Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Conotoxin im23.3

Gene
N/A
Organism
Conus imperialis (Imperial cone)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Neurotoxin that induces excitatory symptoms in mice following intracranial administration. No symptoms are observed after intraperitoneal and intravenous (tail vein) injections (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionNeurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conotoxin im23.31 Publication
OrganismiConus imperialis (Imperial cone)
Taxonomic identifieri35631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusStephanoconus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000041704523 – 28By similarity6
ChainiPRO_000041712831 – 70Conotoxin im23.3Add BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 41By similarity
Disulfide bondi45 ↔ 53By similarity
Disulfide bondi54 ↔ 69By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

3D structure databases

SMRiD0PX86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is XXIII (C-C-C-CC-C).Curated

Sequence similaritiesi

Belongs to the conotoxin K superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D0PX86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMRMTLTLF VLVVMTAASA SGDALTEAKR IPYCGQTGAE CYSWCKEQHL
60 70
IRCCDFVKYV GMNPPADKCR
Length:70
Mass (Da):7,825
Last modified:December 15, 2009 - v1
Checksum:i78163B4ABF61B09E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ375240 mRNA Translation: ACQ66000.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ375240 mRNA Translation: ACQ66000.1

3D structure databases

SMRiD0PX86
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCAN3_CONIM
AccessioniPrimary (citable) accession number: D0PX86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2012
Last sequence update: December 15, 2009
Last modified: September 12, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again