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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

TbgDal_IX7350

Organism
Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (TbgDal_X3100)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (TbgDal_IX7350)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105NADPUniRule annotation1
Binding sitei105SubstrateUniRule annotation1
Active sitei186Proton acceptorUniRule annotation1
Active sitei193Proton donorUniRule annotation1
Binding sitei194SubstrateUniRule annotation1
Binding sitei263Substrate; via amide nitrogenUniRule annotation1
Binding sitei290SubstrateUniRule annotation1
Binding sitei454Substrate; shared with dimeric partnerUniRule annotation1
Binding sitei460Substrate; shared with dimeric partnerUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14NADPUniRule annotation6
Nucleotide bindingi32 – 34NADPUniRule annotation3
Nucleotide bindingi77 – 79NADPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGluconate utilizationUniRule annotation, Pentose shuntUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00410

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation)
Gene namesi
ORF Names:TbgDal_IX7350Imported
OrganismiTrypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)Imported
Taxonomic identifieri679716 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma
Proteomesi
  • UP000002316 Componenti: Chromosome 9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC9ZZ10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 4766PGDInterPro annotationAdd BLAST295

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 133Substrate bindingUniRule annotation3
Regioni189 – 190Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the 6-phosphogluconate dehydrogenase family.UniRule annotation

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006114 6PGDH_C
IPR006113 6PGDH_Gnd/GntZ
IPR006115 6PGDH_NADP-bd
IPR006184 6PGdom_BS
IPR036291 NAD(P)-bd_dom_sf
IPR006183 Pgluconate_DH
PfamiView protein in Pfam
PF00393 6PGD, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000109 6PGD, 1 hit
PRINTSiPR00076 6PGDHDRGNASE
SMARTiView protein in SMART
SM01350 6PGD, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00873 gnd, 1 hit
PROSITEiView protein in PROSITE
PS00461 6PGD, 1 hit

Sequencei

Sequence statusi: Complete.

C9ZZ10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMDVGVVGL GVMGANLALN IAEKGFKVAV FNRTYSKSEE FMKANASAPF
60 70 80 90 100
AGNLKAFETM EAFAASLKKP RKALILVQAG AATDSTIEQL KKVFEKGDIL
110 120 130 140 150
VDTGNAHFKD QGRRAQQLEA AGLRFLGMGI SGGEEGARKG PAFFPGGTLS
160 170 180 190 200
VWEEIRPIVE AAAAKADDGR PCVTMNGSGG AGSCVKMYHN SGEYAILQIW
210 220 230 240 250
GEVFDILRAM GLNNDEVAAV LEDWKSKNFL KSYMLDISIA AARAKDKDGS
260 270 280 290 300
YLTEHVMDRI GSKGTGLWSA QEALEIGVPA PSLNMAVVSR QFTMYKTERQ
310 320 330 340 350
ANASNAPGIT QSPGYTLKNK SPSGPEIKQL YDSVCIAIIS CYAQMFQCLR
360 370 380 390 400
EMDKVHNFGL NLPATIATFR AGCILQGYLL KPMTEAFEKN PNISNLMCAF
410 420 430 440 450
QTEIRAGLQN YRDMVALITS KLEVSIPVLS ASLNYVTAMF TPTLKYGQLV
460 470
SLQRDVFGRH GYERVDKDGR ESFQWPELQ
Length:479
Mass (Da):52,166
Last modified:November 24, 2009 - v1
Checksum:iF4C22E63A7A27824
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN554972 Genomic DNA Translation: CBH14659.1
RefSeqiXP_011776925.1, XM_011778623.1

Genome annotation databases

GeneIDi23860781

Similar proteinsi

Entry informationi

Entry nameiC9ZZ10_TRYB9
AccessioniPrimary (citable) accession number: C9ZZ10
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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