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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotationSAAS annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotationSAAS annotation

Pathwayi: LPS lipid A biosynthesis

This protein is involved in the pathway LPS lipid A biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway LPS lipid A biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei242Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processLipid A biosynthesisUniRule annotationSAAS annotation, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotationImported
ORF Names:BIT33_03705Imported, HMPREF0010_00355Imported
OrganismiAcinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81)Imported
Taxonomic identifieri575584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
Proteomesi
  • UP000232041 Componenti: Unassembled WGS sequence
  • UP000005740 Componenti: Unassembled WGS sequence

Interactioni

Subunit structurei

Homotrimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi575584.HMPREF0010_00355

Structurei

3D structure databases

SMRiD0C6H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 92LpxDInterPro annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili331 – 351Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105D7M Bacteria
COG1044 LUCA

Family and domain databases

CDDicd03352 LbH_LpxD, 1 hit
HAMAPiMF_00523 LpxD, 1 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR007691 LpxD
IPR011004 Trimer_LpxA-like_sf
IPR020573 UDP_GlcNAc_AcTrfase_non-rep
PANTHERiPTHR43378 PTHR43378, 1 hit
PfamiView protein in Pfam
PF00132 Hexapep, 3 hits
PF14602 Hexapep_2, 1 hit
PF04613 LpxD, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01853 lipid_A_lpxD, 1 hit

Sequencei

Sequence statusi: Complete.

D0C6H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVQQYRLDE LAHLVKGELI GEGSLQFSNL ASLENAEVNH LTFVNGEKHL
60 70 80 90 100
DQAKVSRAGA YIVTAALKEH LPEKDNFIIV DNPYLAFAIL THVFDKKISS
110 120 130 140 150
TGIESTAQIH PSAVISETAY IGHYVVIGEN CVVGDNTVIQ SHTKLDDNVE
160 170 180 190 200
VGKDCFIDSH VTITGGSKLR DRVRIHSSTV IGGEGFGFAP YQGKWHRIAQ
210 220 230 240 250
LGSVLIGNDV RIGSNCSIDR GALDNTILED GVIIDNLVQI AHNVHIGSNT
260 270 280 290 300
AIAAKCGIAG STKIGKNCIL AGACGVAGHL SIADNVTLTG MSMVTKNISE
310 320 330 340 350
AGTYSSGTGL FENNHWKKTI VRLRQLADVP LTQITKRLDH IQAQIESLES

TFNLRK
Length:356
Mass (Da):38,400
Last modified:November 24, 2009 - v1
Checksum:iA653D4C4FB2A3692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704572 Genomic DNA Translation: EEX04590.1
MJHA01000005 Genomic DNA Translation: PJZ11737.1
RefSeqiWP_000868103.1, NZ_MJHA01000005.1

Genome annotation databases

EnsemblBacteriaiEEX04590; EEX04590; HMPREF0010_00355
ENW76438; ENW76438; F911_01728
PATRICifig|575584.18.peg.1840

Similar proteinsi

Entry informationi

Entry nameiD0C6H5_ACIB2
AccessioniPrimary (citable) accession number: D0C6H5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: June 20, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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