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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

Metvu_0116

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (Metvu_0116)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (Metvu_0116)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotationImported, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

BioCyciMVUL579137:G1GGC-114-MONOMER
UniPathwayiUPA00241; UER00353
UPA00241; UER00354

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
Ordered Locus Names:Metvu_0116Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi579137.Metvu_0116

Structurei

3D structure databases

ProteinModelPortaliC9REI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 181FlavoproteinInterPro annotationAdd BLAST164
Domaini189 – 369DFPInterPro annotationAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili283 – 303Sequence analysisAdd BLAST21
Coiled coili327 – 347Sequence analysisAdd BLAST21

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiarCOG01704 Archaea
COG0452 LUCA
HOGENOMiHOG000037525
KOiK13038
OMAiWEHPATQ
OrthoDBiPOG093Z0CF9

Family and domain databases

Gene3Di3.40.50.10300, 1 hit
3.40.50.1950, 1 hit
InterProiView protein in InterPro
IPR035929 CoaB-like_sf
IPR005252 CoaBC
IPR007085 DNA/pantothenate-metab_flavo_C
IPR036551 Flavin_trans-like
IPR003382 Flavoprotein
PfamiView protein in Pfam
PF04127 DFP, 1 hit
PF02441 Flavoprotein, 1 hit
SUPFAMiSSF102645 SSF102645, 1 hit
SSF52507 SSF52507, 1 hit
TIGRFAMsiTIGR00521 coaBC_dfp, 1 hit

Sequencei

Sequence statusi: Complete.

C9REI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPTKLLKGT KSKLLEGKKI LVAVTSSIAA IETPKLMREL IRHGAEVYCI
60 70 80 90 100
ITEETKKIIG KEALKFGCGN EVYEEITGDI EHILLYNECD CLLIYPATAN
110 120 130 140 150
IISKINLGIA DNIINTTALM FIGNKPIFIV PAMHENMFKA IKRHIDELKE
160 170 180 190 200
KDNIYIISPK FEEGKAKVAS IEDVVKVVIE KIGNNLKKEG NRVLILNGGT
210 220 230 240 250
IEFIDKVRVI SNLSSGKMGV ALAEAFCKEG FYVEVITAMG LEPPYYIKNH
260 270 280 290 300
KVLTAKEMLN KAIELAKDFD IIISSAAISD FTVERFEGKL SSEEELILKL
310 320 330 340 350
KRNPKVLEEL RRIYKDKIII GFKAEYNLDE KELINRAKER LNKYNLNMII
360 370 380 390 400
ANDLSEHYFG DDYIEVYIIT KNDIEKISGS KKYVAEKIVE KVKELVKCHV
Length:400
Mass (Da):45,300
Last modified:November 24, 2009 - v1
Checksum:i3897CC52BDAA3087
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX71984.1
RefSeqiWP_012819530.1, NC_013407.1

Genome annotation databases

EnsemblBacteriaiACX71984; ACX71984; Metvu_0116
GeneIDi8512442
KEGGimvu:Metvu_0116

Similar proteinsi

Entry informationi

Entry nameiC9REI2_METVM
AccessioniPrimary (citable) accession number: C9REI2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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