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Protein

Estrogen receptor

Gene

Esr1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi187 – 262Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandLipid-binding, Metal-binding, Steroid-bindingUniRule annotation, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1251985 Nuclear signaling by ERBB4
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-5689896 Ovarian tumor domain proteases
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-RNO-8931987 RUNX1 regulates estrogen receptor mediated transcription
R-RNO-8939211 ESR-mediated signaling
R-RNO-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptorUniRule annotation
Short name:
ERUniRule annotation
Alternative name(s):
ER-alphaUniRule annotation
Estradiol receptorUniRule annotation
Nuclear receptor subfamily 3 group A member 1UniRule annotation
Gene namesi
Name:Esr1Imported
ORF Names:rCG_41136Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2581 Esr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000019358

Interactioni

Subunit structurei

Binds DNA as a homodimer.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 262Nuclear receptorInterPro annotationAdd BLAST76
Domaini316 – 552NR LBDInterPro annotationAdd BLAST237

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.UniRule annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
TreeFamiTF323751

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR024736 Oestrogen-typ_rcpt_final_C_dom
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12743 ESR1_C, 1 hit
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00543 OESTROGENR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

D0FYH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPMERALG EVYVDNSKPA
60 70 80 90 100
VFNYPEGAAY EFNAAAAAAA AGASAPVYGQ SSITYGPGSE AAAFGANSLG
110 120 130 140 150
AFPQLNSVSP SPLMLLHPPP QLSPFLHPHG HQVPYYLENE PSAYAVRDTG
160 170 180 190 200
PPAFYRSNSD NRRQNGRERL SSSSEKGNMI MESAKETRYC AVCNDYASGY
210 220 230 240 250
HYGVWSCEGC KAFFKRSIQG HNDYMCPATN QCTIDKNRRK SCQACRLRKC
260 270 280 290 300
YEVGMMKGGI RKDRRGGRML KHKRQRDDLE GRNEMGTSGD MRAANLWPSP
310 320 330 340 350
LVIKHTKKNS PALSLTADQM VSALLDAEPP LIYSEYDPSR PFSEASMMGL
360 370 380 390 400
LTNLADRELV HMINWAKRVP GFGDLNLHDQ VHLLECAWLE ILMIGLVWRS
410 420 430 440 450
MEHPGKLLFA PNLLLDRNQG KCVEGMVEIF DMLLATSSRF RMMNLQGEEF
460 470 480 490 500
VCLKSIILLN SGVYTFLSST LKSLEEKDHI HRVLDKITDT LIHLMAKAGL
510 520 530 540 550
TLQQQHRRLA QLLLILSHIR HMSNKGMEHL YNMKCKNVVP LYDLLLEMLD
560 570 580 590 600
AHRLHAPASR MGVPPEEPSQ SQLTTTSSTS AHSLQTYYIP PEAEGFPNTI
Length:600
Mass (Da):67,022
Last modified:December 15, 2009 - v1
Checksum:i87617C9974CB1177
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07001375 Genomic DNA No translation available.
AABR07001376 Genomic DNA No translation available.
AABR07001377 Genomic DNA No translation available.
AABR07001378 Genomic DNA No translation available.
AABR07001379 Genomic DNA No translation available.
AABR07001380 Genomic DNA No translation available.
AABR07001381 Genomic DNA No translation available.
AABR07001382 Genomic DNA No translation available.
AB477039 mRNA Translation: BAI48013.1
CH474052 Genomic DNA Translation: EDL92853.1
CH474052 Genomic DNA Translation: EDL92854.1
CH474052 Genomic DNA Translation: EDL92855.1
CH474052 Genomic DNA Translation: EDL92857.1
CH474052 Genomic DNA Translation: EDL92858.1
RefSeqiXP_006227894.1, XM_006227832.3
XP_008756926.1, XM_008758704.2
XP_017444284.1, XM_017588795.1
UniGeneiRn.10595
Rn.231229

Genome annotation databases

EnsembliENSRNOT00000026350; ENSRNOP00000026350; ENSRNOG00000019358
ENSRNOT00000081017; ENSRNOP00000072170; ENSRNOG00000019358
GeneIDi24890

Similar proteinsi

Entry informationi

Entry nameiD0FYH4_RAT
AccessioniPrimary (citable) accession number: D0FYH4
Secondary accession number(s): F1M839
Entry historyiIntegrated into UniProtKB/TrEMBL: December 15, 2009
Last sequence update: December 15, 2009
Last modified: July 18, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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