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Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Helicobacter pylori (strain 51)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processLipopolysaccharide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciHPYL290847:G1G3X-255-MONOMER
UniPathwayiUPA00030
UPA00358; UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotationImported
Ordered Locus Names:KHP_0229Imported
OrganismiHelicobacter pylori (strain 51)Imported
Taxonomic identifieri290847 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
Proteomesi
  • UP000002224 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD0IRA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000007602
KOiK00979
OMAiNSGTERC
OrthoDBiPOG091H00UN

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

D0IRA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIIPARLKS SRFENKVLED IFGLPMVVRC AKNANLVDEC VVACDDESIM
60 70 80 90 100
QTCQRFHIKA VLTSKHHNSG TERCLEAAQI LGLKNNERVL NLQGDEPFLE
110 120 130 140 150
KEVILALLEA TKNAPFMATC AKAIDEEQAK SPNLVKVVLD SQNNALYFSR
160 170 180 190 200
SLIPFLRDAG AKRQTPLLGH IGIYGFHNKE ILEELCALKP CVLEELEKLE
210 220 230 240
QLRALYYQKK IAVKIVQSES VGIDTKEDLQ NALKIFSPNL L
Length:241
Mass (Da):27,032
Last modified:December 15, 2009 - v1
Checksum:i09C84CE46F440A15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000012 Genomic DNA Translation: ACX97443.1
RefSeqiWP_000584078.1, NC_017382.1

Genome annotation databases

EnsemblBacteriaiACX97443; ACX97443; KHP_0229
KEGGihpd:KHP_0229
PATRICifig|290847.5.peg.259

Similar proteinsi

Entry informationi

Entry nameiD0IRA0_HELP1
AccessioniPrimary (citable) accession number: D0IRA0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: February 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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