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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43NADUniRule annotation1
Binding sitei70NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei134NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi162Iron; shared with adjacent protomerUniRule annotation1
Metal bindingi177IronUniRule annotation1
Binding sitei180NAD; via carbonyl oxygenUniRule annotation1
Binding sitei226NAD; via amide nitrogenUniRule annotation1
Binding sitei236GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi62 – 63NADUniRule annotation2
Nucleotide bindingi160 – 162NAD; shared with adjacent protomerUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

BioCyciMVUL579137:G1GGC-1587-MONOMER
UniPathwayi
UPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
Ordered Locus Names:Metvu_1585Imported
OrganismiMethanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7) (Methanococcus vulcanius)Imported
Taxonomic identifieri579137 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000002063 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi579137.Metvu_1585

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

C9RDQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLKEIKLNA DETKTTKAIL KASFDMWMDI VEADVVIVGS GPSGLTCARY
60 70 80 90 100
LAKEGFKVVV LERHLAFGGG TWGGGMGFPY IAVEEPADEL LREIGVNLID
110 120 130 140 150
MGDGYYVADS VEVPAKLAVA AMNAGAKILT GIVVEDLILR EEGVAGVVIN
160 170 180 190 200
SYAIERAGLH IDPLTIRSKV VVDATGHEAS VVNTLVKKNK LEADVPGEKS
210 220 230 240 250
MWAEKGENAL LRNTREVYPN LFVCGMAANA SHGGYRMGAV FGGMYLSGKL
260
CAELIIEKLK RE
Length:262
Mass (Da):28,103
Last modified:November 24, 2009 - v1
Checksum:i0ECCEBCB310CFD92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX73438.1
RefSeqiWP_015733657.1, NC_013407.1

Genome annotation databases

EnsemblBacteriaiACX73438; ACX73438; Metvu_1585
GeneIDi8513942
KEGGimvu:Metvu_1585

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001787 Genomic DNA Translation: ACX73438.1
RefSeqiWP_015733657.1, NC_013407.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi579137.Metvu_1585

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX73438; ACX73438; Metvu_1585
GeneIDi8513942
KEGGimvu:Metvu_1585

Phylogenomic databases

eggNOGiarCOG00574 Archaea
COG1635 LUCA
HOGENOMiHOG000106048
KOiK22699
OMAiMWGGGMM
OrthoDBiPOG093Z09PU

Enzyme and pathway databases

UniPathwayi
UPA00060

BioCyciMVUL579137:G1GGC-1587-MONOMER

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9RDQ9_METVM
AccessioniPrimary (citable) accession number: C9RDQ9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 24, 2009
Last sequence update: November 24, 2009
Last modified: October 10, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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