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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Comamonas testosteroni (strain CNB-2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotationSAAS annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotationSAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processCell cycle, Cell divisionUniRule annotationSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotationSAAS annotation (EC:2.4.1.227UniRule annotationSAAS annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:CtCNB1_4114Imported
OrganismiComamonas testosteroni (strain CNB-2)Imported
Taxonomic identifieri688245 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeComamonas
Proteomesi
  • UP000002360 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Interactioni

Protein-protein interaction databases

STRINGi688245.CtCNB1_4114

Structurei

3D structure databases

ProteinModelPortaliD0J7C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 151Glyco_transf_28InterPro annotationAdd BLAST138
Domaini190 – 347Glyco_tran_28_CInterPro annotationAdd BLAST158

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

D0J7C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLIKPNKP RTALVMAGGT GGHIFPGLAV AQELRARGWN VHWLGAPGSM
60 70 80 90 100
ESRIVPAQGF ALELIEFGGV RGKGLKTLVQ LPFRLAKAFS QARAVMKRVQ
110 120 130 140 150
PDVVIGLGGY LTVPGGLMAA ASGVPVVLHE QNSVAGMANK VVAKVAKRVF
160 170 180 190 200
TAFPKVFAKG EWVGNPLRQA FLEQAEPAQR FAGRSGPLKL LVVGGSLGAR
210 220 230 240 250
ALNEIVPQAL ALMPADQRPV VLHQSGTAQI DALRANYQAA GVQAELTPFI
260 270 280 290 300
DDTAKAFADA DLVVCRAGAS TVTEIAAVGA AAVYVPFPAA VDDHQTSNAR
310 320 330 340 350
FLVDAGGGWL QPQSTLSAQG LAEMLQNMQR ATLLERAELA KKMQKTDATA
360
KVVAACEELA A
Length:361
Mass (Da):37,822
Last modified:December 15, 2009 - v1
Checksum:i2C3964D4400213EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001220 Genomic DNA Translation: ACY34860.1
RefSeqiWP_012839828.1, NC_013446.2

Genome annotation databases

EnsemblBacteriaiACY34860; ACY34860; CtCNB1_4114
KEGGictt:CtCNB1_4114
PATRICifig|688245.4.peg.4339

Similar proteinsi

Entry informationi

Entry nameiD0J7C8_COMT2
AccessioniPrimary (citable) accession number: D0J7C8
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: September 27, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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