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Protein

Alanine racemase

Gene

HPKB_0909

Organism
Helicobacter pylori (strain 52)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (HPKB_0909)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei135SubstrateUniRule annotation1
Active sitei271Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei319Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL684950:G1GFG-943-MONOMER
UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:HPKB_0909Imported
OrganismiHelicobacter pylori (strain 52)Imported
Taxonomic identifieri684950 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000002568 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliD0K072
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 377Ala_racemase_CInterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

D0K072-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKRASFVEV NSASLRHNFS TVKSIVPKDA HIMAVVKANA YGAGAIKASE
60 70 80 90 100
IFLQEGANYL GVATLDEALE LRSHFSKTPI LILGYSPNSN ASMLIDNDLS
110 120 130 140 150
AMIFSLEQAE VFSQMALKSQ KRLKIHLKID TGMHRLGLEP NFKSIEIIKK
160 170 180 190 200
ICALKGLEIE GIFTHLSNAD AKIKTHAKNQ MKAFNAFLEQ LLDQKIEFQY
210 220 230 240 250
RHAYNSAGIL SLCNGNENRL LNLYRPGIML YGFYPSNGMK ETCPTILKNV
260 270 280 290 300
ISLKAQIVQI RSVKKGEFIG YGEHFYTNEE TLVGVLALGY ADGLMRTLGN
310 320 330 340 350
RIQVAINNQL APLIGKVCMD QCFVKLNNIE AKEGDEVILF GDKSTKANDA
360 370
SEIAALLNTI PYETISTLSK RLERVYI
Length:377
Mass (Da):41,856
Last modified:December 15, 2009 - v1
Checksum:i53382F14DF9871AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001680 Genomic DNA Translation: ACX99492.1
RefSeqiWP_000917946.1, NC_017354.1

Genome annotation databases

EnsemblBacteriaiACX99492; ACX99492; HPKB_0909
KEGGihpz:HPKB_0909
PATRICifig|684950.4.peg.965

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001680 Genomic DNA Translation: ACX99492.1
RefSeqiWP_000917946.1, NC_017354.1

3D structure databases

ProteinModelPortaliD0K072
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX99492; ACX99492; HPKB_0909
KEGGihpz:HPKB_0909
PATRICifig|684950.4.peg.965

Phylogenomic databases

HOGENOMiHOG000031444
KOiK01775
OMAiWEILCGF

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

BioCyciHPYL684950:G1GFG-943-MONOMER

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiD0K072_HELP5
AccessioniPrimary (citable) accession number: D0K072
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: October 10, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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