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Entry version 28 (22 Apr 2020)
Sequence version 1 (15 Dec 2009)
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Protein

RxLR effector protein PSR2

Gene

PSR2

Organism
Phytophthora infestans (strain T30-4) (Potato late blight fungus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Secreted effector that possesses RNA silencing suppression activity by inhibiting the biogenesis of small RNAs in the host plant to promote enhanced susceptibility of host to the pathogen during infection (PubMed:25387135, PubMed:27503598). Interferes with secondary siRNA production by associating with host dsRNA-binding protein DRB4 (By similarity). Inhibits the host salicylic acid pathway during infection (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RxLR effector protein PSR21 Publication
Alternative name(s):
Suppressor of RNA silencing protein 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSR21 Publication
ORF Names:PITG_15152
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhytophthora infestans (strain T30-4) (Potato late blight fungus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri403677 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarStramenopilesOomycetesPeronosporalesPeronosporaceaePhytophthora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006643 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Partially assembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:PITG_15152

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500301232522 – 760RxLR effector protein PSR2Add BLAST739

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

The expression is highest in the biotrophic phase of the pathogen.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host dsRNA-binding protein DRB4.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4787.PITG_15152T0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
D0NRS4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 134WY1By similarityAdd BLAST48
Repeati135 – 221LWY2By similarityAdd BLAST87
Repeati222 – 312LWY3By similarityAdd BLAST91
Repeati313 – 403LWY4By similarityAdd BLAST91
Repeati404 – 496LWY5By similarityAdd BLAST93
Repeati497 – 584LWY6By similarityAdd BLAST88
Repeati585 – 760LWY7By similarityAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni87 – 7607 X 93 AA tandem repeatsBy similarityAdd BLAST674

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi47 – 62RxLR-dEER1 PublicationAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate.1 Publication
The C-terminal region (residues 87 to 760) consists of seven imperfect tandem repeats, including one W-Y motif (WY1) and six L-W-Y motifs (LWY2 to LWY7) (By similarity). WY1 forms a 3 alpha-helix fold with one hydrophobic core and each L-W-Y motif forms a highly conserved fold consisting of 5 alpha-helices (By similarity). The units contribute differently to the virulence since WY1, LWY2 and LWY6 are important for the ability to suppress the biogenesis of small RNA in host and virulence activity of the pathogen, whereas LWY3, LWY4, LWY5 and LWY7 are dispensable for PSR2 function (By similarity). WY1 and LWY2 are sufficient for association with DRB4, suppress gene silencing and promote infection (By similarity). These units may function as basic building blocks of Phytophthora effectors to enable virulence activity and accelerate the evolution of novel functions (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RxLR effector family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021192_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
D0NRS4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLYMKTD

Database of Orthologous Groups

More...
OrthoDBi
717762at2759

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

D0NRS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCRYAVLAL AVAYFAGSIA ANDSQIVAVK GPASIRFTPA IHVVRGRFLR
60 70 80 90 100
AANTADERNE DRGINLKSMP GFEKIASLFT KKNTPGPLLS WFEKKKSPDY
110 120 130 140 150
VFLKLKINKG KQQLFDHPDW NVWVQYTTSV VKSDPEEAMI AALRTHYTDD
160 170 180 190 200
ILSKLLESAK NVPKTSGLAT KMQMEHWVAS KTPSQMFQFL RLDKVRNGVL
210 220 230 240 250
DDPTLSIWIN YMKLYNSKPV NKKQQVTLVS MLTTHYKDRG VLDIIEAAKK
260 270 280 290 300
VPKTAPAARQ LEMEQIQFWL KNGKSPDELL TVLSLDKAGN QLLASPRFKF
310 320 330 340 350
WSKYVDNYNR DFPDEATTVM ATLRNQLGDE DITPILIAAG KVPSTEKAAA
360 370 380 390 400
KLQAEQFKSW LRENEDPAKV FQLLKLDNSA DDLLGSPQFK LWGKYVEDLN
410 420 430 440 450
LKPEHNDLQV SIITILRKNY GDDVLGNMVL AGKKAPSTSF MARRLEDELY
460 470 480 490 500
KGWIAAGSSP DGVFKHLKFD KAGENVIQSP LWGLYTKFLE HYYKSFPTPM
510 520 530 540 550
MSALAKGYDG DALAKLLIAA EKIPTSNTLA TKLQTGQIQR WLDDKDQPGK
560 570 580 590 600
IFKALLLDDM ADDILTSPLF NTWTRYLDEF NKKFPDEKVS MTDTFRTSLD
610 620 630 640 650
DETLKSLLIT AKELPDMKTL STKLQTVQIE RWLASKTSPE DAFAVLALNK
660 670 680 690 700
AGGNVLSKPL LNTWAAYLES FNAKFPRSRV SMIDTFREFF GDKALLTTLA
710 720 730 740 750
AAKEVESTKK VATSLQDSLL SKWVLAKKPP SGVAKLVGTD EAGAKLLKTY
760
TTKYMERYGQ
Length:760
Mass (Da):85,357
Last modified:December 15, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF18FB76860CCD04
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS028155 Genomic DNA Translation: EEY63424.1

NCBI Reference Sequences

More...
RefSeqi
XP_002898309.1, XM_002898263.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
PITG_15152T0; PITG_15152T0; PITG_15152

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9476029

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pif:PITG_15152

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS028155 Genomic DNA Translation: EEY63424.1
RefSeqiXP_002898309.1, XM_002898263.1

3D structure databases

SMRiD0NRS4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4787.PITG_15152T0

Genome annotation databases

EnsemblProtistsiPITG_15152T0; PITG_15152T0; PITG_15152
GeneIDi9476029
KEGGipif:PITG_15152

Organism-specific databases

EuPathDBiFungiDB:PITG_15152

Phylogenomic databases

HOGENOMiCLU_021192_3_0_1
InParanoidiD0NRS4
OMAiTLYMKTD
OrthoDBi717762at2759

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSR2_PHYIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D0NRS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2019
Last sequence update: December 15, 2009
Last modified: April 22, 2020
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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