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Entry version 93 (02 Jun 2021)
Sequence version 1 (15 Dec 2009)
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Protein

ATP-dependent RNA helicase laf-1

Gene

laf-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional ATP-dependent RNA helicase (PubMed:27546789).

Plays a role in RNA remodeling, but is not required for RNA unwinding (PubMed:27546789).

Binds to RNA in a concentration-dependent manner to stimulate annealing between two complementary strands of RNA (PubMed:26015579, PubMed:27546789).

This process is also dependent upon ATP; ATP reduces binding to RNA and subsequently diminishes RNA annealing (PubMed:27546789).

Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in the regulation of transcription and translation initiation. Involved in innate immunity (By similarity).

Involved in both stress and inflammatory responses (By similarity).

Promotes liquid-liquid phase separation of P granules, which is a process important for intracellular organization and stress granule assembly (PubMed:26015579).

Required for embryonic development (PubMed:19361491, PubMed:26015579).

Plays a role in sexual cell fate determination by negatively regulating the translation of the sex determining protein tra-2 (PubMed:9043090, PubMed:9321409, PubMed:26015579).

May play a protective role in the response to heat and oxidative stress (PubMed:24844228).

May negatively regulate extrinsic apoptotic signaling pathway via death domain receptors. May be involved in mitotic chromosome segregation (By similarity).

By similarity6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.3156 mM for ATP1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi275 – 282ATPPROSITE-ProRule annotation8

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATPase activity, acting on RNA Source: UniProtKB
    • ATP binding Source: UniProtKB-KW
    • identical protein binding Source: UniProtKB
    • RNA binding Source: GO_Central
    • RNA helicase activity Source: GO_Central
    • RNA strand annealing activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHelicase, Hydrolase, RNA-binding
    Biological processTranscription, Transcription regulation, Translation regulation
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-CEL-6798695, Neutrophil degranulation

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    ATP-dependent RNA helicase laf-1Curated (EC:3.6.4.131 Publication)
    Alternative name(s):
    DEAD-box RNA helicase laf-11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:laf-11 PublicationImported
    ORF Names:Y71H2AM.19Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

    Organism-specific databases

    WormBase

    More...
    WormBasei
    Y71H2AM.19a ; CE38657 ; WBGene00002244 ; laf-1
    Y71H2AM.19b ; CE47305 ; WBGene00002244 ; laf-1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Inflammasome, Membrane, Nucleus

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Embryonic lethal or lethal at the first larval stage of development (PubMed:9043090). Embryos exhibit severe morphological defects (PubMed:9043090). RNAi-mediated knockdown results in embryonic lethality in 88% of animals (PubMed:19361491, PubMed:26015579). Knockdown also results in disrupted P granule organization and assembly in the early embryo (PubMed:26015579). Reduced survival in response to heat and oxidative stress (PubMed:24844228). Double RNAi knockdown with vbh-1 results in a high number of female offspring (PubMed:19361491).4 Publications

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi426R → C in q80; embryonic lethal. 1 Publication1
    Mutagenesisi430M → I in q217; embryonic lethal. 1 Publication1
    Mutagenesisi434T → I in q267; embryonic lethal. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004385221 – 708ATP-dependent RNA helicase laf-1CuratedAdd BLAST708

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    D0PV95

    PeptideAtlas

    More...
    PeptideAtlasi
    D0PV95

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in the germline and soma of young adult hermaphrodites.1 Publication

    <p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expressed at all developmental stages. Highly expressed in embryos with levels decreasing during larval development and increasing as animals reach adulthood.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    WBGene00002244, Expressed in material anatomical entity and 4 other tissues

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Binds RNA as a monomer at low laf-1 concentrations and as a dimer at high laf-1 concentrations.

    1 Publication

    GO - Molecular functioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    6239.Y71H2AM.19b

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    D0PV95

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini262 – 453Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST192
    Domaini465 – 626Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 191DisorderedSequence analysisAdd BLAST191
    Regioni623 – 708DisorderedSequence analysisAdd BLAST86

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi231 – 259Q motifPROSITE-ProRule annotationAdd BLAST29
    Motifi397 – 400DEAD boxPROSITE-ProRule annotation4

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi72 – 98Basic and acidic residuesSequence analysisAdd BLAST27
    Compositional biasi128 – 143Polar residuesSequence analysisAdd BLAST16
    Compositional biasi144 – 167Basic and acidic residuesSequence analysisAdd BLAST24
    Compositional biasi168 – 182Polar residuesSequence analysisAdd BLAST15
    Compositional biasi688 – 708Polar residuesSequence analysisAdd BLAST21

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal domain is required for the multimeric binding of laf-1 to RNA.2 Publications

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0335, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000168275

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    D0PV95

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GPDWWGQ

    Database of Orthologous Groups

    More...
    OrthoDBi
    595675at2759

    Family and domain databases

    Database of protein disorder

    More...
    DisProti
    DP01113

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011545, DEAD/DEAH_box_helicase_dom
    IPR014001, Helicase_ATP-bd
    IPR001650, Helicase_C
    IPR027417, P-loop_NTPase
    IPR000629, RNA-helicase_DEAD-box_CS
    IPR014014, RNA_helicase_DEAD_Q_motif

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00270, DEAD, 1 hit
    PF00271, Helicase_C, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00487, DEXDc, 1 hit
    SM00490, HELICc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540, SSF52540, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00039, DEAD_ATP_HELICASE, 1 hit
    PS51192, HELICASE_ATP_BIND_1, 1 hit
    PS51194, HELICASE_CTER, 1 hit
    PS51195, Q_MOTIF, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform bImported (identifier: D0PV95-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MESNQSNNGG SGNAALNRGG RYVPPHLRGG DGGAAAAASA GGDDRRGGAG
    60 70 80 90 100
    GGGYRRGGGN SGGGGGGGYD RGYNDNRDDR DNRGGSGGYG RDRNYEDRGY
    110 120 130 140 150
    NGGGGGGGNR GYNNNRGGGG GGYNRQDRGD GGSSNFSRGG YNNRDEGSDN
    160 170 180 190 200
    RGSGRSYNND RRDNGGDGQN TRWNNLDAPP SRGTSKWENR GARDERIEQE
    210 220 230 240 250
    LFSGQLSGIN FDKYEEIPVE ATGDDVPQPI SLFSDLSLHE WIEENIKTAG
    260 270 280 290 300
    YDRPTPVQKY SIPALQGGRD LMSCAQTGSG KTAAFLVPLV NAILQDGPDA
    310 320 330 340 350
    VHRSVTSSGG RKKQYPSALV LSPTRELSLQ IFNESRKFAY RTPITSALLY
    360 370 380 390 400
    GGRENYKDQI HKLRLGCHIL IATPGRLIDV MDQGLIGMEG CRYLVLDEAD
    410 420 430 440 450
    RMLDMGFEPQ IRQIVECNRM PSKEERITAM FSATFPKEIQ LLAQDFLKEN
    460 470 480 490 500
    YVFLAVGRVG STSENIMQKI VWVEEDEKRS YLMDLLDATG DSSLTLVFVE
    510 520 530 540 550
    TKRGASDLAY YLNRQNYEVV TIHGDLKQFE REKHLDLFRT GTAPILVATA
    560 570 580 590 600
    VAARGLDIPN VKHVINYDLP SDVDEYVHRI GRTGRVGNVG LATSFFNDKN
    610 620 630 640 650
    RNIARELMDL IVEANQELPD WLEGMSGDMR SGGGYRGRGG RGNGQRFGGR
    660 670 680 690 700
    DHRYQGGSGN GGGGNGGGGG FGGGGQRSGG GGGFQSGGGG GRQQQQQQRA

    QPQQDWWS
    Length:708
    Mass (Da):76,343
    Last modified:December 15, 2009 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13644AD830B03888
    GO
    Isoform aImported (identifier: D0PV95-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-105: Missing.

    Show »
    Length:643
    Mass (Da):69,896
    Checksum:iA19EC45F090BB19B
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05867241 – 105Missing in isoform a. CuratedAdd BLAST65

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    FJ348231 mRNA Translation: ACO56244.1
    BX284603 Genomic DNA Translation: CCD73871.1
    BX284603 Genomic DNA Translation: CCG28150.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001254858.1, NM_001267929.1
    NP_001254859.1, NM_001267930.1 [D0PV95-1]

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    Y71H2AM.19a.1; Y71H2AM.19a.1; WBGene00002244 [D0PV95-2]
    Y71H2AM.19b.1; Y71H2AM.19b.1; WBGene00002244 [D0PV95-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    190611

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    cel:CELE_Y71H2AM.19

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    FJ348231 mRNA Translation: ACO56244.1
    BX284603 Genomic DNA Translation: CCD73871.1
    BX284603 Genomic DNA Translation: CCG28150.1
    RefSeqiNP_001254858.1, NM_001267929.1
    NP_001254859.1, NM_001267930.1 [D0PV95-1]

    3D structure databases

    SMRiD0PV95
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi6239.Y71H2AM.19b

    Proteomic databases

    EPDiD0PV95
    PeptideAtlasiD0PV95

    Genome annotation databases

    EnsemblMetazoaiY71H2AM.19a.1; Y71H2AM.19a.1; WBGene00002244 [D0PV95-2]
    Y71H2AM.19b.1; Y71H2AM.19b.1; WBGene00002244 [D0PV95-1]
    GeneIDi190611
    KEGGicel:CELE_Y71H2AM.19

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    190611
    WormBaseiY71H2AM.19a ; CE38657 ; WBGene00002244 ; laf-1
    Y71H2AM.19b ; CE47305 ; WBGene00002244 ; laf-1

    Phylogenomic databases

    eggNOGiKOG0335, Eukaryota
    GeneTreeiENSGT00940000168275
    InParanoidiD0PV95
    OMAiGPDWWGQ
    OrthoDBi595675at2759

    Enzyme and pathway databases

    ReactomeiR-CEL-6798695, Neutrophil degranulation

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:D0PV95

    Gene expression databases

    BgeeiWBGene00002244, Expressed in material anatomical entity and 4 other tissues

    Family and domain databases

    DisProtiDP01113
    InterProiView protein in InterPro
    IPR011545, DEAD/DEAH_box_helicase_dom
    IPR014001, Helicase_ATP-bd
    IPR001650, Helicase_C
    IPR027417, P-loop_NTPase
    IPR000629, RNA-helicase_DEAD-box_CS
    IPR014014, RNA_helicase_DEAD_Q_motif
    PfamiView protein in Pfam
    PF00270, DEAD, 1 hit
    PF00271, Helicase_C, 1 hit
    SMARTiView protein in SMART
    SM00487, DEXDc, 1 hit
    SM00490, HELICc, 1 hit
    SUPFAMiSSF52540, SSF52540, 1 hit
    PROSITEiView protein in PROSITE
    PS00039, DEAD_ATP_HELICASE, 1 hit
    PS51192, HELICASE_ATP_BIND_1, 1 hit
    PS51194, HELICASE_CTER, 1 hit
    PS51195, Q_MOTIF, 1 hit

    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDDX3_CAEEL
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D0PV95
    Secondary accession number(s): Q4W5R4
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
    Last sequence update: December 15, 2009
    Last modified: June 2, 2021
    This is version 93 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. SIMILARITY comments
      Index of protein domains and families
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