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Entry version 47 (22 Apr 2020)
Sequence version 1 (24 Nov 2009)
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Protein

AM-toxin synthetase AMT1

Gene

AMT1

Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene clusters that mediate the biosynthesis of AM-toxins, host-selective toxins (HSTs) causing Alternaria blotch on apple, a worldwide distributed disease (PubMed:10875335, PubMed:17990954, PubMed:11570518). AM-toxins are cyclic depsipeptides containing the 3 residues 2-hydroxy-isovaleric acid (2-HIV), dehydroalanine, L-alanine which are common for all 3 AM-toxins I to III. The fourth precursor is L-alpha-amino-methoxyphenyl-valeric acid (L-Amv) for AM-toxin I, L-alpha-amino-phenyl-valeric acid (L-Apv) for AM-toxin II, and L-alpha-amino-hydroxyphenyl-valeric acid (L-Ahv) for AM-toxin III (Probable). AM-toxins have two target sites for affecting susceptible apple cells; they cause invagination of the plasma membrane and electrolyte loss, and chloroplast disorganization (PubMed:22846083). The non-ribosomal peptide synthetase AMT1 contains 4 catalytic modules and is responsible for activation of each residue in AM-toxin (PubMed:10875335). The aldo-keto reductase AMT2 catalyzes the conversion of 2-keto-isovaleric acid (2-KIV) to 2-hydroxy-isovaleric acid (2-HIV), one of the precursor residues incorporated by AMT1 during AM-toxin biosynthesis, by reduction of its ketone to an alcohol (PubMed:15066029). The cytochrome P450 monooxygenase AMT3 and the thioesterase AMT4 are also important for AM-toxin production, but their exact function within the AM-toxin biosynthesis are not known yet (PubMed:17990954). Up to 21 proteins (including AMT1 to AMT4) are predicted to be involved in AM-toxin biosynthesis since their expression ishighly up-regulated in AM-toxin-producing cultures (PubMed:17990954).1 Publication1 Publication4 Publications

Miscellaneous

Gene clusters encoding host-selective toxins (HSTs) are localized on conditionally dispensable chromosomes (CDCs), also called supernumerary chromosomes, where they are present in multiple copies (PubMed:17990954, PubMed:11570518). The CDCs are not essential for saprophytic growth but controls host-selective pathogenicity (PubMed:17990954, PubMed:11570518).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AM-toxin synthetase AMT11 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Cyclic peptide synthetase AMT1 Publication
Nonribosomal peptide synthetase AMT11 Publication
Short name:
NRPS AMT1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMT11 Publication
Synonyms:AMT1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5599 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria sect. AlternariaAlternaria alternata complex

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduces AM-toxin production to undetectable levels.1 Publication

Miscellaneous databases

Pathogen-Host Interaction database

More...
PHI-basei
PHI:160

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004448121 – 4363AM-toxin synthetase AMT1Add BLAST4363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei847O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1922O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3014O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3767O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is up-regulated more than 10 fold in toxin producing cultures.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
C9K7B5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini810 – 887Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini1884 – 1961Carrier 2PROSITE-ProRule annotationAdd BLAST78
Domaini2977 – 3053Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini3730 – 3806Carrier 4PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni278 – 670Adenylation 1Sequence analysisAdd BLAST393
Regioni926 – 1340Condensation 1Sequence analysisAdd BLAST415
Regioni1368 – 1765Adenylation 2Sequence analysisAdd BLAST398
Regioni1999 – 2410Condensation 2Sequence analysisAdd BLAST412
Regioni2448 – 2853Adenylation 3Sequence analysisAdd BLAST406
Regioni3098 – 3503Condensation 3Sequence analysisAdd BLAST406
Regioni3850 – 4204Condensation 4Sequence analysisAdd BLAST355

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase (By similarity). AMT1 has the following architecture: A-T-C-A-T-C-A-T-C-T-C (Probable).By similarity1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 4 hits
PF00550, PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 4 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

C9K7B5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELNDDPTGK IISGVNDISL PSLSAKQVAQ SLSEQLSTSA LPAIQSFSFP
60 70 80 90 100
PLPNGLSETF HDKKMDLSYA FPRKLMSALE VSSMFCAAWA IAVDRYTTND
110 120 130 140 150
DVVFGAFLQD IPNPGLVPLR LKTRSETDVG GLLHYVISEI TQSCNYPYLG
160 170 180 190 200
KEKSSELSTE RQDSHEVGAM LVFGKSGAGE SNVLYEKPIT CALTITCTLA
210 220 230 240 250
GDQLHIGASY DSRVIEAPML TRVLRQFGYL ATQLADANPT RRLTDIAQEL
260 270 280 290 300
NRQDLEDIWK TNMEITTESG ALIQEIFAGQ AKQRPHAIAV EAWDGVLSYG
310 320 330 340 350
QLESLSTGLA HALLQLGIKD HSLIPFCLKN SKWAVVAMLG ILKANCTFVP
360 370 380 390 400
IDSSSPWDRR NRILELTHAE VIITSSFMSD DNLWNTSVLC LTEETVSGFP
410 420 430 440 450
VLSNLPGRIS GPGSAAYVLF TSGSTGDPKG VVVAHSAICN SLHAIGSKIG
460 470 480 490 500
LDETSRTLQF TSLAFDISIF EILGTLIFGG TICVPSEDDR LTRLPEYIVS
510 520 530 540 550
AQVNTASLTP SVARLYDAAM VPCLNTLILG GEAMTRADIK NWCRLPNLFN
560 570 580 590 600
GFGPTETAIG CAMHRVHAEQ KQHSLIGRLA GIPVWVVDPS DHEVLVPFGA
610 620 630 640 650
VGELVVEGTT LALGYLDDDI KTQAAFIQDP PWLLRGCGVE LPGRRGRIYK
660 670 680 690 700
TGDLVQYNEE GSLLYVGRKD SDTQVKIRGN RVDLGEIESH LHECLPSRSE
710 720 730 740 750
VVVDVVLPSD APTSSDHILA VFLRYEGVNT LQDSTERTIP TKLIQVPEGI
760 770 780 790 800
QKHLYSKLPA YMVPTVYFSV AVIPKMISGK TDRKRLRGMA SLFSMQELAA
810 820 830 840 850
NSSHQTVKRA PDSVIARQLQ GIWAQVLHVD PLAIGMDDSF FALGGDSIAA
860 870 880 890 900
IRLVREARQT FSIGLTVADI FSFPSLGALA AIAKVIPLID PGPSPAFTSL
910 920 930 940 950
RGVSSITDLL KDVAESCGLK QPSLIEDVYA CTPLQEGLLA LSSKHSGTYT
960 970 980 990 1000
VQRVLELAPD VDIARFQAAW ETTARCTPIM RTRIVQHVEL GLLQAVVDED
1010 1020 1030 1040 1050
IEWKTLPSEQ LDSFLLADQK TSMALGQPLM RYALTQGPYS GTHGSRHLVW
1060 1070 1080 1090 1100
TVHHALYDGW SLPLLLERVR QAYYGEQPQL SEFAPFIRWC EQDVDEDSAA
1110 1120 1130 1140 1150
RHWQTYLEEA DESALFPPLP PSITEPIEDQ QAENRWALPE HGTTAVTRSI
1160 1170 1180 1190 1200
VLRAAWAIVA SRYTSSNDVL FGTTVSGRGA PVPGIEEMVG PTVATVPTRC
1210 1220 1230 1240 1250
KIDDNKSASS FLLEVQQAAV EAIPFEQTGL KRISEIDTRL RRVREIQTFL
1260 1270 1280 1290 1300
VVQPAEYGEA AFEGLGKWVN GPGYYRLDVS ALTLECVLTE SGVRCVAYFD
1310 1320 1330 1340 1350
SHVIQAATVT RALAQFAHVS QQLCTASPNT TLGQIDVLTS SDLRDIWNWN
1360 1370 1380 1390 1400
GPLLQLAEEP LPHVDIGKQA RTRPGAIAVH SWDAQLTYQE LDKYSSLLAK
1410 1420 1430 1440 1450
QLLDADVKGG DIVPLYFEPS AWVVVAMLAV LKSGAAFTPI DTSQPEQRRN
1460 1470 1480 1490 1500
RIVSQLQPSI GLVSARHATT VFGPGWATLE VSRRALSSMP EGPLGQVDAS
1510 1520 1530 1540 1550
SIAWVIFTSG STGLPKGAML QHSAVHTSHR ALGATFGLCA NTRMLQFSSF
1560 1570 1580 1590 1600
AFDACVLEIV ATLMHGGCVC IPSELQQRSL SELPSVCAAM EVNTMVLTPT
1610 1620 1630 1640 1650
VARLFGPSDF PDLTTLVLTG EPLVQSDVTK WSSIAYVANG YGPAECSNIC
1660 1670 1680 1690 1700
TVHRIAPDDT DPNRIGSLRG VPNWVVHSRN HHQLTPIGGV GELLIEGATV
1710 1720 1730 1740 1750
GHGYLNDAEK TAAAFVTDPA WLTEISHALP CFERHGRLYK TGDIVKLHED
1760 1770 1780 1790 1800
GSLSYLGRKD TQIKIHGQRI ELGEIEHHVL HCTKAVEVTV DAVYVPGEEK
1810 1820 1830 1840 1850
NKSLVAFVRP SNGTSTPQFY DNPDAIINEL ANSLPAYMIP TMYIQVPSIP
1860 1870 1880 1890 1900
RTASGKTDRK QLREMGTAMA SSHAARHWKH QNRPPVTDME KHVQKLWARV
1910 1920 1930 1940 1950
LTLENAGEIS LDDSFIRLGG DSIAAMKLVS LAAKAGLGLT VAQIFRHTKL
1960 1970 1980 1990 2000
EDQARHVTLL TQGGPAPIAQ FSLLPDSPDV KALQADIARA YAIEASSIED
2010 2020 2030 2040 2050
VYPCTPLQEG LLSLSSKPSE YNTYTLQHVF ELPPTVDIQQ LRSAWEETIR
2060 2070 2080 2090 2100
TTDILRTRIV LHPRYGLVQV VVKEEIQWHE PANADVYIET DKQVQMVLGS
2110 2120 2130 2140 2150
SLVRYAISPD TGSASRKFIW TIHHALADGW TLDLILRKVK LAYSTLHTVS
2160 2170 2180 2190 2200
PVSEFRSFVK YITTRNTDEM VEYWKSTLGG YHSTTFPALP SSVRYAIEDS
2210 2220 2230 2240 2250
EVGQKHELPR NITLSAHPLS TLLRAAWAIV QSNYSNTSDV VFGEVFSGRS
2260 2270 2280 2290 2300
ASVPFIEAIV GPTMATLPVR VKIDDSELAR EMLDRLLTTT TQMIPHEQLG
2310 2320 2330 2340 2350
LQRISQINTD CQAACSFQTL LVIQPPASTH NGQEEPSLSF SGSPDYRLAT
2360 2370 2380 2390 2400
YALGIECTPA SDGYSFSCRA RFDSRVLSAQ VAERMMAQLG HVVSQLVAVT
2410 2420 2430 2440 2450
ASPSSSTLVS DIVLNTPQDL EKLWAWNEAV LELGEEQKHS MLLHQVFRKK
2460 2470 2480 2490 2500
ALAAPQATAI SSWDGECSYA QLEKLSDALA AMLTDLGIGI GLDQQLVPLC
2510 2520 2530 2540 2550
FERSMWVVVA MMAVLKTGAG IVPLDPAHPP SRHERILAKV GIGGCILVSP
2560 2570 2580 2590 2600
QYAQRQFGEG WTTMVVSEAS AAAVPSIHAF DPPTVTHLAV CWILFTSGST
2610 2620 2630 2640 2650
GEPKGIYLEH GAICASYKLL GKTLGIDKET RMLHFSAYAF DIATFEIIGT
2660 2670 2680 2690 2700
LMSGGCICIP SDAERLERLP QFCTTFAVNT AILTPSVARL YTPNDIPTLR
2710 2720 2730 2740 2750
SLCLAGEAPN KQDISTWQHR IPFLFNCYGP AEAACLAATN RIGPNDADRS
2760 2770 2780 2790 2800
ATRIGRLRGV PLWITAPGNC RKLAPIGAVG ELLIEGSTLA RGYLDPTQTD
2810 2820 2830 2840 2850
AAFIEDPEWL LQGPAGERSG RRGRLYRTGD LARYDEDGGV VYEGRKDNQV
2860 2870 2880 2890 2900
KIRGQRTELG EIEYHLSQCF PTAAEVVVEV ATSERDLASV TLVAFVKSRE
2910 2920 2930 2940 2950
TRDSSEKVPA GIFALPSKLE HEINRRLPLY MIPAVFVSVP EIPKTATDKT
2960 2970 2980 2990 3000
DRQKLRELAS VYATRAVDAP HHQPQRLPST VMEETLRDLW LKVIPVRQTA
3010 3020 3030 3040 3050
IGLDSNFFRL GGDSIAALKL VGQAQQAGIE LSSKDIFLNP KLVDLAACCT
3060 3070 3080 3090 3100
DRRCVKEGSR MVAKHATISR FSLLPINASI SSIVDEVANA CGIPPRLVED
3110 3120 3130 3140 3150
VYPCTPMQEG LMSLSSRNPG TYVSQIAIEL APDVLVDLFK LAWQQTVSTM
3160 3170 3180 3190 3200
PILRSRIIQH PKLGFLQAVL KEDVTWNNST DLDEYLETDS STPMGFGSEL
3210 3220 3230 3240 3250
SRHALVWDNS GKHIRFVWTV HHSIYDHVTL RLILDDVYDN YKGNERKDFQ
3260 3270 3280 3290 3300
PYTSFVRSVI SMKSSESEEF WRNACKDEGS SIFPQRSLSI RESCEDTTVE
3310 3320 3330 3340 3350
QSYQLCTTAT GVTMANVLHA AWAVVSSWHV GNQSIVFGTV LSGRTAPVLG
3360 3370 3380 3390 3400
IENIAGPTIA TAPFPVIIDP SETISNFLQR IQGQMAAVIP HAQLGLQRIS
3410 3420 3430 3440 3450
RLSSACELAC NFQTLFAVQE GRAMVGNSLG KLLDVNTFSM RTYALTLDCF
3460 3470 3480 3490 3500
LDTEGFHVKA SFDSRVVDQW RMESILRQFG AVAQQLATKA EGGELVSSIE
3510 3520 3530 3540 3550
TLNEQGWELL RRWNSHRTHK QWAVFPEDCE KPSPIGAIGE LLIEGPDFPS
3560 3570 3580 3590 3600
KYLEDPGARK VRSPRWMDRN GHKTVLLTGI LVAFDQNGNS IHIGQKRTTI
3610 3620 3630 3640 3650
SFKGQRIDVS QIERHITSFL AGTEAVVEAI AIPSAENSQS VLAVFLHRPE
3660 3670 3680 3690 3700
LADRGDNKSR PAICWSKDYG DIEKNLSVVF PDMVPTLYID MEAMPRTSHG
3710 3720 3730 3740 3750
DIDRSQLQTL GSLFPAEKVA ILRASRQKRP AVTAMQLAIR GLWASLLGAK
3760 3770 3780 3790 3800
EDTFHLDDDF FKSGGDSIGV IKLVGEARKR NIALAAADIF QYPKLESLAV
3810 3820 3830 3840 3850
RATENTLSQA EELEEPFSLI TSYVDDADRI EDFLSSNILS RIPYAREALQ
3860 3870 3880 3890 3900
DVLPCTSMQK QLFHAQGQIY RFVLDFGDAQ IDAHRLEHAV HGLIDRHAIL
3910 3920 3930 3940 3950
RTLFVPYQTD LLQVVVSPGK LKGRFVAETL GDGDEIEAAV ERVVSADKAD
3960 3970 3980 3990 4000
TNITGCPMPQ FIFLSKRSKT EGFQSKLIIA RFSHMQFDGY SVPFVIRDLA
4010 4020 4030 4040 4050
TLYAATTSNT NTLDADEERT LIVASETLPP APQFSSYIYA HYSTSSLERR
4060 4070 4080 4090 4100
KYWMRLLRAS YMTPITVKCD TPERIYNHTR YENRTVELEA WYRIASSGQS
4110 4120 4130 4140 4150
SPDDILTMAW ALTLSIASEE SDIVFGRTVA GRRALFIPHG GADDIMGPCV
4160 4170 4180 4190 4200
NTIPVRVQLP STTEQEEVDK SMTLRDLLAE IHKQTKETLP FESTGLDEIV
4210 4220 4230 4240 4250
EHYAPSIWKK KPRRWTSTVV WQDFAGMQAV QHTVHRRSGN HEPNGEEKYE
4260 4270 4280 4290 4300
KVGQEDGSVA LGYMDPFAAS SNVAFADLTC RVTCEIPLFD PADVAVIGRL
4310 4320 4330 4340 4350
VDGSPCFALG FAPERVPEPT IKRLADTLMA VVLCLAEHPE TSVKHLLRAQ
4360
RENWRSIREL PNV
Length:4,363
Mass (Da):479,692
Last modified:November 24, 2009 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B1DE2FFE532F0C0
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF01762 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2986L → I in BAI44801 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF184074 Genomic DNA Translation: AAF01762.1 Sequence problems.
AB525198 Genomic DNA Translation: BAI44739.1
AB525200 Genomic DNA Translation: BAI44801.1
AB525199 Genomic DNA Translation: BAI44759.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF184074 Genomic DNA Translation: AAF01762.1 Sequence problems.
AB525198 Genomic DNA Translation: BAI44739.1
AB525200 Genomic DNA Translation: BAI44801.1
AB525199 Genomic DNA Translation: BAI44759.1

3D structure databases

SMRiC9K7B5
ModBaseiSearch...

Miscellaneous databases

PHI-baseiPHI:160

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 4 hits
PF00550, PP-binding, 4 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 4 hits
SUPFAMiSSF47336, SSF47336, 4 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 4 hits
PS00012, PHOSPHOPANTETHEINE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMT1_ALTAL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: C9K7B5
Secondary accession number(s): C9K7D5, C9K7H7, Q9UVN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 18, 2018
Last sequence update: November 24, 2009
Last modified: April 22, 2020
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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