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Protein
Submitted name:

Glia-derived nexin

Gene

SERPINE2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Glia-derived nexinImported
Gene namesi
Name:SERPINE2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135919.12
HGNCiHGNC:8951 SERPINE2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135919

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500841293520 – 86Sequence analysisAdd BLAST67

Proteomic databases

PeptideAtlasiC9K031
PRIDEiC9K031

Expressioni

Gene expression databases

BgeeiENSG00000135919 Expressed in 232 organ(s), highest expression level in decidua
ExpressionAtlasiC9K031 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9K031
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 83SERPINInterPro annotationAdd BLAST51

Sequence similaritiesi

Belongs to the serpin family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

C9K031-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNWHLPLFLL ASVTLPSICS HFNPLSLEEL GSNTGIQVFN QIVKSRPHDN
60 70 80
IVISPHGIAS VLGMLQLGAD GRTKKQLAMV MRYGVN
Length:86
Mass (Da):9,424
Last modified:October 5, 2016 - v8
Checksum:iB1651EDCABBDEF8F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P07093GDN_HUMAN
Glia-derived nexin
SERPINE2 PI7, PN1
398Annotation score:
C9JN98C9JN98_HUMAN
Glia-derived nexin
SERPINE2
275Annotation score:
C9JRK5C9JRK5_HUMAN
Glia-derived nexin
SERPINE2
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei86Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073641 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000454956; ENSP00000399655; ENSG00000135919
UCSCiuc061tcv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073641 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliC9K031
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiC9K031
PRIDEiC9K031

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000454956; ENSP00000399655; ENSG00000135919
UCSCiuc061tcv.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000135919.12
HGNCiHGNC:8951 SERPINE2
OpenTargetsiENSG00000135919
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00930000150820

Miscellaneous databases

ChiTaRSiSERPINE2 human

Gene expression databases

BgeeiENSG00000135919 Expressed in 232 organ(s), highest expression level in decidua
ExpressionAtlasiC9K031 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiC9K031_HUMAN
AccessioniPrimary (citable) accession number: C9K031
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 72 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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