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Protein

Ribonuclease HII

Gene

rnhB

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi10Divalent metal cationUniRule annotation1
Metal bindingi114Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMVUL579137:G1GGC-167-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:Metvu_0169Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi579137.Metvu_0169

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 217RNase_HIIInterPro annotationAdd BLAST212

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili120 – 140Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG04121 Archaea
COG0164 LUCA
HOGENOMiHOG000100289
KOiK03470
OMAiREECRFF
OrthoDBiPOG093Z0CAA

Family and domain databases

Gene3Di1.10.10.460, 1 hit
3.30.420.10, 1 hit
HAMAPiMF_00052_A RNase_HII_A, 1 hit
InterProiView protein in InterPro
IPR004649 RNase_H2_suA
IPR001352 RNase_HII/HIII
IPR024567 RNase_HII/HIII_dom
IPR020787 RNase_HII_arc
IPR023160 RNase_HII_hlx-loop-hlx_cap_dom
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10954 PTHR10954, 1 hit
PfamiView protein in Pfam
PF01351 RNase_HII, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00729 TIGR00729, 1 hit

Sequencei

Sequence statusi: Complete.

C9REN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLIIVGVDE AGRGPVLGPM VVCAFAIEKD REDLLRDLGV KDSKLLSKSK
60 70 80 90 100
RSQLKKQLER IGYVKKKILT ANEINTLMNK INLNEIEINA FSEVIMGLIN
110 120 130 140 150
DLNLKDEYLE IYVDACSTNA KKFENELKNR IKDIENQKNL KIKVIAEHKA
160 170 180 190 200
DLKYPIVSSA SIIAKADRDE IIEQYKKKYG EIGSGYPSDP KTIKFLEKYF
210 220 230
EEYGSLPNIA RVHWKTCKRI LDRSKQTTLK LDL
Length:233
Mass (Da):26,652
Last modified:November 24, 2009 - v1
Checksum:iBFA93ADC18BBEA10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX72036.1
RefSeqiWP_012819582.1, NC_013407.1

Genome annotation databases

EnsemblBacteriaiACX72036; ACX72036; Metvu_0169
GeneIDi8512497
KEGGimvu:Metvu_0169

Similar proteinsi

Entry informationi

Entry nameiC9REN4_METVM
AccessioniPrimary (citable) accession number: C9REN4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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