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Protein

Carboxylic ester hydrolase

Gene

ACHE

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation

Protein family/group databases

ESTHERihuman-ACHE AChE

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylic ester hydrolaseUniRule annotation (EC:3.1.1.-UniRule annotation)
Gene namesi
Name:ACHEImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000087085.13
HGNCiHGNC:108 ACHE

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000087085

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33UniRule annotationAdd BLAST33
ChainiPRO_500819225834 – 434Carboxylic ester hydrolaseUniRule annotationAdd BLAST401

Proteomic databases

PeptideAtlasiC9JZL6
PRIDEiC9JZL6

Expressioni

Gene expression databases

BgeeiENSG00000087085 Expressed in 145 organ(s), highest expression level in hypothalamus
ExpressionAtlasiC9JZL6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliC9JZL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 387COesteraseInterPro annotationAdd BLAST349

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalUniRule annotation

Phylogenomic databases

eggNOGiKOG4389 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR000997 Cholinesterase
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PRINTSiPR00878 CHOLNESTRASE
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

C9JZL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPPQCLLHT PSLASPLLLL LLWLLGGGVG AEGREDAELL VTVRGGRLRG
60 70 80 90 100
IRLKTPGGPV SAFLGIPFAE PPMGPRRFLP PEPKQPWSGV VDATTFQSVC
110 120 130 140 150
YQYVDTLYPG FEGTEMWNPN RELSEDCLYL NVWTPYPRPT SPTPVLVWIY
160 170 180 190 200
GGGFYSGASS LDVYDGRFLV QAERTVLVSM NYRVGAFGFL ALPGSREAPG
210 220 230 240 250
NVGLLDQRLA LQWVQENVAA FGGDPTSVTL FGESAGAASV GMHLLSPPSR
260 270 280 290 300
GLFHRAVLQS GAPNGPWATV GMGEARRRAT QLAHLVGCPP GGTGGNDTEL
310 320 330 340 350
VACLRTRPAQ VLVNHEWHVL PQESVFRFSF VPVVDGDFLS DTPEALINAG
360 370 380 390 400
DFHGLQVLVG VVKDEGSYFL VYGAPGFSKD NESLISRAEF LAGTRSTRRS
410 420 430
ASGRPSSTAG APTWCTGRTS STTTASRIAA QTCD
Length:434
Mass (Da):46,461
Last modified:October 5, 2016 - v8
Checksum:i2D37DE0BF787135D
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P22303ACES_HUMAN
Acetylcholinesterase
ACHE
614Annotation score:
F8WD68F8WD68_HUMAN
Carboxylic ester hydrolase
ACHE
403Annotation score:
F8WAR7F8WAR7_HUMAN
Carboxylic ester hydrolase
ACHE
359Annotation score:
C9J2S3C9J2S3_HUMAN
Carboxylic ester hydrolase
ACHE
397Annotation score:
C9JD78C9JD78_HUMAN
Acetylcholinesterase
ACHE
158Annotation score:
F8WD34F8WD34_HUMAN
Acetylcholinesterase
ACHE
55Annotation score:
Q6TQD3Q6TQD3_HUMAN
Acetylcholinesterase
ACHE
94Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei434Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011895 Genomic DNA No translation available.
KF510962 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000430554; ENSP00000399725; ENSG00000087085
UCSCiuc064gjg.1 human

Similar proteinsi

Entry informationi

Entry nameiC9JZL6_HUMAN
AccessioniPrimary (citable) accession number: C9JZL6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 3, 2009
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 61 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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