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Protein

Argininosuccinate synthase

Gene

argG

Organism
Cronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92CitrullineUniRule annotation1
Binding sitei97CitrullineUniRule annotation1
Binding sitei122ATP; via amide nitrogenUniRule annotation1
Binding sitei124AspartateUniRule annotation1
Binding sitei128AspartateUniRule annotation1
Binding sitei128CitrullineUniRule annotation1
Binding sitei129AspartateUniRule annotation1
Binding sitei132CitrullineUniRule annotation1
Binding sitei181CitrullineUniRule annotation1
Binding sitei190CitrullineUniRule annotation1
Binding sitei266CitrullineUniRule annotation1
Binding sitei278CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 20ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTUR693216:G1GIS-189-MONOMER
UniPathwayiUPA00068; UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotationImported
Ordered Locus Names:Ctu_01940Imported
OrganismiCronobacter turicensis (strain DSM 18703 / LMG 23827 / z3032)Imported
Taxonomic identifieri693216 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000002069 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliC9Y4Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000230093
KOiK01940
OMAiGVGRIDM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.1260.10, 2 hits
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

C9Y4Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNHGIKKVV LAYSGGLDTS AIIPWLKENY EGCDVVACVV DIGQDRDDLK
60 70 80 90 100
GVEQKALRSG ASECYVVDAR EEFIKDYVYP VLQTGALYEG SYLLGTSMAR
110 120 130 140 150
PLIAKALVDV AKKVGADALC HGATGKGNDQ VRFESAWAAL APHLKVIAPW
160 170 180 190 200
REWNLRSREA LLDYLKARDI PTTASLEKIY SRDENAWHIS TEGGVLESPW
210 220 230 240 250
NAPNQDCWVW TVDPKDAPDE AEQVTVTVEK GNVVAVNGEH LTPFGCLEVL
260 270 280 290 300
NKIGAKHGVG RIDIVENRLV GIKSRGCYET PGGTIMMAAL RGVEQLVLDR
310 320 330 340 350
DSFKWREQVG LEMSYVVYDG RWFAPLRQSL QAAAQSLAEQ VSGEVVLELY
360 370 380 390 400
KGQVTAIQKK STNSLYNEEF ATFGEDEVYD HSHAGGFIRL FSLSSRIRAL

NELKK
Length:405
Mass (Da):44,782
Last modified:November 24, 2009 - v1
Checksum:i2C334557C51D3FAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN543093 Genomic DNA Translation: CBA26977.1
RefSeqiWP_012814863.1, NC_013282.2

Genome annotation databases

EnsemblBacteriaiCBA26977; CBA26977; CTU_01940
KEGGictu:CTU_01940
PATRICifig|693216.3.peg.183

Similar proteinsi

Entry informationi

Entry nameiC9Y4Q9_CROTZ
AccessioniPrimary (citable) accession number: C9Y4Q9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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