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Entry version 72 (16 Oct 2019)
Sequence version 1 (24 Nov 2009)
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Protein
Submitted name:

Low density lipoprotein-related protein 6

Gene

lrp5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Low density lipoprotein-related protein 6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lrp5Imported
Synonyms:LRP6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050518-2 lrp5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1203 – 1223HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1097 ↔ 1112PROSITE-ProRule annotation
Disulfide bondi1115 ↔ 1127PROSITE-ProRule annotation
Disulfide bondi1122 ↔ 1140PROSITE-ProRule annotation
Disulfide bondi1134 ↔ 1149PROSITE-ProRule annotation
Disulfide bondi1153 ↔ 1165PROSITE-ProRule annotation
Disulfide bondi1160 ↔ 1178PROSITE-ProRule annotation
Disulfide bondi1172 ↔ 1187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation, LipoproteinImported

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 26LDL-receptor class BPROSITE-ProRule annotationAdd BLAST26
Repeati27 – 69LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati70 – 110LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 157EGF-likeInterPro annotationAdd BLAST40
Repeati205 – 247LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati248 – 290LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati291 – 334LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati335 – 377LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati378 – 417LDL-receptor class BPROSITE-ProRule annotationAdd BLAST40
Domaini424 – 461EGF-likeInterPro annotationAdd BLAST38
Repeati507 – 549LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati550 – 592LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati593 – 635LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati636 – 672LDL-receptor class BPROSITE-ProRule annotationAdd BLAST37
Repeati676 – 718LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini725 – 762EGF-likeInterPro annotationAdd BLAST38
Repeati808 – 852LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati853 – 895LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati896 – 940LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati941 – 983LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati984 – 1024LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini1033 – 1077EGF-likeInterPro annotationAdd BLAST45
Domaini1114 – 1150EGF-likeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni822 – 845DisorderedSequence analysisAdd BLAST24
Regioni1288 – 1321DisorderedSequence analysisAdd BLAST34
Regioni1380 – 1430DisorderedSequence analysisAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi824 – 841PolarSequence analysisAdd BLAST18
Compositional biasi1288 – 1309PolarSequence analysisAdd BLAST22
Compositional biasi1397 – 1411PolarSequence analysisAdd BLAST15
Compositional biasi1416 – 1430Pro-richSequence analysisAdd BLAST15

Keywords - Domaini

EGF-like domainSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IPT4 Eukaryota
ENOG410XSY5 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230697

KEGG Orthology (KO)

More...
KOi
K03068

Database of Orthologous Groups

More...
OrthoDBi
121310at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
D0EWS1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 3 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 4 hits
4.10.400.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000742 EGF-like_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057 Ldl_recept_a, 3 hits
PF00058 Ldl_recept_b, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 5 hits
SM00192 LDLa, 3 hits
SM00135 LY, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57424 SSF57424, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 3 hits
PS51120 LDLRB, 18 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

D0EWS1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGSNRQIIV QKQIYWPNGL TIDLDEQKLY WADAKLSFIH RANLDGTSRE
60 70 80 90 100
AVVEGSLTHP FALTLYDETL YWTDWQTRSI HACNKHSGEK HREILNGIYS
110 120 130 140 150
PMDIQVLGQE RQPNIQTPCS ERNGGCSHLC LLSPIPPFYS CACPTGVKLK
160 170 180 190 200
EDGKTCRPGA EQVLLLARRT DLRRISLDLP DFTDIVLQVN DIRHAIAIDY
210 220 230 240 250
DPVEGYVYWT DDELRAIRRA RIDGSDAQTL ITNEINHPDG IAVDWVARNL
260 270 280 290 300
YWTDTGTDRI EVTRLNGTSR RVLISENLDE PRAIVLDPIN GYMYWTDWGE
310 320 330 340 350
LPKIERANLD GTDRVVLLNT SLGWPNGLAI DYIAGKLYWG DAKTDKIEVI
360 370 380 390 400
NVDGTNRMTI LEDKLPHIFG FTLLGEYIYW TDWQRRSIER VHIANSTREV
410 420 430 440 450
IVEQLPDLMG LKATKVMEAE GTNGCAENNG GCSHLCFHRP QGLSCACPMG
460 470 480 490 500
LELLSDLRTC VVPEAFLLFT NRADIRSISL GTNSNDVPIP LTGVKEASAL
510 520 530 540 550
DFDVLENRIY WTDVSTKTIS RAFMNGSSVE PVIEFGLDYP EGMAVDWMGR
560 570 580 590 600
NLYWADTGTN RIEVARLDGQ YRQVLVCKDL DNPRSLALDP ANGYMYWTEW
610 620 630 640 650
GGRPRIARAH MDGSNIVTLV DKVGRANGLT IDYIDQRLYW TDLDTCMIES
660 670 680 690 700
TNMQSLQREI VADDLPHPFG LTQYRDYIYW TDWNLRSIER ADKRSGLNRT
710 720 730 740 750
VVQGHLEYVM DILVFHSSRQ DGANDCSQNN GQCAHLCLAS PSGAQCRCAS
760 770 780 790 800
HYTLEANGRN CSSPSSFLLF SQKSSISRMV LGEQSPDMIL PIHVMKNLRA
810 820 830 840 850
ISFDPLERLV YWVDGRQNIR RSRDDGTQAS TVMTPNSDHP KQPHDLSLDP
860 870 880 890 900
YSRTVYWTCE TTNTINIHRM DGHVIGEVLK DDVDKPRAIV VNAEKGYMYF
910 920 930 940 950
TTVQERSAKI EGASLDGTER ESLFTTSLIR PVALALDNKL GKLFWVDADL
960 970 980 990 1000
KRIESSDLSG ANRIVLQDSN ILQPVGLTVL GDHLYWIDKQ QQMIERVDKL
1010 1020 1030 1040 1050
TGEKRTRIQG RLQYLTGIHA VQYMETDEFA THPCSRDNGG CSHICIAKGD
1060 1070 1080 1090 1100
GTPRCSCPMH LVLLQNLLSC GEPPTCSSEQ FTCATGEIDC IPMAWRCDGI
1110 1120 1130 1140 1150
AECADNSDEM NCPICSKLQF QCDKGQCVDI QVRCNGEPDC ADGSDEQDCE
1160 1170 1180 1190 1200
TICLSNQFRC GNSQCILKKQ QCDSFPDCTD ESDERFCDFP PPPNDLPRHT
1210 1220 1230 1240 1250
STIGPVIGII LSVFVMGGMC FVCQRVVCRH YKGPNGGFPH EYISGTPHVP
1260 1270 1280 1290 1300
LNFIAPTNSQ HGKGISCGKS MMSSVSLMGS SSSGAPLYDR NHVTGASSSS
1310 1320 1330 1340 1350
SSSTKGAFYP QMLNPPPSPA TDRSLYNAEV FYSSNSPSTT RSYRPYLMRG
1360 1370 1380 1390 1400
VAPPTTPCST DVCDSDYTTS RWKSNKYYMD LNSDSDPYPP PPTPRSQYMS
1410 1420 1430
AEESCPPSPS TERSYFHLCP PPPSPCTDSS
Length:1,430
Mass (Da):160,013
Last modified:November 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD1FF5E16991B700
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GQ903573 mRNA Translation: ACX46988.1

NCBI Reference Sequences

More...
RefSeqi
NP_001170929.1, NM_001177458.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
568518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:568518

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ903573 mRNA Translation: ACX46988.1
RefSeqiNP_001170929.1, NM_001177458.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi568518
KEGGidre:568518

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4041
ZFINiZDB-GENE-050518-2 lrp5

Phylogenomic databases

eggNOGiENOG410IPT4 Eukaryota
ENOG410XSY5 LUCA
HOGENOMiHOG000230697
KOiK03068
OrthoDBi121310at2759
PhylomeDBiD0EWS1

Family and domain databases

CDDicd00112 LDLa, 3 hits
Gene3Di2.120.10.30, 4 hits
4.10.400.10, 3 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR000742 EGF-like_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 3 hits
PF00058 Ldl_recept_b, 9 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00192 LDLa, 3 hits
SM00135 LY, 17 hits
SUPFAMiSSF57424 SSF57424, 3 hits
PROSITEiView protein in PROSITE
PS01209 LDLRA_1, 2 hits
PS50068 LDLRA_2, 3 hits
PS51120 LDLRB, 18 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiD0EWS1_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: D0EWS1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: October 16, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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