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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Sulfolobus solfataricus (strain 98/2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41NADUniRule annotation1
Binding sitei68NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei132NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi162Iron; shared with adjacent protomerUniRule annotation1
Metal bindingi177IronUniRule annotation1
Binding sitei227NAD; via amide nitrogenUniRule annotation1
Binding sitei237GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi60 – 61NADUniRule annotation2
Nucleotide bindingi160 – 162NAD; shared with adjacent protomerUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
Ordered Locus Names:Ssol_1411Imported
OrganismiSulfolobus solfataricus (strain 98/2)Imported
Taxonomic identifieri555311 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001493 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD0KSC6
SMRiD0KSC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000106048
KOiK22699
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

D0KSC6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKIKQVDE VKISRYIIKE TMEDWYQFVE SDVVIVGAGP SGLSAAYYLA
60 70 80 90 100
KAGLKTLVFE RRLSFGGGIG GGAMLFHKLI IEKPADEILR EVNIRLKEVE
110 120 130 140 150
EGVYVVDSAE FMAKLATAAI DAGAKIIHGV TVDDVIFREN PLRVAGVAVE
160 170 180 190 200
WTATQMASLH VDPIFISAKA VVDATGHDAE VISVAARKIP ELGIVIPGEK
210 220 230 240 250
SAYSERAEEL TVINTGKVAE GLYATGMAVT EVKGLPRMGP IFGAMVLSGK
260
AVAGEITKDL LKSEIRA
Length:267
Mass (Da):28,630
Last modified:December 15, 2009 - v1
Checksum:i47603B956AF76DA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001800 Genomic DNA Translation: ACX91645.1
RefSeqiWP_009988737.1, NZ_ACUK01000025.1

Genome annotation databases

EnsemblBacteriaiACX91645; ACX91645; Ssol_1411
GeneIDi27426731
KEGGisol:Ssol_1411

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001800 Genomic DNA Translation: ACX91645.1
RefSeqiWP_009988737.1, NZ_ACUK01000025.1

3D structure databases

ProteinModelPortaliD0KSC6
SMRiD0KSC6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX91645; ACX91645; Ssol_1411
GeneIDi27426731
KEGGisol:Ssol_1411

Phylogenomic databases

HOGENOMiHOG000106048
KOiK22699
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Enzyme and pathway databases

UniPathwayi
UPA00060

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD0KSC6_SULS9
AccessioniPrimary (citable) accession number: D0KSC6
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: July 18, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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