O

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR017568 3-oxoacyl-ACP_synth-2
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PIRSFiPIRSF000447 KAS_II, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR03150 fabF, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

D0TJJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELKRVVVTG LGAITPLGNT LPETWEGIIN GKSGAGPITQ FDASKFKTQF
60 70 80 90 100
ACEVKGFDPL KVMDRKEARK CDRYSLFAID AAKQAIEDAA MDLDKEDKNR
110 120 130 140 150
IGVIFASGIG GIKTFDEEVL SYAKIKDTIG PKFNPFFIPK MISDIAAGHI
160 170 180 190 200
SMLYGFHGPN FATVSACASS TNAISDAFNY IRLGKANVII TGGAEAAVSE
210 220 230 240 250
SGVGGFNSMN ALSTRNDSPE TASRPFSASR DGFVMGEGGA CLVLEEMEHA
260 270 280 290 300
LARGAKIYCE IAGTGMSADA YHLTASHPDG LGAKLVMRNA LEDAGMAPED
310 320 330 340 350
IDYINVHGTS TPVGDISEVK AIKDVFGEHA YQLNISSTKS MTGHLLGAAG
360 370 380 390 400
AVEAILCIMA INDGIIPPTI NHAEGDDDPE IDYKLNFTFN KAQKREVKAA
410 420
LSNTFGFGGH NACAIVKKFV K
Length:421
Mass (Da):44,695
Last modified:December 15, 2009 - v1
Checksum:iACF56C683D02C303
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG705154 Genomic DNA Translation: EEY81577.1
RefSeqiWP_008774316.1, NZ_GG705154.1

Genome annotation databases

EnsemblBacteriaiEEY81577; EEY81577; HMPREF0103_3707
GeneIDi5307976

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG705154 Genomic DNA Translation: EEY81577.1
RefSeqiWP_008774316.1, NZ_GG705154.1

3D structure databases

ProteinModelPortaliD0TJJ1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEEY81577; EEY81577; HMPREF0103_3707
GeneIDi5307976

Phylogenomic databases

OrthoDBiPOG091H018O

Enzyme and pathway databases

UniPathwayi
UPA00094

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR017568 3-oxoacyl-ACP_synth-2
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PIRSFiPIRSF000447 KAS_II, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR03150 fabF, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD0TJJ1_9BACE
AccessioniPrimary (citable) accession number: D0TJJ1
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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